Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans

por Harley, Isaac T. W., Allison, Kristen, Scofield, R. Hal
Publicado 2022

Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice

por Banach, Maureen, Harley, Isaac T. W., Getahun, Andrew, Cambier, John C.
Publicado 2022

Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21

por Harris, Valerie M., Harley, Isaac T. W., Kurien, Biji T., Koelsch, Kristi A., Scofield, Robert Hal
Publicado 2019

Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors

por Crute, Bergren W., Sheraden, Rachel, Ott, Vanessa L., Harley, Isaac T. W., Getahun, Andrew, Cambier, John C.
Publicado 2020

Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus

por Chau, Karen, Raksadawan, Yanint, Allison, Kristen, Ice, John A., Scofield, Robert Hal, Chepelev, Iouri, Harley, Isaac T. W.
Publicado 2023

Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis

por Harris, Valerie M., Koelsch, Kristi A., Kurien, Biji T., Harley, Isaac T. W., Wren, Jonathan D., Harley, John B., Scofield, R. Hal
Publicado 2019

The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population

por Namjou, Bahram, Ni, Yizhao, Harley, Isaac T. W., Chepelev, Iouri, Cobb, Beth, Kottyan, Leah C., Gaffney, Patrick M., Guthridge, Joel M., Kaufman, Kenneth, Harley, John B.
Publicado 2014

Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation

por McAlees, Jaclyn W., Whitehead, Gregory S., Harley, Isaac T.W., Cappelletti, Monica, Rewerts, Cheryl L., Holdcroft, A. Maria, Divanovic, Senad, Wills-Karp, Marsha, Finkelman, Fred D., Karp, Christopher L., Cook, Donald N.
Publicado 2014

Osteopontin and Systemic Lupus Erythematosus Association: A Probable Gene-Gender Interaction

por Han, Shizhong, Guthridge, Joel M., Harley, Isaac T. W., Sestak, Andrea L., Kim-Howard, Xana, Kaufman, Kenneth M., Namjou, Bahram, Deshmukh, Harshal, Bruner, Gail, Espinoza, Luis R., Gilkeson, Gary S., Harley, John B., James, Judith A., Nath, Swapan K.
Publicado 2008

SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

por Hou, Guojun, Harley, Isaac T. W., Lu, Xiaoming, Zhou, Tian, Xu, Ning, Yao, Chao, Qin, Yuting, Ouyang, Ye, Ma, Jianyang, Zhu, Xinyi, Yu, Xiang, Xu, Hong, Dai, Dai, Ding, Huihua, Yin, Zhihua, Ye, Zhizhong, Deng, Jun, Zhou, Mi, Tang, Yuanjia, Namjou, Bahram, Guo, Ya, Weirauch, Matthew T., Kottyan, Leah C., Harley, John B., Shen, Nan
Publicado 2021

IFRD1 polymorphisms in cystic fibrosis with potential link to altered neutrophil function

por Gu, YuanYuan, Harley, Isaac T. W., Henderson, Lindsay B., Aronow, Bruce J., Vietor, Ilja, Huber, Lukas A., Harley, John B., Kilpatrick, Jeffrey R., Langefeld, Carl D., Williams, Adrienne H., Jegga, Anil G., Chen, Jing, Wills-Karp, Marsha, Arshad, S. Hasan, Ewart, Susan L., Thio, Chloe L., Flick, Leah M., Filippi, Marie-Dominique, Grimes, H. Leighton, Drumm, Mitchell L., Cutting, Garry R., Knowles, Michael R., Karp, Christopher L.
Publicado 2009

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain

por Chan, Calvin C., Harley, Isaac T. W., Pfluger, Paul T., Trompette, Aurelien, Stankiewicz, Traci E., Allen, Jessica L., Moreno-Fernandez, Maria E., Damen, Michelle S. M. A., Oates, Jarren R., Alarcon, Pablo C., Doll, Jessica R., Flick, Matthew J., Flick, Leah M., Sanchez-Gurmaches, Joan, Mukherjee, Rajib, Karns, Rebekah, Helmrath, Michael, Inge, Thomas H., Weisberg, Stuart P., Pamp, Sünje J., Relman, David A., Seeley, Randy J., Tschöp, Matthias H., Karp, Christopher L., Divanovic, Senad
Publicado 2021

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

por Namjou, Bahram, Lingren, Todd, Huang, Yongbo, Parameswaran, Sreeja, Cobb, Beth L., Stanaway, Ian B., Connolly, John J., Mentch, Frank D., Benoit, Barbara, Niu, Xinnan, Wei, Wei-Qi, Carroll, Robert J., Pacheco, Jennifer A., Harley, Isaac T. W., Divanovic, Senad, Carrell, David S., Larson, Eric B., Carey, David J., Verma, Shefali, Ritchie, Marylyn D., Gharavi, Ali G., Murphy, Shawn, Williams, Marc S., Crosslin, David R., Jarvik, Gail P., Kullo, Iftikhar J., Hakonarson, Hakon, Li, Rongling, Xanthakos, Stavra A., Harley, John B.
Publicado 2019

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

por Harley, Isaac T. W., Niewold, Timothy B., Stormont, Rebecca M., Kaufman, Kenneth M., Glenn, Stuart B., Franek, Beverly S., Kelly, Jennifer A., Kilpatrick, Jeffrey R., Hutchings, David, Divers, Jasmin, Bruner, Gail R., Edberg, Jeffrey C., McGwin, Gerald, Petri, Michelle A., Ramsey-Goldman, Rosalind, Reveille, John D., Vilá-Pérez, Luis M., Merrill, Joan T., Gilkeson, Gary S., Vyse, Timothy J., Alarcón-Riquelme, Marta E., Cho, Soo-Kyung, Jacob, Chaim O., Alarcón, Graciela S., Moser, Kathy L., Gaffney, Patrick M., Kimberly, Robert P., Bae, Sang-Cheol, Langefeld, Carl D., Harley, John B., Guthridge, Joel M., James, Judith A.
Publicado 2010

Lupus risk variants in the PXK locus alter B-cell receptor internalization

por Vaughn, Samuel E., Foley, Corinne, Lu, Xiaoming, Patel, Zubin H., Zoller, Erin E., Magnusen, Albert F., Williams, Adrienne H., Ziegler, Julie T., Comeau, Mary E., Marion, Miranda C., Glenn, Stuart B., Adler, Adam, Shen, Nan, Nath, Swapan, Stevens, Anne M., Freedman, Barry I., Tsao, Betty P., Jacob, Chaim O., Kamen, Diane L., Brown, Elizabeth E., Gilkeson, Gary S., Alarcón, Graciela S., Reveille, John D., Anaya, Juan-Manuel, James, Judith A., Moser, Kathy L., Criswell, Lindsey A., Vilá, Luis M., Alarcón-Riquelme, Marta E., Petri, Michelle, Scofield, R. Hal, Kimberly, Robert P., Ramsey-Goldman, Rosalind, Binjoo, Young, Choi, Jeongim, Bae, Sang-Cheol, Boackle, Susan A., Vyse, Timothy J., Guthridge, Joel M., Namjou, Bahram, Gaffney, Patrick M., Langefeld, Carl D., Kaufman, Kenneth M., Kelly, Jennifer A., Harley, Isaac T. W., Harley, John B., Kottyan, Leah C.
Publicado 2015