How Single Amino Acid Substitutions Can Disrupt a Protein Hetero-Dimer Interface: Computational and Experimental Studies of the LigAB Dioxygenase from Sphingobium sp. Strain SYK-6

por Rafalowski, Angelika, Hassan, Bakar A., Lou, Kate, Nguyen, Minh Chau, Taylor, Erika A.
Publicado 2023

Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics

por Ramirez-Mondragon, Carlos A., Nguyen, Megin E., Milicaj, Jozafina, Hassan, Bakar A., Tucci, Frank J., Muthyala, Ramaiah, Gao, Jiali, Taylor, Erika A., Sham, Yuk Y.
Publicado 2021

Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action

por Milicaj, Jozafina, Hassan, Bakar A., Cote, Joy M., Ramirez-Mondragon, Carlos A., Jaunbocus, Nadiya, Rafalowski, Angelika, Patel, Kaelan R., Castro, Colleen D., Muthyala, Ramaiah, Sham, Yuk Y., Taylor, Erika A.
Publicado 2022

Structural and photophysical characterization of the small ultra-red fluorescent protein

por Maiti, Atanu, Buffalo, Cosmo Z., Saurabh, Saumya, Montecinos-Franjola, Felipe, Hachey, Justin S., Conlon, William J., Tran, Geraldine N., Hassan, Bakar, Walters, Kylie J., Drobizhev, Mikhail, Moerner, W. E., Ghosh, Partho, Matsuo, Hiroshi, Tsien, Roger Y., Lin, John Y., Rodriguez, Erik A.
Publicado 2023

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases

por Collins, Jason C., Magaziner, Samuel J., English, Maya, Hassan, Bakar, Chen, Xiang, Balanda, Nicholas, Anderson, Meghan, Lam, Athena, Fernandez-Pol, Sebastian, Kwong, Bernice, Greenberg, Peter L., Terrier, Benjamin, Likhite, Mary E., Kosmider, Olivier, Wang, Yan, Samara, Nadine L., Walters, Kylie J., Beck, David B., Werner, Achim
Publicado 2023