Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens

por Hegde, Mudra, Strand, Christine, Hanna, Ruth E., Doench, John G.
Publicado 2018

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

por Whicker, Margaret E., Lin, Z. Ping, Hanna, Ruth, Sartorelli, Alan C., Ratner, Elena S.
Publicado 2016

Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to...

por Roberts, Cai M., Rojas-Alexandre, Mehida, Hanna, Ruth E., Lin, Z. Ping, Ratner, Elena S.
Publicado 2023

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

por Chylinski, Krzysztof, Hubmann, Maria, Hanna, Ruth E., Yanchus, Connor, Michlits, Georg, Uijttewaal, Esther C. H., Doench, John, Schramek, Daniel, Elling, Ulrich
Publicado 2019

Genetic screens in isogenic mammalian cell lines without single cell cloning

por DeWeirdt, Peter C., Sangree, Annabel K., Hanna, Ruth E., Sanson, Kendall R., Hegde, Mudra, Strand, Christine, Persky, Nicole S., Doench, John G.
Publicado 2020

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

por Sangree, Annabel K., Griffith, Audrey L., Szegletes, Zsofia M., Roy, Priyanka, DeWeirdt, Peter C., Hegde, Mudra, McGee, Abby V., Hanna, Ruth E., Doench, John G.
Publicado 2022

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

por Sanson, Kendall R., Hanna, Ruth E., Hegde, Mudra, Donovan, Katherine F., Strand, Christine, Sullender, Meagan E., Vaimberg, Emma W., Goodale, Amy, Root, David E., Piccioni, Federica, Doench, John G.
Publicado 2018

Optimization of AsCas12a for combinatorial genetic screens in human cells

por DeWeirdt, Peter C, Sanson, Kendall R, Sangree, Annabel K, Hegde, Mudra, Hanna, Ruth E, Feeley, Marissa N, Griffith, Audrey L, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Publicado 2020

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

por Strine, Madison S., Cai, Wesley L., Wei, Jin, Alfajaro, Mia Madel, Filler, Renata B., Biering, Scott B., Sarnik, Sylvia, Chow, Ryan D., Patil, Ajinkya, Cervantes, Kasey S., Collings, Clayton K., DeWeirdt, Peter C., Hanna, Ruth E., Schofield, Kevin, Hulme, Christopher, Konermann, Silvana, Doench, John G., Hsu, Patrick D., Kadoch, Cigall, Yan, Qin, Wilen, Craig B.
Publicado 2023

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection

por Wei, Jin, Patil, Ajinkya, Collings, Clayton K., Alfajaro, Mia Madel, Liang, Yu, Cai, Wesley L., Strine, Madison S., Filler, Renata B., DeWeirdt, Peter C., Hanna, Ruth E., Menasche, Bridget L., Ökten, Arya, Peña-Hernández, Mario A., Klein, Jon, McNamara, Andrew, Rosales, Romel, McGovern, Briana L., Luis Rodriguez, M., García-Sastre, Adolfo, White, Kris M., Qin, Yiren, Doench, John G., Yan, Qin, Iwasaki, Akiko, Zwaka, Thomas P., Qi, Jun, Kadoch, Cigall, Wilen, Craig B.
Publicado 2023

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

por Wei, Jin, Alfajaro, Mia Madel, Hanna, Ruth E., DeWeirdt, Peter C., Strine, Madison S., Lu-Culligan, William J., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Gasque, Victor, de Miguel, Fernando, Chen, Huacui, Oguntuyo, Kasopefoluwa, Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett, Politi, Katerina, van Dijk, David, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Publicado 2020

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

por Wei, Jin, Alfajaro, Mia Madel, DeWeirdt, Peter C., Hanna, Ruth E., Lu-Culligan, William J., Cai, Wesley L., Strine, Madison S., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Ravindra, Neal G., Gasque, Victor, de Miguel, Fernando J., Patil, Ajinkya, Chen, Huacui, Oguntuyo, Kasopefoluwa Y., Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett D., Politi, Katerina, van Dijk, David, Kadoch, Cigall, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Publicado 2021