Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 i...

por Wang, Aiying, Dorso, Charles, Kopcho, Lisa, Locke, Gregory, Langish, Robert, Harstad, Eric, Shipkova, Petia, Marcinkeviciene, Jovita, Hamann, Lawrence, Kirby, Mark S
Publicado 2012

Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species

por Hardwick, Rhiannon N, Brassil, Patrick, Badagnani, Ilaria, Perkins, Kimberly, Obedencio, Glenmar P, Kim, Andrea S, Conner, Michael W, Bourdet, David L, Harstad, Eric B
Publicado 2022