Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant

por Mimoto, Futa, Igawa, Tomoyuki, Kuramochi, Taichi, Katada, Hitoshi, Kadono, Shojiro, Kamikawa, Takayuki, Shida-Kawazoe, Meiri, Hattori, Kunihiro
Publicado 2013

Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

por Maeda, Atsuhiko, Iwayanagi, Yuki, Haraya, Kenta, Tachibana, Tatsuhiko, Nakamura, Genki, Nambu, Takeru, Esaki, Keiko, Hattori, Kunihiro, Igawa, Tomoyuki
Publicado 2017

Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity

por Sampei, Zenjiro, Igawa, Tomoyuki, Soeda, Tetsuhiro, Funaki, Miho, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Muto, Atsushi, Kojima, Tetsuo, Nakamura, Satoshi, Hattori, Kunihiro
Publicado 2014

Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies

por Suzuki, Kei, Tsunoda, Hiroyuki, Omiya, Ryusuke, Matoba, Kyoko, Baba, Takeshi, Suzuki, Sachiyo, Segawa, Hiroaki, Kumanogoh, Atsushi, Iwasaki, Kenji, Hattori, Kunihiro, Takagi, Junichi
Publicado 2016

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

por Kitazawa, Takehisa, Esaki, Keiko, Tachibana, Tatsuhiko, Ishii, Shinya, Soeda, Tetsuhiro, Muto, Atsushi, Kawabe, Yoshiki, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Nogami, Keiji, Shima, Midori, Hattori, Kunihiro
Publicado 2017

Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

por Igawa, Tomoyuki, Maeda, Atsuhiko, Haraya, Kenta, Tachibana, Tatsuhiko, Iwayanagi, Yuki, Mimoto, Futa, Higuchi, Yoshinobu, Ishii, Shinya, Tamba, Shigero, Hironiwa, Naoka, Nagano, Kozue, Wakabayashi, Tetsuya, Tsunoda, Hiroyuki, Hattori, Kunihiro
Publicado 2013

Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor

por Ueda, Otoya, Tateishi, Hiromi, Higuchi, Yoshinobu, Fujii, Etsuko, Kato, Atsuhiko, Kawase, Yosuke, Wada, Naoko A., Tachibe, Takanori, Kakefuda, Mami, Goto, Chisato, Kawaharada, Makoto, Shimaoka, Shin, Hattori, Kunihiro, Jishage, Kou-ichi
Publicado 2013

Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis

por Nishide, Masayuki, Nishimura, Kei, Matsushita, Hiroaki, Edahiro, Ryuya, Inukai, Sachi, Shimagami, Hiroshi, Kawada, Shoji, Kato, Yasuhiro, Kawasaki, Takahiro, Tsujimoto, Kohei, Kamon, Hokuto, Omiya, Ryusuke, Okada, Yukinori, Hattori, Kunihiro, Narazaki, Masashi, Kumanogoh, Atsushi
Publicado 2023

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

por Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Publicado 2018

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

por Hori, Yuji, Ohmine, Ken, Katada, Hitoshi, Noguchi, Yuki, Sato, Kazuki, Nambu, Takeru, Adeline, Lam Runyi, Wan, Gan Siok, Haraya, Kenta, Ozeki, Kazuhisa, Nanami, Masahiko, Tachibana, Tatsuhiko, Sampei, Zenjiro, Kuramochi, Taichi, Nezu, Junichi, Hattori, Kunihiro, Igawa, Tomoyuki
Publicado 2022

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

por Sampei, Zenjiro, Igawa, Tomoyuki, Soeda, Tetsuhiro, Okuyama-Nishida, Yukiko, Moriyama, Chifumi, Wakabayashi, Tetsuya, Tanaka, Eriko, Muto, Atsushi, Kojima, Tetsuo, Kitazawa, Takehisa, Yoshihashi, Kazutaka, Harada, Aya, Funaki, Miho, Haraya, Kenta, Tachibana, Tatsuhiko, Suzuki, Sachiyo, Esaki, Keiko, Nabuchi, Yoshiaki, Hattori, Kunihiro
Publicado 2013

Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics

por Ueda, Otoya, Wada, Naoko A., Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi
Publicado 2017

Corrigendum: Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics

por Ueda, Otoya, Wada, Naoko A., Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi
Publicado 2018

Novel myostatin-specific antibody enhances muscle strength in muscle disease models

por Muramatsu, Hiroyasu, Kuramochi, Taichi, Katada, Hitoshi, Ueyama, Atsunori, Ruike, Yoshinao, Ohmine, Ken, Shida-Kawazoe, Meiri, Miyano-Nishizawa, Rie, Shimizu, Yuichiro, Okuda, Momoko, Hori, Yuji, Hayashi, Madoka, Haraya, Kenta, Ban, Nobuhiro, Nonaka, Tatsuya, Honda, Masaki, Kitamura, Hidetomo, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki, Kawabe, Yoshiki, Nezu, Junichi
Publicado 2021

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

por Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Publicado 2017