Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors

por Nogueira, Diogo E. S., Rodrigues, Carlos A. V., Carvalho, Marta S., Miranda, Cláudia C., Hashimura, Yas, Jung, Sunghoon, Lee, Brian, Cabral, Joaquim M. S.
Publicado 2019

Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products

por Lee, Brian, Jung, Sunghoon, Hashimura, Yas, Lee, Maximilian, Borys, Breanna S., Dang, Tiffany, Kallos, Michael S., Rodrigues, Carlos A. V., Silva, Teresa P., Cabral, Joaquim M. S.
Publicado 2022

Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors

por Borys, Breanna S., Dang, Tiffany, So, Tania, Rohani, Leili, Revay, Tamas, Walsh, Tylor, Thompson, Madalynn, Argiropoulos, Bob, Rancourt, Derrick E., Jung, Sunghoon, Hashimura, Yas, Lee, Brian, Kallos, Michael S.
Publicado 2021

Characterization of the Aeration and Hydrodynamics in Vertical-Wheel(™) Bioreactors

por Neto, Pedro M., Nogueira, Diogo E. S., Hashimura, Yas, Jung, Sunghoon, Pedras, Bruno, Berberan-Santos, Mário N., Palmeira, Tiago, Lee, Brian, Cabral, Joaquim M. S., Geraldes, Vitor, Rodrigues, Carlos A. V.
Publicado 2022

Optimized serial expansion of human induced pluripotent stem cells using low‐density inoculation to generate clinically relevant quantities in vertical‐wheel bioreactors

por Borys, Breanna S., So, Tania, Colter, James, Dang, Tiffany, Roberts, Erin L., Revay, Tamas, Larijani, Leila, Krawetz, Roman, Lewis, Ian, Argiropoulos, Bob, Rancourt, Derrick E., Jung, Sunghoon, Hashimura, Yas, Lee, Brian, Kallos, Michael S.
Publicado 2020