Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA

por Rowlands, Vicky, Rutkowski, Andrzej J., Meuser, Elena, Carr, T. Hedley, Harrington, Elizabeth A., Barrett, J. Carl
Publicado 2019

Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a trade off between quantity and quality?

por Seiler, Caroline, Sharpe, Alan, Barrett, J. Carl, Harrington, Elizabeth A., Jones, Emma V., Marshall, Gayle B.
Publicado 2016

Impact of DNA damage repair alterations on prostate cancer progression and metastasis

por Lukashchuk, Natalia, Barnicle, Alan, Adelman, Carrie A., Armenia, Joshua, Kang, Jinyu, Barrett, J. Carl, Harrington, Elizabeth A.
Publicado 2023

Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets

por Lai, Zhongwu, Brosnan, Matthew, Sokol, Ethan S., Xie, Mingchao, Dry, Jonathan R., Harrington, Elizabeth A., Barrett, J. Carl, Hodgson, Darren
Publicado 2022

Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer

por Avivar-Valderas, Alvaro, McEwen, Robert, Taheri-Ghahfarokhi, Amir, Carnevalli, Larissa S., Hardaker, Elizabeth L., Maresca, Marcello, Hudson, Kevin, Harrington, Elizabeth A., Cruzalegui, Francisco
Publicado 2018

Proliferation Tumour Marker Network (PTM-NET) for the identification of tumour region in Ki67 stained breast cancer whole slide images

por Joseph, Jesuchristopher, Roudier, Martine P., Narayanan, Priya Lakshmi, Augulis, Renaldas, Ros, Vidalba Rocher, Pritchard, Alison, Gerrard, Joe, Laurinavicius, Arvydas, Harrington, Elizabeth A., Barrett, J. Carl, Howat, William J.
Publicado 2019

Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon

por Rooney, Claire, Geh, Catherine, Williams, Victoria, Heuckmann, Johannes M., Menon, Roopika, Schneider, Petra, Al-Kadhimi, Katherine, Dymond, Michael, Smith, Neil R., Baker, Dawn, French, Tim, Smith, Paul D., Harrington, Elizabeth A., Barrett, J. Carl, Kilgour, Elaine
Publicado 2016

Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer

por Carr, T. Hedley, Adelman, Carrie, Barnicle, Alan, Kozarewa, Iwanka, Luke, Sally, Lai, Zhongwu, Hollis, Sally, Dougherty, Brian, Harrington, Elizabeth A., Kang, Jinyu, Saad, Fred, Sala, Nuria, Thiery-Vuillemin, Antoine, Clarke, Noel W., Hodgson, Darren, Barrett, J. Carl
Publicado 2021

Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound

por Chi, Kim N., Barnicle, Alan, Sibilla, Caroline, Lai, Zhongwu, Corcoran, Claire, Barrett, J. Carl, Adelman, Carrie A., Qiu, Ping, Easter, Ashley, Dearden, Simon, Oxnard, Geoffrey R., Agarwal, Neeraj, Azad, Arun, de Bono, Johann, Mateo, Joaquin, Olmos, David, Thiery-Vuillemin, Antoine, Harrington, Elizabeth A.
Publicado 2023

Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA

por Matsubara, Nobuaki, de Bono, Johann, Olmos, David, Procopio, Giuseppe, Kawakami, Satoru, Ürün, Yüksel, van Alphen, Robbert, Flechon, Aude, Carducci, Michael A., Choi, Young Deuk, Hotte, Sebastien J., Korbenfeld, Ernesto, Kramer, Gero, Agarwal, Neeraj, Chi, Kim N., Dearden, Simon, Gresty, Christopher, Kang, Jinyu, Poehlein, Christian, Harrington, Elizabeth A., Hussain, Maha
Publicado 2023

Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study

por Benatar, Michael, Wuu, Joanne, Andersen, Peter M., Bucelli, Robert C., Andrews, Jinsy A., Otto, Markus, Farahany, Nita A., Harrington, Elizabeth A., Chen, Weiping, Mitchell, Adele A., Ferguson, Toby, Chew, Sheena, Gedney, Liz, Oakley, Sue, Heo, Jeong, Chary, Sowmya, Fanning, Laura, Graham, Danielle, Sun, Peng, Liu, Yingying, Wong, Janice, Fradette, Stephanie
Publicado 2022

