Identification of cancer genes that are independent of dominant proliferation and lineage programs

por Selfors, Laura M., Stover, Daniel G., Harris, Isaac S., Brugge, Joan S., Coloff, Jonathan L.
Publicado 2017

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

por Raymonda, Matthew H., Rodríguez-Sánchez, Irene, Schafer, Xenia L., Smorodintsev-Schiller, Leonid, Harris, Isaac S., Munger, Joshua
Publicado 2023

Reducing Slip Risk: A Feasibility Study of Gait Training with Semi-Real-Time Feedback of Foot–Floor Contact Angle

por Ma, Christina Zong-Hao, Bao, Tian, DiCesare, Christopher A., Harris, Isaac, Chambers, April, Shull, Peter B., Zheng, Yong-Ping, Cham, Rakie, Sienko, Kathleen H.
Publicado 2022

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3

por Lee, Jaewon J., van de Ven, Robert A. H., Zaganjor, Elma, Ng, Mei Rosa, Barakat, Amey, Demmers, Joris J. P. G., Finley, Lydia W. S., Gonzalez Herrera, Karina N., Hung, Yin Pun, Harris, Isaac S., Jeong, Seung Min, Danuser, Gaudenz, McAllister, Sandra S., Haigis, Marcia C.
Publicado 2018

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy

por Rawat, Vipin, DeLear, Patrick, Prashanth, Prarthana, Ozgurses, Mete Emir, Tebeje, Anteneh, Burns, Philippa A., Conger, Kelly O., Solís, Christopher, Hasnain, Yasir, Novikova, Anna, Endress, Jennifer E., González-Sánchez, Paloma, Dong, Wentao, Stephanopoulos, Greg, DeNicola, Gina M., Harris, Isaac S., Sept, David, Mason, Frank M., Coloff, Jonathan L.
Publicado 2023

DDRE-29. DE NOVO PYRIMIDINE SYNTHESIS IS A TARGETABLE VULNERABILITY IN IDH-MUTANT GLIOMA

por Shi, Diana D, Wang, Adam C, Levitt, Michael M, Endress, Jennifer E, Xu, Min, Gao, Wenhua, Khanal, Januka, Bonal, Dennis, Kornblum, Harley I, Nguyen, Quang-De, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Cahill, Daniel P, Ligon, Keith L, Abdullah, Kalil G, Harris, Isaac S, Kaelin, William G, McBrayer, Samuel K
Publicado 2021

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

por Gorrini, Chiara, Baniasadi, Pegah S., Harris, Isaac S., Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A., Wakeham, Andrew, Molyneux, Sam D., Martin, Bernard, Bouwman, Peter, Cescon, David W., Elia, Andrew J., Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K., Khokha, Rama, Jonkers, Jos, Mak, Tak W., Gauthier, Mona L.
Publicado 2013

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

por Bonetti, Lynn, Horkova, Veronika, Longworth, Joseph, Guerra, Luana, Kurniawan, Henry, Franchina, Davide G., Soriano-Baguet, Leticia, Grusdat, Melanie, Spath, Sabine, Koncina, Eric, Ewen, Anouk, Binsfeld, Carole, Verschueren, Charlène, Gérardy, Jean-Jacques, Kobayashi, Takumi, Dostert, Catherine, Farinelle, Sophie, Härm, Janika, Chen, Ying, Harris, Isaac S., Lang, Philipp A., Vasiliou, Vasilis, Waisman, Ari, Letellier, Elisabeth, Becher, Burkhard, Mittelbronn, Michel, Brenner, Dirk
Publicado 2023

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

por Zee, Barry M., Poels, Kamrine E., Yao, Cong-Hui, Kawabata, Kimihito C., Wu, Gongwei, Duy, Cihangir, Jacobus, William D., Senior, Elizabeth, Endress, Jennifer E., Jambhekar, Ashwini, Lovitch, Scott B., Ma, Jiexian, Dhall, Abhinav, Harris, Isaac S., Blanco, M. Andres, Sykes, David B., Licht, Jonathan D., Weinstock, David M., Melnick, Ari, Haigis, Marcia C., Michor, Franziska, Shi, Yang
Publicado 2021

