Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

por Dart, Melanie L., Machleidt, Thomas, Jost, Emily, Schwinn, Marie K., Robers, Matthew B., Shi, Ce, Kirkland, Thomas A., Killoran, Michael P., Wilkinson, Jennifer M., Hartnett, James R., Zimmerman, Kristopher, Wood, Keith V.
Publicado 2018

Target engagement and drug residence time can be observed in living cells with BRET

por Robers, Matthew B., Dart, Melanie L., Woodroofe, Carolyn C., Zimprich, Chad A., Kirkland, Thomas A., Machleidt, Thomas, Kupcho, Kevin R., Levin, Sergiy, Hartnett, James R., Zimmerman, Kristopher, Niles, Andrew L., Ohana, Rachel Friedman, Daniels, Danette L., Slater, Michael, Wood, Monika G., Cong, Mei, Cheng, Yi-Qiang, Wood, Keith V.
Publicado 2015

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

por Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Hartnett, James R., Ingold, Morgan R., Zimmerman, Kristopher, Machleidt, Thomas, Kirkland, Thomas A., Huwiler, Kristin G., Ohana, Rachel Friedman, Slater, Michael, Otto, Paul, Cong, Mei, Wells, Carrow I., Berger, Benedict-Tilman, Hanke, Thomas, Glas, Carina, Ding, Ke, Drewry, David H., Huber, Kilian V.M., Willson, Timothy M., Knapp, Stefan, Müller, Susanne, Meisenheimer, Poncho L., Fan, Frank, Wood, Keith V., Robers, Matthew B.
Publicado 2018