Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

por Miller, Laurence J., Harikumar, Kaleeckal G., Wootten, Denise, Sexton, Patrick M.
Publicado 2021

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus

por Ng, Hans K. H., Harikumar, Kaleeckal G., Miller, Laurence J., Chow, Billy K. C.
Publicado 2016

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

por Ward, Richard J., Pediani, John D., Harikumar, Kaleeckal G., Miller, Laurence J., Milligan, Graeme
Publicado 2017

Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors

por Sarkar, Parijat, Harikumar, Kaleeckal G., Rawat, Satinder S., Das, Sanjib, Chakraborty, Tushar K., Chattopadhyay, Amitabha
Publicado 2021

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

por Dengler, Daniela G., Sun, Qing, Harikumar, Kaleeckal G., Miller, Laurence J., Sergienko, Eduard A.
Publicado 2022

Mechanism of Action and Structure–Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

por Dengler, Daniela G., Harikumar, Kaleeckal G., Yen, Alice, Sergienko, Eduard A., Miller, Laurence J.
Publicado 2023

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

por Yan, Yan, Xu, Ting-Hai, Harikumar, Kaleeckal G., Miller, Laurence J., Melcher, Karsten, Xu, H. Eric
Publicado 2017

Modulation of β-Catenin Signaling by Glucagon Receptor Activation

por Ke, Jiyuan, Zhang, Chenghai, Harikumar, Kaleeckal G., Zylstra-Diegel, Cassandra R., Wang, Liren, Mowry, Laura E., Miller, Laurence J., Williams, Bart O., Xu, H. Eric
Publicado 2012

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

por DeBruine, Zachary J., Ke, Jiyuan, Harikumar, Kaleeckal G., Gu, Xin, Borowsky, Peter, Williams, Bart O., Xu, Wenqing, Miller, Laurence J., Xu, H. Eric, Melcher, Karsten
Publicado 2017

Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex

por Ke, Jiyuan, Harikumar, Kaleeckal G., Erice, Clara, Chen, Chen, Gu, Xin, Wang, Liren, Parker, Naomi, Cheng, Zhihong, Xu, Wenqing, Williams, Bart O., Melcher, Karsten, Miller, Laurence J., Xu, H. Eric
Publicado 2013

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

por Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M., Miller, Laurence J.
Publicado 2021

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

por Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Publicado 2021

Structure and dynamics of the active Gs-coupled human secretin receptor

por Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Publicado 2020