Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer’s Disease

por Lai, Robert Y. K., Harrington, Charles R., Wischik, Claude M.
Publicado 2016

Erratum: Lai, R.Y.K.; Harrington, C.R.; Wischik, C.M. Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer’s Disease. Biomolecules 2016, 6, 19

por Lai, Robert Y. K., Harrington, Charles R., Wischik, Claude M.
Publicado 2016

Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier

por Bentham, Peter, Staff, Roger T., Schelter, Bjoern O., Shiells, Helen, Harrington, Charles R., Wischik, Claude M.
Publicado 2021

Modeling Prion-Like Processing of Tau Protein in Alzheimer’s Disease for Pharmaceutical Development

por Wischik, Claude M., Schelter, Björn O., Wischik, Damon J., Storey, John M. D., Harrington, Charles R.
Publicado 2018

Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks

por Schwab, Karima, Melis, Valeria, Harrington, Charles R., Wischik, Claude M., Magbagbeolu, Mandy, Theuring, Franz, Riedel, Gernot
Publicado 2021

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

por Arastoo, Mohammad, Lofthouse, Richard, Penny, Lewis K., Harrington, Charles R., Porter, Andy, Wischik, Claude M., Palliyil, Soumya
Publicado 2020

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

por Kondak, Constantin, Leith, Michael, Baddeley, Thomas C., Santos, Renato X., Harrington, Charles R., Wischik, Claude M., Riedel, Gernot, Klein, Jochen
Publicado 2023

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

por Maina, Mahmoud B., Al-Hilaly, Youssra K., Burra, Gunasekhar, Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Publicado 2021

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis

por Zabala-Findlay, Alex, Penny, Lewis K., Lofthouse, Richard A., Porter, Andrew J., Palliyil, Soumya, Harrington, Charles R., Wischik, Claude M., Arastoo, Mohammad
Publicado 2023

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia

por Lemke, Nora, Melis, Valeria, Lauer, Dilyara, Magbagbeolu, Mandy, Neumann, Boris, Harrington, Charles R., Riedel, Gernot, Wischik, Claude M., Theuring, Franz, Schwab, Karima
Publicado 2021

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants

por Arastoo, Mohammad, Mazanetz, Michael P., Miller, Sonya, Shiells, Helen, Hull, Claire, Robinson, Keith, Storey, John M. D., Harrington, Charles R., Wischik, Claude M.
Publicado 2023

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s disease and frontotemporal lobar degeneration

por Cranston, Anna L, Wysocka, Adrianna, Steczkowska, Marta, Zadrożny, Maciej, Palasz, Ewelina, Harrington, Charles R, Theuring, Franz, Wischik, Claude M, Riedel, Gernot, Niewiadomska, Grazyna
Publicado 2020

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

por Vuksanović, Vesna, Staff, Roger T, Morson, Suzannah, Ahearn, Trevor, Bracoud, Luc, Murray, Alison D, Bentham, Peter, Kipps, Christopher M, Harrington, Charles R, Wischik, Claude M
Publicado 2021

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

por Santos, Renato X., Melis, Valeria, Goatman, Elizabeth A., Leith, Michael, Baddeley, Thomas C., Storey, John M. D., Riedel, Gernot, Wischik, Claude M., Harrington, Charles R.
Publicado 2022

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

por Al-Hilaly, Youssra K., Hurt, Connor, Rickard, Janet E., Harrington, Charles R., Storey, John M. D., Wischik, Claude M., Serpell, Louise C., Siemer, Ansgar B.
Publicado 2022

Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells

por Pollack, Saskia J., Trigg, Jasmine, Khanom, Tahmida, Biasetti, Luca, Marshall, Karen E., Al-Hilaly, Youssra K., Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Publicado 2020

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

por Šimić, Goran, Babić Leko, Mirjana, Wray, Selina, Harrington, Charles, Delalle, Ivana, Jovanov-Milošević, Nataša, Bažadona, Danira, Buée, Luc, de Silva, Rohan, Di Giovanni, Giuseppe, Wischik, Claude, Hof, Patrick R.
Publicado 2016

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

por Al‐Hilaly, Youssra K., Foster, Bronwen E., Biasetti, Luca, Lutter, Liisa, Pollack, Saskia J., Rickard, Janet E., Storey, John M. D., Harrington, Charles R., Xue, Wei‐Feng, Wischik, Claude M., Serpell, Louise C.
Publicado 2019

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model

por Riedel, Gernot, Klein, Jochen, Niewiadomska, Grazyna, Kondak, Constantin, Schwab, Karima, Lauer, Dilyara, Magbagbeolu, Mandy, Steczkowska, Marta, Zadrozny, Maciej, Wydrych, Malgorzata, Cranston, Anna, Melis, Valeria, Santos, Renato X., Theuring, Franz, Harrington, Charles R., Wischik, Claude M.
Publicado 2020

The Neurovascular Unit Dysfunction in Alzheimer’s Disease

por Soto-Rojas, Luis O., Pacheco-Herrero, Mar, Martínez-Gómez, Paola A., Campa-Córdoba, B. Berenice, Apátiga-Pérez, Ricardo, Villegas-Rojas, Marcos M., Harrington, Charles R., de la Cruz, Fidel, Garcés-Ramírez, Linda, Luna-Muñoz, José
Publicado 2021