Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography

por Harp, Joel M, Coates, Leighton, Sullivan, Brendan, Egli, Martin
Publicado 2021

Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs

por Patra, Amritraj, Harp, Joel, Pallan, Pradeep S., Zhao, Linlin, Abramov, Mikhail, Herdewijn, Piet, Egli, Martin
Publicado 2013

Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure

por Harp, Joel M, Lybrand, Terry P, Pallan, Pradeep S, Coates, Leighton, Sullivan, Brendan, Egli, Martin
Publicado 2022

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase

por Tomar, Rachana, Minko, Irina G, Sharma, Pankaj, Kellum, Andrew H, Lei, Li, Harp, Joel M, Iverson, T M, Lloyd, R Stephen, Egli, Martin, Stone, Michael P
Publicado 2023

Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus

por Thompson, Matthew K., Keithly, Mary E., Goodman, Michael C., Hammer, Neal D., Cook, Paul D., Jagessar, Kevin L., Harp, Joel, Skaar, Eric P., Armstrong, Richard N.
Publicado 2014

Computational redesign of a fluorogen activating protein with Rosetta

por Bozhanova, Nina G., Harp, Joel M., Bender, Brian J., Gavrikov, Alexey S., Gorbachev, Dmitry A., Baranov, Mikhail S., Mercado, Christina B., Zhang, Xuan, Lukyanov, Konstantin A., Mishin, Alexander S., Meiler, Jens
Publicado 2021

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs

por Schlegel, Mark K, Matsuda, Shigeo, Brown, Christopher R, Harp, Joel M, Barry, Joseph D, Berman, Daniel, Castoreno, Adam, Schofield, Sally, Szeto, John, Manoharan, Muthiah, Charissé, Klaus, Egli, Martin, Maier, Martin A
Publicado 2021

Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

por Harp, Joel M, Guenther, Dale C, Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R, Zlatev, Ivan, Foster, Donald J, Taneja, Nate, Charisse, Klaus, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Egli, Martin
Publicado 2018

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activit...

por Kumar, Pawan, Degaonkar, Rohan, Guenther, Dale C, Abramov, Mikhail, Schepers, Guy, Capobianco, Marie, Jiang, Yongfeng, Harp, Joel, Kaittanis, Charalambos, Janas, Maja M, Castoreno, Adam, Zlatev, Ivan, Schlegel, Mark K, Herdewijn, Piet, Egli, Martin, Manoharan, Muthiah
Publicado 2020