Targeting oncoproteins with a positive selection assay for protein degraders

por Koduri, Vidyasagar, Duplaquet, Leslie, Lampson, Benjamin L., Wang, Adam C., Sabet, Amin H., Ishoey, Mette, Paulk, Joshiawa, Teng, Mingxing, Harris, Isaac S., Endress, Jennifer E., Liu, Xiaoxi, Dasilva, Ethan, Paulo, Joao A., Briggs, Kimberly J., Doench, John G., Ott, Christopher J., Zhang, Tinghu, Donovan, Katherine A., Fischer, Eric S., Gygi, Steven P., Gray, Nathanael S., Bradner, James, Medin, Jeffrey A., Buhrlage, Sara J., Oser, Matthew G., Kaelin, William G.
Publicado 2021

Glutathione supports lipid abundance in vivo

por Asantewaa, Gloria, Tuttle, Emily T., Ward, Nathan P., Kang, Yun Pyo, Kim, Yumi, Kavanagh, Madeline E., Girnius, Nomeda, Chen, Ying, Duncan, Renae, Rodriguez, Katherine, Hecht, Fabio, Zocchi, Marco, Smorodintsev-Schiller, Leonid, Scales, TashJaé Q., Taylor, Kira, Alimohammadi, Fatemeh, Sechrist, Zachary R, Agostini-Vulaj, Diana, Schafer, Xenia L., Chang, Hayley, Smith, Zachary, O’Connor, Thomas N., Whelan, Sarah, Selfors, Laura M., Crowdis, Jett, Gray, G. Kenneth, Bronson, Roderick T., Brenner, Dirk, Rufini, Alessandro, Dirksen, Robert T., Hezel, Aram F., Huber, Aaron R., Munger, Josh, Cravatt, Benjamin F., Vasiliou, Vasilis, Cole, Calvin L, DeNicola, Gina M., Harris, Isaac S.
Publicado 2023

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

por Shi, Diana D., Savani, Milan R., Levitt, Michael M., Wang, Adam C., Endress, Jennifer E., Bird, Cylaina E., Buehler, Joseph, Stopka, Sylwia A., Regan, Michael S., Lin, Yu-Fen, Puliyappadamba, Vinesh T., Gao, Wenhua, Khanal, Januka, Evans, Laura, Lee, Joyce H., Guo, Lei, Xiao, Yi, Xu, Min, Huang, Bofu, Jennings, Rebecca B., Bonal, Dennis M., Martin-Sandoval, Misty S., Dang, Tammie, Gattie, Lauren C., Cameron, Amy B., Lee, Sungwoo, Asara, John M., Kornblum, Harley I., Mak, Tak W., Looper, Ryan E., Nguyen, Quang-De, Signoretti, Sabina, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Lehrman, Mark A., Zacharias, Lauren G., Mathews, Thomas P., Losman, Julie-Aurore, Richardson, Timothy E., Cahill, Daniel P., DeBerardinis, Ralph J., Ligon, Keith L., Xu, Lin, Ly, Peter, Agar, Nathalie Y.R., Abdullah, Kalil G., Harris, Isaac S., Kaelin, William G., McBrayer, Samuel K.
Publicado 2022

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

por Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Katiuscia, Blagosklonny, Mikhail V., Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chandel, Navdeep S., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Cohen, Gerald M., Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Dawson, Ted M., Dawson, Valina L., De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M., Dixon, Scott J., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. Marie, Harris, Isaac S., Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J., Juin, Philippe P., Kaiser, William J., Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Knight, Richard A., Kumar, Sharad, Lee, Sam W., Lemasters, John J., Levine, Beth, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Lowe, Scott W., Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Muñoz-Pinedo, Cristina, Nagata, Shigekazu, Nuñez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro, Pinton, Paolo, Prehn, Jochen H.M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rehm, Markus, Rizzuto, Rosario, Rodrigues, Cecilia M.P., Rubinsztein, David C., Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas, Szabadkai, Gyorgy, Tait, Stephen W.G., Tang, Daolin, Tavernarakis, Nektarios, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris, Vanden Berghe, Tom, Vandenabeele, Peter, Vander Heiden, Matthew G., Villunger, Andreas, Virgin, Herbert W., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido
Publicado 2018