Improved understanding of NSCLC immunotherapy response mechanisms from single-cell analysis

por Bienkowska, Kamila Justyna, Hanley, Christopher Jon
Publicado 2023

T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting

por Hanley, Christopher J., Thomas, Gareth J.
Publicado 2020

Targeting cancer associated fibroblasts to enhance immunotherapy: emerging strategies and future perspectives

por Hanley, Christopher J., Thomas, Gareth J.
Publicado 2021

Bladder teratoma in a maned wolf (Chrysocyon brachyurus)

por Fox, Lana, Hanley, Christopher S, Padilla, Luis R, Duncan, Mary
Publicado 2019

Cancer-Associated Fibroblasts in Oral Cancer: A Current Perspective on Function and Potential for Therapeutic Targeting

por Bienkowska, Kamila J., Hanley, Christopher J., Thomas, Gareth J.
Publicado 2021

An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing

por Waise, Sara, Parker, Rachel, Rose-Zerilli, Matthew J. J., Layfield, David M., Wood, Oliver, West, Jonathan, Ottensmeier, Christian H., Thomas, Gareth J., Hanley, Christopher J.
Publicado 2019

CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer

por Fleming, Jason C., Woo, Jeongmin, Moutasim, Karwan, Hanley, Christopher J., Frampton, Steven J., Wood, Oliver, Ward, Matthew, Woelk, Christopher H., Ottensmeier, Christian H., Hafizi, Sassan, Kim, Dae, Thomas, Gareth J.
Publicado 2020

Pro‐migratory and TGF‐β‐activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8‐dependent GTPase switch

por Tod, Jo, Hanley, Christopher J, Morgan, Mark R, Rucka, Marta, Mellows, Toby, Lopez, Maria‐Antoinette, Kiely, Philip, Moutasim, Karwan A, Frampton, Steven J, Sabnis, Durgagauri, Fine, David R, Johnson, Colin, Marshall, John F, Scita, Giorgio, Jenei, Veronika, Thomas, Gareth J
Publicado 2017

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

por Hanley, Christopher J., Waise, Sara, Ellis, Matthew J., Lopez, Maria A., Pun, Wai Y., Taylor, Julian, Parker, Rachel, Kimbley, Lucy M., Chee, Serena J., Shaw, Emily C., West, Jonathan, Alzetani, Aiman, Woo, Edwin, Ottensmeier, Christian H., Rose-Zerilli, Matthew J. J., Thomas, Gareth J.
Publicado 2023

A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers

por Hanley, Christopher J., Noble, Fergus, Ward, Matthew, Bullock, Marc, Drifka, Cole, Mellone, Massimiliano, Manousopoulou, Antigoni, Johnston, Harvey E., Hayden, Annette, Thirdborough, Steve, Liu, Yuming, Smith, David M., Mellows, Toby, Kao, W. John, Garbis, Spiros D., Mirnezami, Alex, Underwood, Tim J., Eliceiri, Kevin W., Thomas, Gareth J.
Publicado 2015

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

por Hanley, Christopher J, Mellone, Massimiliano, Ford, Kirsty, Thirdborough, Steve M, Mellows, Toby, Frampton, Steven J, Smith, David M, Harden, Elena, Szyndralewiez, Cedric, Bullock, Marc, Noble, Fergus, Moutasim, Karwan A, King, Emma V, Vijayanand, Pandurangan, Mirnezami, Alex H, Underwood, Timothy J, Ottensmeier, Christian H, Thomas, Gareth J
Publicado 2017

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

por Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco, Carroll, Thomas, Dharmalingam, Gopuraja, Wee, Keng Boon, Mellone, Marco, Pombo, Joaquim, Heide, Danijela, Guccione, Ernesto, Arribas, Joaquín, Barbosa-Morais, Nuno L., Heikenwalder, Mathias, Thomas, Gareth J., Zender, Lars, Gil, Jesús
Publicado 2018

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

por Clarke, James, Panwar, Bharat, Madrigal, Ariel, Singh, Divya, Gujar, Ravindra, Wood, Oliver, Chee, Serena J., Eschweiler, Simon, King, Emma V., Awad, Amiera S., Hanley, Christopher J., McCann, Katy J., Bhattacharyya, Sourya, Woo, Edwin, Alzetani, Aiman, Seumois, Grégory, Thomas, Gareth J., Ganesan, Anusha-Preethi, Friedmann, Peter S., Sanchez-Elsner, Tilman, Ay, Ferhat, Ottensmeier, Christian H., Vijayanand, Pandurangan
Publicado 2019

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

por Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J, Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A., Withers, Dominic, Zender, Lars, Thomas, Gareth J., Gil, Jesús
Publicado 2015

ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

por Mellone, Massimiliano, Piotrowska, Klaudia, Venturi, Giulia, James, Lija, Bzura, Aleksandra, Lopez, Maria A., James, Sonya, Wang, Chuan, Ellis, Matthew J., Hanley, Christopher J., Buckingham, Josephine F., Cox, Kerry L., Hughes, Gareth, Valge-Archer, Viia, King, Emma V., Beers, Stephen A., Jaquet, Vincent, Jones, George D.D., Savelyeva, Natalia, Sayan, Emre, Parsons, Jason L., Durant, Stephen, Thomas, Gareth J.
Publicado 2022

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

por Mellone, Massimiliano, Hanley, Christopher J., Thirdborough, Steve, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steve, Jenei, Veronika, Moutasim, Karwan A., Kabir, Tasnuva D., Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W., Prime, Stephen S., Underwood, Timothy J., Vijayanand, Pandurangan, Eliceiri, Kevin W., Woelk, Christopher, King, Emma V., Gil, Jesus, Ottensmeier, Christian H., Thomas, Gareth J.
Publicado 2016