Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

por Negri, Matthias, Recanatini, Maurizio, Hartmann, Rolf W.
Publicado 2010

3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2

por Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Publicado 2012

Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer

por Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Publicado 2013

Crystal structure of 4-methyl­sulfanyl-2-(2H-tetra­zol-2-yl)pyrimidine

por Thomann, Andreas, Huch, Volker, Hartmann, Rolf W.
Publicado 2015

Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17β-Hydroxysteroid Dehydrogenase Type...

por Perspicace, Enrico, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.
Publicado 2013

Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa

por Schaadt, Nadine S, Steinbach, Anke, Hartmann, Rolf W, Helms, Volkhard
Publicado 2013

Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

por Akram, Muhammad, Waratchareeyakul, Watcharee, Haupenthal, Joerg, Hartmann, Rolf W., Schuster, Daniela
Publicado 2017

Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction

por Holzer, Marcel, Ziegler, Sigrid, Kronenberger, Bernd, Klein, Christian D, Hartmann, Rolf W
Publicado 2008

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

por Steinbach, Anke, Maurer, Christine K, Weidel, Elisabeth, Henn, Claudia, Brengel, Christian, Hartmann, Rolf W, Negri, Matthias
Publicado 2013

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

por Allegretta, Giuseppe, Maurer, Christine K., Eberhard, Jens, Maura, Damien, Hartmann, Rolf W., Rahme, Laurence, Empting, Martin
Publicado 2017

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors

por Schmitt, Christian, Kail, Dagmar, Mariano, Marica, Empting, Martin, Weber, Nadja, Paul, Tamara, Hartmann, Rolf W., Engel, Matthias
Publicado 2014

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

por Gargano, Emanuele M., Allegretta, Giuseppe, Perspicace, Enrico, Carotti, Angelo, Van Koppen, Chris, Frotscher, Martin, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.
Publicado 2015

Identification of Terfenadine as an Inhibitor of HumanCD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

por Holzer, Marcel, Ziegler, Sigrid, Albrecht, Beatrice, Kronenberger, Bernd, Kaul, Artur, Bartenschlager, Ralf, Kattner, Lars, Klein, Christian D., Hartmann, Rolf W.
Publicado 2008

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

por Castoldi, Arianna, Empting, Martin, De Rossi, Chiara, Mayr, Karsten, Dersch, Petra, Hartmann, Rolf, Müller, Rolf, Gordon, Sarah, Lehr, Claus-Michael
Publicado 2018

Structure‐Activity Relationship and Mode‐Of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1H‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors

por Walter, Isabell, Adam, Sebastian, Gentilini, Maria Virginia, Kany, Andreas M., Brengel, Christian, Thomann, Andreas, Sparwasser, Tim, Köhnke, Jesko, Hartmann, Rolf W.
Publicado 2021

Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)

por Voos, Katrin, Schönauer, Esther, Alhayek, Alaa, Haupenthal, Jörg, Andreas, Anastasia, Müller, Rolf, Hartmann, Rolf W., Brandstetter, Hans, Hirsch, Anna K. H., Ducho, Christian
Publicado 2021

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

por Schönauer, Esther, Kany, Andreas M., Haupenthal, Jörg, Hüsecken, Kristina, Hoppe, Isabel J., Voos, Katrin, Yahiaoui, Samir, Elsässer, Brigitta, Ducho, Christian, Brandstetter, Hans, Hartmann, Rolf W.
Publicado 2017

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics

por Elgaher, Walid A. M., Hamed, Mostafa M., Baumann, Sascha, Herrmann, Jennifer, Siebenbürger, Lorenz, Krull, Jana, Cirnski, Katarina, Kirschning, Andreas, Brönstrup, Mark, Müller, Rolf, Hartmann, Rolf W.
Publicado 2020

Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

por Kaya, Cansu, Walter, Isabell, Yahiaoui, Samir, Sikandar, Asfandyar, Alhayek, Alaa, Konstantinović, Jelena, Kany, Andreas M., Haupenthal, Jörg, Köhnke, Jesko, Hartmann, Rolf W., Hirsch, Anna K. H.
Publicado 2021

Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure–Activity Relationship Study of C-Glycosidic LecB Inhibitors

por Sommer, Roman, Rox, Katharina, Wagner, Stefanie, Hauck, Dirk, Henrikus, Sarah S., Newsad, Shelby, Arnold, Tatjana, Ryckmans, Thomas, Brönstrup, Mark, Imberty, Anne, Varrot, Annabelle, Hartmann, Rolf W., Titz, Alexander
Publicado 2019