The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

por Hardy, Rachel E., Chung, Injae, Yu, Yizhou, Loh, Samantha H. Y., Morone, Nobuhiro, Soleilhavoup, Clement, Travaglio, Marco, Serreli, Riccardo, Panman, Lia, Cain, Kelvin, Hirst, Judy, Martins, Luis M., MacFarlane, Marion, Pryde, Kenneth R.
Publicado 2023

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

por Stephenson, Zoe A, Harvey, Robert F, Pryde, Kenneth R, Mistry, Sarah, Hardy, Rachel E, Serreli, Riccardo, Chung, Injae, Allen, Timothy EH, Stoneley, Mark, MacFarlane, Marion, Fischer, Peter M, Hirst, Judy, Kellam, Barrie, Willis, Anne E
Publicado 2020