Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens

por Harmer, Nicholas J., Chahwan, Richard
Publicado 2016

A half-site multimeric enzyme achieves its cooperativity without conformational changes

por Vivoli, Mirella, Pang, Jiayun, Harmer, Nicholas J.
Publicado 2017

Woronin body-based sealing of septal pores

por Steinberg, Gero, Harmer, Nicholas J., Schuster, Martin, Kilaru, Sreedhar
Publicado 2017

A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity

por Sheppard, Emily C., Rogers, Sally, Harmer, Nicholas J., Chahwan, Richard
Publicado 2019

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

por Vivoli, Mirella, Novak, Halina R., Littlechild, Jennifer A., Harmer, Nicholas J.
Publicado 2014

Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme

por Vivoli, Mirella, Ayres, Emily, Beaumont, Edward, Isupov, Michail N., Harmer, Nicholas J.
Publicado 2013

Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction

por Thomas, Adam, Cutlan, Rhys, Finnigan, William, van der Giezen, Mark, Harmer, Nicholas
Publicado 2019

Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase

por Schuster, Martin, Treitschke, Steffi, Kilaru, Sreedhar, Molloy, Justin, Harmer, Nicholas J, Steinberg, Gero
Publicado 2012

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors

por Blaszczyk, Michal, Harmer, Nicholas J., Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L.
Publicado 2015

Engineering a Seven Enzyme Biotransformation using Mathematical Modelling and Characterized Enzyme Parts

por Finnigan, William, Cutlan, Rhys, Snajdrova, Radka, Adams, Joseph P., Littlechild, Jennifer A., Harmer, Nicholas J.
Publicado 2019

Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species

por Barker, Sam, Harding, Sarah V., Gray, David, Richards, Mark I., Atkins, Helen S., Harmer, Nicholas J.
Publicado 2021

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

por Butt, Aaron, Higman, Victoria A., Williams, Christopher, Crump, Matthew P., Hemsley, Claudia M., Harmer, Nicholas, Titball, Richard W.
Publicado 2014

Zoonoses under our noses

por Cross, Alice R., Baldwin, Victoria M., Roy, Sumita, Essex-Lopresti, Angela E., Prior, Joann L., Harmer, Nicholas J.
Publicado 2019

Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry

por Finnigan, William, Thomas, Adam, Cromar, Holly, Gough, Ben, Snajdrova, Radka, Adams, Joseph P., Littlechild, Jennifer A., Harmer, Nicholas J.
Publicado 2017

The ROK kinase N-acetylglucosamine kinase uses a sequential random enzyme mechanism with successive conformational changes upon each substrate binding

por Roy, Sumita, Vivoli Vega, Mirella, Ames, Jessica R., Britten, Nicole, Kent, Amy, Evans, Kim, Isupov, Michail N., Harmer, Nicholas J.
Publicado 2023

Structural characterization of a novel cyclic 2,3-diphosphoglycerate synthetase involved in extremolyte production in the archaeon Methanothermus fervidus

por De Rose, Simone A., Isupov, Michail N., Worthy, Harley L., Stracke, Christina, Harmer, Nicholas J., Siebers, Bettina, Littlechild, Jennifer A.
Publicado 2023

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery

por Vivoli, Mirella, Isupov, Michail N., Nicholas, Rebecca, Hill, Andrew, Scott, Andrew E., Kosma, Paul, Prior, Joann L., Harmer, Nicholas J.
Publicado 2015

Predicting Protein Function from Structure—The Roles of Short-chain Dehydrogenase/Reductase Enzymes in Bordetella O-antigen Biosynthesis

por King, Jerry D., Harmer, Nicholas J., Preston, Andrew, Palmer, Colin M., Rejzek, Martin, Field, Robert A., Blundell, Tom L., Maskell, Duncan J.
Publicado 2007

Structural characterisation of the capsular polysaccharide expressed by Burkholderia thailandensis strain E555:: wbiI (pKnock-KmR) and assessment of the significance of the 2-O-ace...

por Bayliss, Marc, Donaldson, Matthew I., Nepogodiev, Sergey A., Pergolizzi, Giulia, Scott, Andrew E., Harmer, Nicholas J., Field, Robert A., Prior, Joann L.
Publicado 2017

Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile

por Bradshaw, William J., Bruxelle, Jean-François, Kovacs-Simon, Andrea, Harmer, Nicholas J., Janoir, Claire, Péchiné, Severine, Acharya, K. Ravi, Michell, Stephen L.
Publicado 2019