Too much or too little: Harnessing senescence to control oncogene-driven cancer

por Hannan, Katherine M., Pearson, Richard B.
Publicado 2012

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

por Ferreira, Rita, Schneekloth, John S., Panov, Konstantin I., Hannan, Katherine M., Hannan, Ross D.
Publicado 2020

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

por Lee, Rachel S., House, Colin M., Cristiano, Briony E., Hannan, Ross D., Pearson, Richard B., Hannan, Katherine M.
Publicado 2011

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

por Yan, Shunfei, Frank, Daniel, Son, Jinbae, Hannan, Katherine M., Hannan, Ross D., Chan, Keefe T., Pearson, Richard B., Sanij, Elaine
Publicado 2017

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

por Kerry, Louise E., Pegg, Elaine E., Cameron, Donald P., Budzak, James, Poortinga, Gretchen, Hannan, Katherine M., Hannan, Ross D., Rudenko, Gloria
Publicado 2017

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

por Son, Jinbae, Hannan, Katherine M., Poortinga, Gretchen, Hein, Nadine, Cameron, Donald P., Ganley, Austen R. D., Sheppard, Karen E., Pearson, Richard B., Hannan, Ross D., Sanij, Elaine
Publicado 2020

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

por Kang, Jian, Kusnadi, Eric P., Ogden, Allison J., Hicks, Rodney J., Bammert, Lukas, Kutay, Ulrike, Hung, Sandy, Sanij, Elaine, Hannan, Ross D., Hannan, Katherine M., Pearson, Richard B.
Publicado 2016

The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma

por Kang, Chang-Won, Hannan, Katherine M., Blackburn, Anneke C., Loh, Amos H. P., Hong, Kuick Chik, Yuan, Goh Jian, Hein, Nadine, Drygin, Denis, Hannan, Ross D., Coupland, Lucy A.
Publicado 2022

Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies

por Kang, Chang-Won, Blackburn, Anneke C., Loh, Amos Hong Pheng, Hong, Kuick Chick, Goh, Jian Yuan, Hein, Nadine, Drygin, Denis, Parish, Chris R., Hannan, Ross D., Hannan, Katherine M., Coupland, Lucy A.
Publicado 2023

A functional genetic screen defines the AKT-induced senescence signaling network

por Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.
Publicado 2019

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-gra...

por Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B., Chan, Keefe T.
Publicado 2020

UBF levels determine the number of active ribosomal RNA genes in mammals

por Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Quin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
Publicado 2008

Cell death and barrier disruption by clinically used iodine concentrations

por Steins, Anne, Carroll, Christina, Choong, Fui Jiun, George, Amee J, He, Jin-Shu, Parsons, Kate M, Feng, Shouya, Man, Si Ming, Kam, Cathelijne, van Loon, Lex M, Poh, Perlita, Ferreira, Rita, Mann, Graham J, Gruen, Russell L, Hannan, Katherine M, Hannan, Ross D, Schulte, Klaus-Martin
Publicado 2023

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

por Kusnadi, Eric P, Trigos, Anna S, Cullinane, Carleen, Goode, David L, Larsson, Ola, Devlin, Jennifer R, Chan, Keefe T, De Souza, David P, McConville, Malcolm J, McArthur, Grant A, Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D, Hannan, Katherine M, Kang, Jian, Pearson, Richard B
Publicado 2020

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

por Quin, Jaclyn, Chan, Keefe T., Devlin, Jennifer R., Cameron, Donald P., Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J., Hannan, Katherine M, Poortinga, Gretchen, Sheppard, Karen E., Khanna, Kum Kum, Johnstone, Ricky W., Drygin, Denis, McArthur, Grant A., Pearson, Richard B., Sanij, Elaine, Hannan, Ross D.
Publicado 2016

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

por Boglev, Yeliz, Badrock, Andrew P., Trotter, Andrew J., Du, Qian, Richardson, Elsbeth J., Parslow, Adam C., Markmiller, Sebastian J., Hall, Nathan E., de Jong-Curtain, Tanya A., Ng, Annie Y., Verkade, Heather, Ober, Elke A., Field, Holly A., Shin, Donghun, Shin, Chong H., Hannan, Katherine M., Hannan, Ross D., Pearson, Richard B., Kim, Seok-Hyung, Ess, Kevin C., Lieschke, Graham J., Stainier, Didier Y. R., Heath, Joan K.
Publicado 2013

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

por Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
Publicado 2020

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

por Liu, Pei Y., Tee, Andrew E., Milazzo, Giorgio, Hannan, Katherine M., Maag, Jesper, Mondal, Sujanna, Atmadibrata, Bernard, Bartonicek, Nenad, Peng, Hui, Ho, Nicholas, Mayoh, Chelsea, Ciaccio, Roberto, Sun, Yuting, Henderson, Michelle J., Gao, Jixuan, Everaert, Celine, Hulme, Amy J., Wong, Matthew, Lan, Qing, Cheung, Belamy B., Shi, Leming, Wang, Jenny Y., Simon, Thorsten, Fischer, Matthias, Zhang, Xu D., Marshall, Glenn M., Norris, Murray D., Haber, Michelle, Vandesompele, Jo, Li, Jinyan, Mestdagh, Pieter, Hannan, Ross D., Dinger, Marcel E., Perini, Giovanni, Liu, Tao
Publicado 2019

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

por Thejer, Bashar M., Adhikary, Partho P., Kaur, Amandeep, Teakel, Sarah L., Van Oosterum, Ashleigh, Seth, Ishith, Pajic, Marina, Hannan, Katherine M., Pavy, Megan, Poh, Perlita, Jazayeri, Jalal A., Zaw, Thiri, Pascovici, Dana, Ludescher, Marina, Pawlak, Michael, Cassano, Juan C., Turnbull, Lynne, Jazayeri, Mitra, James, Alexander C., Coorey, Craig P., Roberts, Tara L., Kinder, Simon J., Hannan, Ross D., Patrick, Ellis, Molloy, Mark P., New, Elizabeth J., Fehm, Tanja N., Neubauer, Hans, Goldys, Ewa M., Weston, Leslie A., Cahill, Michael A.
Publicado 2020

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

por Hannan, Katherine M., Soo, Priscilla, Wong, Mei S., Lee, Justine K., Hein, Nadine, Poh, Perlita, Wysoke, Kira D., Williams, Tobias D., Montellese, Christian, Smith, Lorey K., Al-Obaidi, Sheren J., Núñez-Villacís, Lorena, Pavy, Megan, He, Jin-Shu, Parsons, Kate M., Loring, Karagh E., Morrison, Tess, Diesch, Jeannine, Burgio, Gaetan, Ferreira, Rita, Feng, Zhi-Ping, Gould, Cathryn M., Madhamshettiwar, Piyush B., Flygare, Johan, Gonda, Thomas J., Simpson, Kaylene J., Kutay, Ulrike, Pearson, Richard B., Engel, Christoph, Watkins, Nicholas J., Hannan, Ross D., George, Amee J.
Publicado 2022