Correction to: Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study

por Benatar, Michael, Wuu, Joanne, Andersen, Peter M., Bucelli, Robert C., Andrews, Jinsy A., Otto, Markus, Farahany, Nita A., Harrington, Elizabeth A., Chen, Weiping, Mitchell, Adele A., Ferguson, Toby, Chew, Sheena, Gedney, Liz, Oakley, Sue, Heo, Jeong, Chary, Sowmya, Fanning, Laura, Graham, Danielle, Sun, Peng, Liu, Yingying, Wong, Janice, Fradette, Stephanie
Publicado 2022

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

por Jones, Gemma N., Rooney, Claire, Griffin, Nicola, Roudier, Martine, Young, Lucy A., Garcia-Trinidad, Antonio, Hughes, Gareth D., Whiteaker, Jeffrey R., Wilson, Zena, Odedra, Rajesh, Zhao, Lei, Ivey, Richard G., Howat, William J., Harrington, Elizabeth A., Barrett, J. Carl, Ramos-Montoya, Antonio, Lau, Alan, Paulovich, Amanda G., Cadogan, Elaine B., Pierce, Andrew J.
Publicado 2018

Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response

por Willis, Sophie E., Winkler, Claudia, Roudier, Martine P., Baird, Tarrion, Marco-Casanova, Paola, Jones, Emma V., Rowe, Philip, Rodriguez-Canales, Jaime, Angell, Helen K., Ng, Felicia S. L., Waring, Paul M., Hodgson, Darren, Ledermann, Jonathan A., Weberpals, Johanne I., Dean, Emma, Harrington, Elizabeth A., Barrett, J. Carl, Pierce, Andrew J., Leo, Elisabetta, Jones, Gemma N.
Publicado 2021

1-(13)C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA)

por Manoli, Irini, Pass, Alexandra R., Harrington, Elizabeth A., Sloan, Jennifer L., Gagné, Jack, McCoy, Samantha, Bell, Sarah L., Hattenbach, Jacob D., Leitner, Brooks P., Duckworth, Courtney J., Fletcher, Laura A., Cassimatis, Thomas M., Galarreta, Carolina I., Thurm, Audrey, Snow, Joseph, Van Ryzin, Carol, Ferry, Susan, Mew, Nicholas Ah, Shchelochkov, Oleg A., Chen, Kong Y., Venditti, Charles P.
Publicado 2021

Correction to: 1-(13)C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA)

por Manoli, Irini, Pass, Alexandra R., Harrington, Elizabeth A., Sloan, Jennifer L., Gagné, Jack, McCoy, Samantha, Bell, Sarah L., Hattenbach, Jacob D., Leitner, Brooks P., Duckworth, Courtney J., Fletcher, Laura A., Cassimatis, Thomas M., Galarreta, Carolina I., Thurm, Audrey, Snow, Joseph, Van Ryzin, Carol, Ferry, Susan, Mew, Nicholas Ah, Shchelochkov, Oleg A., Chen, Kong Y., Venditti, Charles P.
Publicado 2021

Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition

por Whiteaker, Jeffrey R., Wang, Tao, Zhao, Lei, Schoenherr, Regine M., Kennedy, Jacob J., Voytovich, Ulianna, Ivey, Richard G., Huang, Dongqing, Lin, Chenwei, Colantonio, Simona, Caceres, Tessa W., Roberts, Rhonda R., Knotts, Joseph G., Kaczmarczyk, Jan A., Blonder, Josip, Reading, Joshua J., Richardson, Christopher W., Hewitt, Stephen M., Garcia-Buntley, Sandra S., Bocik, William, Hiltke, Tara, Rodriguez, Henry, Harrington, Elizabeth A., Barrett, J. Carl, Lombardi, Benedetta, Marco-Casanova, Paola, Pierce, Andrew J., Paulovich, Amanda G.
Publicado 2021

Serial monitoring of genomic alterations in circulating tumor cells of ER‐positive/HER2‐negative advanced breast cancer: feasibility of precision oncology biomarker detection

por Cani, Andi K., Dolce, Emily M., Darga, Elizabeth P., Hu, Kevin, Liu, Chia‐Jen, Pierce, Jackie, Bradbury, Kieran, Kilgour, Elaine, Aung, Kimberly, Schiavon, Gaia, Carroll, Danielle, Carr, T. Hedley, Klinowska, Teresa, Lindemann, Justin, Marshall, Gayle, Rowlands, Vicky, Harrington, Elizabeth A., Barrett, J. Carl, Sathiyayogan, Nitharsan, Morrow, Christopher, Sero, Valeria, Armstrong, Anne C., Baird, Richard, Hamilton, Erika, Im, Seock‐Ah, Jhaveri, Komal, Patel, Manish R., Dive, Caroline, Tomlins, Scott A., Udager, Aaron M., Hayes, Daniel F., Paoletti, Costanza
Publicado 2021