Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

por Planelles-Herrero, Vicente J., Hartman, James J., Robert-Paganin, Julien, Malik, Fady I., Houdusse, Anne
Publicado 2017

Supraphysiological levels of GDF11 induce striated muscle atrophy

por Hammers, David W, Merscham‐Banda, Melissa, Hsiao, Jennifer Ying, Engst, Stefan, Hartman, James J, Sweeney, H Lee
Publicado 2017

Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity

por Singh, Rohit R., Slater, Rebecca E., Wang, Jinghong, Wang, Chen, Guo, Qi, Motani, Alykhan S., Hartman, James J., Sadayappan, Sakthivel, Ason, Brandon L.
Publicado 2022

The Ca(2+) sensitizer CK‐2066260 increases myofibrillar Ca(2+) sensitivity and submaximal force selectively in fast skeletal muscle

por Hwee, Darren T., Cheng, Arthur J., Hartman, James J., Hinken, Aaron C., Lee, Ken, Durham, Nickie, Russell, Alan J., Malik, Fady I., Westerblad, Håkan, Jasper, Jeffrey R.
Publicado 2017

Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

por He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan S., Nguyen, Kathy K., Liu, Qingxiang, Slater, Rebecca, Rock, Brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J., Malik, Fady I., Reagan, Jeff D., Luptak, Ivan
Publicado 2021

Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery

por Huang, Guanyi, Bisaria, Anjali, Wakefield, Devin L., Yamawaki, Tracy M., Luo, Xin, Zhang, Jingli A., Vigneault, Patrick, Wang, Jinghong, Reagan, Jeffrey D., Oliverio, Oliver, Zhou, Hong, Li, Chi-Ming, Vila, Olaia F., Wang, Songli, Malik, Fady I., Hartman, James J., Hale, Christopher M.
Publicado 2022

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

por Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Publicado 2012