Is the Injectable Contraceptive Depo-Medroxyprogesterone Acetate (DMPA-IM) Associated with an Increased Risk for HIV Acquisition? The Jury Is Still Out

por Hapgood, Janet P.
Publicado 2020

Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms

por Hapgood, Janet P., Kaushic, Charu, Hel, Zdenek
Publicado 2018

Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model

por Robertson, Steven, Rohwer, Johann M., Hapgood, Janet P., Louw, Ann
Publicado 2013

The Progestin-Only Contraceptive Medroxyprogesterone Acetate, but Not Norethisterone Acetate, Enhances HIV-1 Vpr-Mediated Apoptosis in Human CD4(+) T Cells through the Glucocortico...

por Tomasicchio, Michele, Avenant, Chanel, Du Toit, Andrea, Ray, Roslyn M., Hapgood, Janet P.
Publicado 2013

Increased HIV‐1 infection in PBMCs treated in vitro with menstrual cycle phase hormones or medroxyprogesterone acetate likely occurs via different mechanisms

por Bick, Alexis J., Avenant, Chanel, Tomasicchio, Michele, van der Spuy, Zephne, Hapgood, Janet P.
Publicado 2022

Inhibition of Corticosteroid-Binding Globulin Gene Expression by Glucocorticoids Involves C/EBPβ

por Verhoog, Nicolette, Allie-Reid, Fatima, Vanden Berghe, Wim, Smith, Carine, Haegeman, Guy, Hapgood, Janet, Louw, Ann
Publicado 2014

Pharmacokinetic, biologic and epidemiologic differences in MPA- and NET-based progestin-only injectable contraceptives relative to the potential impact on HIV acquisition in women(...

por Heffron, Renee, Achilles, Sharon L., Dorflinger, Laneta J., Hapgood, Janet P., Kiarie, James, Polis, Chelsea B., Steyn, Petrus S.
Publicado 2019

The Injectable-Only Contraceptive Medroxyprogesterone Acetate, Unlike Norethisterone Acetate and Progesterone, Regulates Inflammatory Genes in Endocervical Cells via the Glucocorti...

por Govender, Yashini, Avenant, Chanel, Verhoog, Nicolette J. D., Ray, Roslyn M., Grantham, Nicholas J., Africander, Donita, Hapgood, Janet P.
Publicado 2014

The contraceptive medroxyprogesterone acetate, unlike norethisterone, directly increases R5 HIV-1 infection in human cervical explant tissue at physiologically relevant concentrati...

por Ray, Roslyn M., Maritz, Michelle F., Avenant, Chanel, Tomasicchio, Michele, Dlamini, Sigcinile, van der Spuy, Zephne, Hapgood, Janet P.
Publicado 2019

The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates Mycobacterium tuberculosis–Specific Host Immunity Through the Glucocorticoid Receptor

por Tomasicchio, Michele, Davids, Malika, Pooran, Anil, Theron, Grant, Smith, Liezel, Semple, Lynn, Meldau, Richard, Hapgood, Janet Patricia, Dheda, Keertan
Publicado 2019

Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the...

por Maritz, Michelle F., Ray, Roslyn M., Bick, Alexis J., Tomasicchio, Michele, Woodland, John G., Govender, Yashini, Avenant, Chanel, Hapgood, Janet P.
Publicado 2018