Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity

por Cole, Daniel J., Rajendra, Eeson, Roberts-Thomson, Meredith, Hardwick, Bryn, McKenzie, Grahame J., Payne, Mike C., Venkitaraman, Ashok R., Skylaris, Chris-Kriton
Publicado 2011

Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation

por Huggins, David J., McKenzie, Grahame J., Robinson, Daniel D., Narváez, Ana J., Hardwick, Bryn, Roberts-Thomson, Meredith, Venkitaraman, Ashok R., Grant, Guy H., Payne, Mike C.
Publicado 2010

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

por Sharma, Pooja, Mahen, Robert, Rossmann, Maxim, Stokes, Jamie E., Hardwick, Bryn, Huggins, David J., Emery, Amy, Kunciw, Dominique L., Hyvönen, Marko, Spring, David R., McKenzie, Grahame J., Venkitaraman, Ashok R.
Publicado 2019

The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis

por Roche-Molina, Marta, Hardwick, Bryn, Sanchez-Ramos, Cristina, Sanz-Rosa, David, Gewert, Dirk, Cruz, Francisco M., Gonzalez-Guerra, Andres, Andres, Vicente, Palma, Joaquin A., Ibanez, Borja, Mckenzie, Grahame, Bernal, Juan A.
Publicado 2020

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

por Janeček, Matej, Rossmann, Maxim, Sharma, Pooja, Emery, Amy, Huggins, David J., Stockwell, Simon R., Stokes, Jamie E., Tan, Yaw S., Almeida, Estrella Guarino, Hardwick, Bryn, Narvaez, Ana J., Hyvönen, Marko, Spring, David R., McKenzie, Grahame J., Venkitaraman, Ashok R.
Publicado 2016

Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

por Huggins, David J., Hardwick, Bryn S., Sharma, Pooja, Emery, Amy, Laraia, Luca, Zhang, Fengzhi, Narvaez, Ana J., Roberts-Thomson, Meredith, Crooks, Alex T., Boyle, Robert G., Boyce, Richard, Walker, David W., Mateu, Natalia, McKenzie, Grahame J., Spring, David R., Venkitaraman, Ashok R.
Publicado 2019

Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

por Emery, Amy, Hardwick, Bryn S., Crooks, Alex T., Milech, Nadia, Watt, Paul M., Mithra, Chandan, Kumar, Vikrant, Giridharan, Saranya, Sadasivam, Gayathri, Mathivanan, Subashini, Sudhakar, Sneha, Bairy, Sneha, Bharatham, Kavitha, Hurakadli, Manjunath A., Prasad, Thazhe K., Kamariah, Neelagandan, Muellner, Markus, Coelho, Miguel, Torrance, Christopher J., McKenzie, Grahame J., Venkitaraman, Ashok R.
Publicado 2021

Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS

por Narvaez, Ana J., Ber, Suzan, Crooks, Alex, Emery, Amy, Hardwick, Bryn, Guarino Almeida, Estrella, Huggins, David J., Perera, David, Roberts-Thomson, Meredith, Azzarelli, Roberta, Hood, Fiona E., Prior, Ian A., Walker, David W., Boyce, Richard, Boyle, Robert G., Barker, Samuel P., Torrance, Christopher J., McKenzie, Grahame J., Venkitaraman, Ashok R.
Publicado 2017

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

por Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., Abell, Chris
Publicado 2021