Intragenic Distribution of IS6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance

por Antoine, Rudy, Gaudin, Cyril, Hartkoorn, Ruben C.
Publicado 2021

Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides

por Ollivier, Nathalie, Toupy, Thomas, Hartkoorn, Ruben C., Desmet, Rémi, Monbaliu, Jean-Christophe M., Melnyk, Oleg
Publicado 2018

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria

por Compagne, Nina, Vieira Da Cruz, Anais, Müller, Reinke T., Hartkoorn, Ruben C., Flipo, Marion, Pos, Klaas M.
Publicado 2023

Characterization of pyridylpiperazine-based efflux pump inhibitors for Acinetobacter baumannii

por Jiménez-Castellanos, Juan-Carlos, Pradel, Elizabeth, Compagne, Nina, Vieira Da Cruz, Anais, Flipo, Marion, Hartkoorn, Ruben C
Publicado 2023

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

por Hartkoorn, Ruben C, Sala, Claudia, Neres, João, Pojer, Florence, Magnet, Sophie, Mukherjee, Raju, Uplekar, Swapna, Boy-Röttger, Stefanie, Altmann, Karl-Heinz, Cole, Stewart T
Publicado 2012

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

por Dogga, Sunil Kumar, Mukherjee, Budhaditya, Jacot, Damien, Kockmann, Tobias, Molino, Luca, Hammoudi, Pierre-Mehdi, Hartkoorn, Ruben C, Hehl, Adrian B, Soldati-Favre, Dominique
Publicado 2017

A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling

por Caradec, Thibault, Anoz-Carbonell, Ernesto, Petrov, Ravil, Billamboz, Muriel, Antraygues, Kevin, Cantrelle, Francois-Xavier, Boll, Emmanuelle, Beury, Delphine, Hot, David, Drobecq, Herve, Trivelli, Xavier, Hartkoorn, Ruben C.
Publicado 2023

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

por Temesszentandrási-Ambrus, Csilla, Tóth, Szilárd, Verma, Rinkee, Bánhegyi, Péter, Szabadkai, István, Baska, Ferenc, Szántai-Kis, Csaba, Hartkoorn, Ruben C., Lingerfelt, Mary A., Sarkadi, Balázs, Szakács, Gergely, Őrfi, László, Nagaraja, Valakunja, Ekins, Sean, Telbisz, Ágnes
Publicado 2018

Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases

por Dam, Sushovan, Tangara, Salia, Hamela, Claire, Hattabi, Theo, Faïon, Léo, Carre, Paul, Antoine, Rudy, Herledan, Adrien, Leroux, Florence, Piveteau, Catherine, Eveque, Maxime, Flipo, Marion, Deprez, Benoit, Kremer, Laurent, Willand, Nicolas, Villemagne, Baptiste, Hartkoorn, Ruben C.
Publicado 2022

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

por Makarov, Vadim, Lechartier, Benoit, Zhang, Ming, Neres, João, Sar, Astrid M, Raadsen, Susanne A, Hartkoorn, Ruben C, Ryabova, Olga B, Vocat, Anthony, Decosterd, Laurent A, Widmer, Nicolas, Buclin, Thierry, Bitter, Wilbert, Andries, Koen, Pojer, Florence, Dyson, Paul J, Cole, Stewart T
Publicado 2014

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

por Singh, Vinayak, Donini, Stefano, Pacitto, Angela, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Keri, Gyorgy, Ascher, David B., Mondésert, Guillaume, Vocat, Anthony, Lupien, Andréanne, Sommer, Raphael, Vermet, Hélène, Lagrange, Sophie, Buechler, Joe, Warner, Digby F., McKinney, John D., Pato, Janos, Cole, Stewart T., Blundell, Tom L., Rizzi, Menico, Mizrahi, Valerie
Publicado 2016

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

por Plé, Coline, Tam, Heng-Keat, Vieira Da Cruz, Anais, Compagne, Nina, Jiménez-Castellanos, Juan-Carlos, Müller, Reinke T., Pradel, Elizabeth, Foong, Wuen Ee, Malloci, Giuliano, Ballée, Alexia, Kirchner, Moritz A., Moshfegh, Parisa, Herledan, Adrien, Herrmann, Andrea, Deprez, Benoit, Willand, Nicolas, Vargiu, Attilio Vittorio, Pos, Klaas M., Flipo, Marion, Hartkoorn, Ruben C.
Publicado 2022

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

por Mori, Giorgia, Chiarelli, Laurent R., Esposito, Marta, Makarov, Vadim, Bellinzoni, Marco, Hartkoorn, Ruben C., Degiacomi, Giulia, Boldrin, Francesca, Ekins, Sean, de Jesus Lopes Ribeiro, Ana Luisa, Marino, Leonardo B., Centárová, Ivana, Svetlíková, Zuzana, Blaško, Jaroslav, Kazakova, Elena, Lepioshkin, Alexander, Barilone, Nathalie, Zanoni, Giuseppe, Porta, Alessio, Fondi, Marco, Fani, Renato, Baulard, Alain R., Mikušová, Katarína, Alzari, Pedro M., Manganelli, Riccardo, de Carvalho, Luiz Pedro S., Riccardi, Giovanna, Cole, Stewart T., Pasca, Maria Rosalia
Publicado 2015