Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

por Harpsøe, Kasper, Boesgaard, Michael W, Munk, Christian, Bräuner-Osborne, Hans, Gloriam, David E
Publicado 2017

A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

por Nakamoto, Chihiro, Goto, Yuhei, Tomizawa, Yoko, Fukata, Yuko, Fukata, Masaki, Harpsøe, Kasper, Gloriam, David E., Aoki, Kazuhiro, Takeuchi, Tomonori
Publicado 2021

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

por Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G., Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H., Bräuner-Osborne, Hans, Gloriam, David E.
Publicado 2015

GPCRdb in 2018: adding GPCR structure models and ligands

por Pándy-Szekeres, Gáspár, Munk, Christian, Tsonkov, Tsonko M, Mordalski, Stefan, Harpsøe, Kasper, Hauser, Alexander S, Bojarski, Andrzej J, Gloriam, David E
Publicado 2018

GPCRdb: an information system for G protein-coupled receptors

por Isberg, Vignir, Mordalski, Stefan, Munk, Christian, Rataj, Krzysztof, Harpsøe, Kasper, Hauser, Alexander S., Vroling, Bas, Bojarski, Andrzej J., Vriend, Gert, Gloriam, David E.
Publicado 2016

GPCRdb: an information system for G protein-coupled receptors

por Isberg, Vignir, Mordalski, Stefan, Munk, Christian, Rataj, Krzysztof, Harpsøe, Kasper, Hauser, Alexander S., Vroling, Bas, Bojarski, Andrzej J., Vriend, Gert, Gloriam, David E.
Publicado 2017

Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA(A) receptors

por Falk-Petersen, Christina Birkedahl, Tsonkov, Tsonko M., Nielsen, Malene Sofie, Harpsøe, Kasper, Bundgaard, Christoffer, Frølund, Bente, Kristiansen, Uffe, Gloriam, David E., Wellendorph, Petrine
Publicado 2020

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

por Shehata, Mohamed A., Nøhr, Anne C., Lissa, Delphine, Bisig, Christoph, Isberg, Vignir, Andersen, Kirsten B., Harpsøe, Kasper, Björkling, Fredrik, Bräuner-Osborne, Hans, Gloriam, David E.
Publicado 2016

Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT(2A) Receptor Agonists

por Pottie, Eline, Poulie, Christian B. M., Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper L., Stove, Christophe P.
Publicado 2023

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT(2A) Receptor Agonists

por Poulie, Christian B. M., Pottie, Eline, Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Stove, Christophe P., Kristensen, Jesper L.
Publicado 2022

Development of a human vasopressin V(1a)-receptor antagonist from an evolutionary-related insect neuropeptide

por Di Giglio, Maria Giulia, Muttenthaler, Markus, Harpsøe, Kasper, Liutkeviciute, Zita, Keov, Peter, Eder, Thomas, Rattei, Thomas, Arrowsmith, Sarah, Wray, Susan, Marek, Ales, Elbert, Tomas, Alewood, Paul F., Gloriam, David E., Gruber, Christian W.
Publicado 2017

Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

por Zhou, Yali, Daver, Henrik, Trapkov, Boris, Wu, Lijie, Wu, Meng, Harpsøe, Kasper, Gentry, Patrick R., Liu, Kaiwen, Larionova, Marina, Liu, Junlin, Chen, Na, Bräuner-Osborne, Hans, Gloriam, David E., Hua, Tian, Liu, Zhi-Jie
Publicado 2021

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

por Malfacini, Davide, Patt, Julian, Annala, Suvi, Harpsøe, Kasper, Eryilmaz, Funda, Reher, Raphael, Crüsemann, Max, Hanke, Wiebke, Zhang, Hang, Tietze, Daniel, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian, König, Gabriele M., Inoue, Asuka, Gomeza, Jesus, Kostenis, Evi
Publicado 2019