Historical contingency and its biophysical basis in glucocorticoid receptor evolution

por Harms, Michael J., Thornton, Joseph W.
Publicado 2014

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

por Sailer, Zachary R., Harms, Michael J.
Publicado 2017

High-order epistasis shapes evolutionary trajectories

por Sailer, Zachary R., Harms, Michael J.
Publicado 2017

Molecular ensembles make evolution unpredictable

por Sailer, Zachary R., Harms, Michael J.
Publicado 2017

Human S100A5 binds Ca(2+) and Cu(2+) independently

por Wheeler, Lucas C., Harms, Michael J.
Publicado 2017

Were Ancestral Proteins Less Specific?

por Wheeler, Lucas C, Harms, Michael J
Publicado 2021

Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide

por Loes, Andrea N., Bridgham, Jamie T., Harms, Michael J.
Publicado 2018

Ensemble epistasis: thermodynamic origins of nonadditivity between mutations

por Morrison, Anneliese J, Wonderlick, Daria R, Harms, Michael J
Publicado 2021

Multiple Evolutionary Origins of Ubiquitous Cu(2+) and Zn(2+) Binding in the S100 Protein Family

por Wheeler, Lucas C., Donor, Micah T., Prell, James S., Harms, Michael J.
Publicado 2016

Higher-order interactions shape microbial interactions as microbial community complexity increases

por Morin, Manon A., Morrison, Anneliese J., Harms, Michael J., Dutton, Rachel J.
Publicado 2022

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty

por Eick, Geeta N., Bridgham, Jamie T., Anderson, Douglas P., Harms, Michael J., Thornton, Joseph W.
Publicado 2016

Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain

por Lupo, Brianna E., Chu, Peirou, Harms, Michael J., Morrison, Emma A., Musselman, Catherine A.
Publicado 2021

Simultaneous Mapping of DNA Binding and Nucleosome Positioning with SpLiT-ChEC

por Banks, Orion G. B., Harms, Michael J., McKnight, Jeffrey. N., McKnight, Laura E.
Publicado 2023

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

por Eick, Geeta N., Colucci, Jennifer K., Harms, Michael J., Ortlund, Eric A., Thornton, Joseph W.
Publicado 2012

A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family

por Jain, Rohit, Muneeruddin, Khaja, Anderson, Jeremy, Harms, Michael J., Shaffer, Scott A., Matthews, C. Robert
Publicado 2021

Thermodynamic System Drift in Protein Evolution

por Hart, Kathryn M., Harms, Michael J., Schmidt, Bryan H., Elya, Carolyn, Thornton, Joseph W., Marqusee, Susan
Publicado 2014

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

por Harman, Joseph L, Loes, Andrea N, Warren, Gus D, Heaphy, Maureen C, Lampi, Kirsten J, Harms, Michael J
Publicado 2020

Inferring a complete genotype-phenotype map from a small number of measured phenotypes

por Sailer, Zachary R., Shafik, Sarah H., Summers, Robert L., Joule, Alex, Patterson-Robert, Alice, Martin, Rowena E., Harms, Michael J.
Publicado 2020

Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

por Harman, Joseph L., Reardon, Patrick N., Costello, Shawn M., Warren, Gus D., Phillips, Sophia R., Connor, Patrick J., Marqusee, Susan, Harms, Michael J.
Publicado 2022

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

por Bridgham, Jamie T., Eick, Geeta N., Larroux, Claire, Deshpande, Kirti, Harms, Michael J., Gauthier, Marie E. A., Ortlund, Eric A., Degnan, Bernard M., Thornton, Joseph W.
Publicado 2010