A 96-well DNase I footprinting screen for drug–DNA interactions

por Ellis, Tom, Evans, David A., Martin, Christopher R. H., Hartley, John A.
Publicado 2007

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

por Tomas, Alejandra, Vaughan, Simon O., Burgoyne, Thomas, Sorkin, Alexander, Hartley, John A., Hochhauser, Daniel, Futter, Clare E.
Publicado 2015

Atomic force microscopy—A tool for structural and translational DNA research

por Main, Kavit H. S., Provan, James I., Haynes, Philip J., Wells, Geoffrey, Hartley, John A., Pyne, Alice L. B.
Publicado 2021

NF-Y activates genes of metabolic pathways altered in cancer cells

por Benatti, Paolo, Chiaramonte, Maria Luisa, Lorenzo, Mariangela, Hartley, John A., Hochhauser, Daniel, Gnesutta, Nerina, Mantovani, Roberto, Imbriano, Carol, Dolfini, Diletta
Publicado 2015

Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer

por Santoro, Valeria, Jia, Ruochen, Thompson, Hannah, Nijhuis, Anke, Jeffery, Rosemary, Kiakos, Konstantinos, Silver, Andrew R., Hartley, John A., Hochhauser, Daniel
Publicado 2015

hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors

por Gundogdu, Ramazan, Erdogan, M. Kadir, Ditsiou, Angeliki, Spanswick, Victoria, Garcia-Gomez, Juan Jose, Hartley, John A., Esashi, Fumiko, Hergovich, Alexander, Gomez, Valenti
Publicado 2021

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]be...

por Clingen, Peter H., De Silva, Inusha U., McHugh, Peter J., Ghadessy, Farid J, Tilby, Michael J., Thurston, David E., Hartley, John A.
Publicado 2005

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

por Cook, Rebecca, Zoumpoulidou, Georgia, Luczynski, Maciej T., Rieger, Simone, Moquet, Jayne, Spanswick, Victoria J., Hartley, John A., Rothkamm, Kai, Huang, Paul H., Mittnacht, Sibylle
Publicado 2015

Expression of somatostatin receptors 2 and 5 in circulating tumour cells from patients with neuroendocrine tumours

por Childs, Alexa, Vesely, Clare, Ensell, Leah, Lowe, Helen, Luong, Tu Vinh, Caplin, Martyn E, Toumpanakis, Christos, Thirlwell, Christina, Hartley, John A, Meyer, Tim
Publicado 2016

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples

por Spanswick, Victoria J, Lowe, Helen L, Newton, Claire, Bingham, John P, Bagnobianchi, Alessia, Kiakos, Konstantinos, Craddock, Charles, Ledermann, Jonathan A, Hochhauser, Daniel, Hartley, John A
Publicado 2012

Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers

por Zammarchi, Francesca, Havenith, Karin EG., Chivers, Simon, Hogg, Paul, Bertelli, Francois, Tyrer, Peter, Janghra, Narinder, Reinert, Halla W., Hartley, John A., van Berkel, Patrick H.
Publicado 2022

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases

por Sengerová, Blanka, Allerston, Charles K., Abu, Mika, Lee, Sook Y., Hartley, Janet, Kiakos, Konstantinos, Schofield, Christopher J., Hartley, John A., Gileadi, Opher, McHugh, Peter J.
Publicado 2012

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

por Ip, Laura R. H., Poulogiannis, George, Viciano, Felipe Cia, Sasaki, Junko, Kofuji, Satoshi, Spanswick, Victoria J., Hochhauser, Daniel, Hartley, John A., Sasaki, Takehiko, Gewinner, Christina A.
Publicado 2015

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

por Mellinas-Gomez, Maria, Spanswick, Victoria J., Paredes-Moscosso, Solange R., Robson, Matthew, Pedley, R. Barbara, Thurston, David E., Baines, Stephen J., Stell, Anneliese, Hartley, John A.
Publicado 2015

MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

por Vena, Francesca, Jia, Ruochen, Esfandiari, Arman, Garcia-Gomez, Juan J., Rodriguez-Justo, Manuel, Ma, Jianguo, Syed, Sakeena, Crowley, Lindsey, Elenbaas, Brian, Goodstal, Samantha, Hartley, John A., Hochhauser, Daniel
Publicado 2018

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation

por Jones, Sylwia, King, Peter J., Antonescu, Costin N., Sugiyama, Michael G., Bhamra, Amandeep, Surinova, Silvia, Angelopoulos, Nicos, Kragh, Michael, Pedersen, Mikkel W., Hartley, John A., Futter, Clare E., Hochhauser, Daniel
Publicado 2020

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

por Ohnmacht, Stephan A, Marchetti, Chiara, Gunaratnam, Mekala, Besser, Rachael J, Haider, Shozeb M, Di Vita, Gloria, Lowe, Helen L, Mellinas-Gomez, Maria, Diocou, Seckou, Robson, Mathew, Šponer, Jiri, Islam, Barira, Barbara Pedley, R, Hartley, John A, Neidle, Stephen
Publicado 2015

Whole-genome sequencing of single circulating tumor cells from neuroendocrine neoplasms

por Childs, Alexa, Steele, Christopher D, Vesely, Clare, Rizzo, Francesca M, Ensell, Leah, Lowe, Helen, Dhami, Pawan, Vaikkinen, Heli, Luong, Tu Vinh, Conde, Lucia, Herrero, Javier, Caplin, Martyn, Toumpanakis, Christos, Thirlwell, Christina, Hartley, John A, Pillay, Nischalan, Meyer, Tim
Publicado 2021

Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus

por Moore, Kate M., Desai, Ami, Delgado, Bea de Luxán, Trabulo, Sara Maria David, Reader, Claire, Brown, Nicholas F., Murray, Elizabeth R., Brentnall, Adam, Howard, Philip, Masterson, Luke, Zammarchi, Francesca, Hartley, John A., van Berkel, Patrick H., Marshall, John F.
Publicado 2020

Circulating tumour cells and their association with bone metastases in patients with neuroendocrine tumours

por Rizzo, Francesca M., Vesely, Clare, Childs, Alexa, Marafioti, Teresa, Khan, Mohid S., Mandair, Dalvinder, Cives, Mauro, Ensell, Leah, Lowe, Helen, Akarca, Ayse U., Luong, TuVinh, Caplin, Martyn, Toumpanakis, Christos, Krell, Daniel, Thirlwell, Christina, Silvestris, Franco, Hartley, John A., Meyer, Tim
Publicado 2019