Rapidly Deployable Mouse Models of SARS-CoV-2 Infection Add Flexibility to the COVID-19 Toolbox

por Harker, James A., Johansson, Cecilia
Publicado 2021

T helper 2 cells in asthma

por Harker, James A., Lloyd, Clare M.
Publicado 2023

Immunological fortification at our barrier organs: Protecting us as we age

por Harker, James A., Pallett, Laura J.
Publicado 2020

A Not-So-Good Way to Die? Respiratory Syncytial Virus–induced Necroptotic Cell Death Promotes Inflammation and Type 2–mediated Pathology

por Harker, James A., Snelgrove, Robert J.
Publicado 2020

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

por Pyle, Chloe J., Uwadiae, Faith I., Swieboda, David P., Harker, James A.
Publicado 2017

Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System

por Harker, James A., Yamaguchi, Yuko, Culley, Fiona J., Tregoning, John S., Openshaw, Peter J. M.
Publicado 2014

IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection

por Harker, James A., Greene, Trever T., Barnett, Burton E., Bao, Phuc, Dolgoter, Aleksandr, Zuniga, Elina I.
Publicado 2023

Targeting the ICOS/ICOS‐L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

por Uwadiae, Faith I., Pyle, Chloe J., Walker, Simone A., Lloyd, Clare M., Harker, James A.
Publicado 2018

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses

por Taylor, Alison, Harker, James A., Chanthong, Kittiphat, Stevenson, Philip G., Zuniga, Elina I., Rudd, Christopher E.
Publicado 2016

Enhanced IL-2 in early life limits the development of T(FH) and protective antiviral immunity

por Pyle, Chloe J., Labeur-Iurman, Lucia, Groves, Helen T., Puttur, Franz, Lloyd, Clare M., Tregoning, John S., Harker, James A.
Publicado 2021

Autoantibodies are present in the bronchoalveolar lavage but not circulation in patients with fibrotic interstitial lung disease

por Boustani, Karim, Ghai, Poonam, Invernizzi, Rachele, Hewitt, Richard J., Maher, Toby M., Li, Quan-Zhen, Molyneaux, Philip L., Harker, James A.
Publicado 2022

Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection

por Harker, James A., Wong, Kurt A., Dallari, Simone, Bao, Phuc, Dolgoter, Aleksandr, Jo, Yeara, Wehrens, Ellen J., Macal, Monica, Zuniga, Elina I.
Publicado 2018

Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration

por Beloueche-Babari, Mounia, Casals Galobart, Teresa, Delgado-Goni, Teresa, Wantuch, Slawomir, Parkes, Harold G., Tandy, Debbie, Harker, James A., Leach, Martin O.
Publicado 2020

Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection

por Peiró, Teresa, Patel, Dhiren F, Akthar, Samia, Gregory, Lisa G, Pyle, Chloe J, Harker, James A, Birrell, Mark A, Lloyd, Clare M, Snelgrove, Robert J
Publicado 2018

Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic E. coli Challenge

por Juzenaite, Goda, Secklehner, Judith, Vuononvirta, Juho, Helbawi, Yoseph, Mackey, John B. G., Dean, Charlotte, Harker, James A., Carlin, Leo M., Rankin, Sara, De Filippo, Katia
Publicado 2021

Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma

por Pyle, Chloe J., Patel, Dhiren F., Peiró, Teresa, Joulia, Régis, Grabiec, Aleksander M., Hussell, Tracy, Tavernier, Gael, Simpson, Angela, Pease, James, Harker, James A., Lloyd, Clare M., Snelgrove, Robert J.
Publicado 2022

Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccines

por Elliott, Tamara, Cheeseman, Hannah M., Evans, Abbey B., Day, Suzanne, McFarlane, Leon R., O’Hara, Jessica, Kalyan, Mohini, Amini, Fahimah, Cole, Tom, Winston, Alan, Fidler, Sarah, Pollock, Katrina M., Harker, James A., Shattock, Robin J.
Publicado 2022

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

por Vijayakumar, Bavithra, Boustani, Karim, Ogger, Patricia P., Papadaki, Artemis, Tonkin, James, Orton, Christopher M., Ghai, Poonam, Suveizdyte, Kornelija, Hewitt, Richard J., Desai, Sujal R., Devaraj, Anand, Snelgrove, Robert J., Molyneaux, Philip L., Garner, Justin L., Peters, James E., Shah, Pallav L., Lloyd, Clare M., Harker, James A.
Publicado 2022