The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

por Camberlein, Virgyl, Jézéquel, Gwenaëlle, Haupenthal, Jörg, Hirsch, Anna K. H.
Publicado 2022

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

por Bousis, Spyridon, Winkler, Steffen, Haupenthal, Jörg, Fulco, Francesco, Diamanti, Eleonora, Hirsch, Anna K. H.
Publicado 2022

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

por Elangovan, Saravanakumar, Afanasenko, Anastasiia, Haupenthal, Jörg, Sun, Zhuohua, Liu, Yongzhuang, Hirsch, Anna K. H., Barta, Katalin
Publicado 2019

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

por Kiefer, Alexander F., Bousis, Spyridon, Hamed, Mostafa M., Diamanti, Eleonora, Haupenthal, Jörg, Hirsch, Anna K.H.
Publicado 2022

Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

por Drost, Menka, Diamanti, Eleonora, Fuhrmann, Kathrin, Goes, Adriely, Shams, Atanaz, Haupenthal, Jörg, Koch, Marcus, Hirsch, Anna K. H., Fuhrmann, Gregor
Publicado 2021

Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)

por Voos, Katrin, Schönauer, Esther, Alhayek, Alaa, Haupenthal, Jörg, Andreas, Anastasia, Müller, Rolf, Hartmann, Rolf W., Brandstetter, Hans, Hirsch, Anna K. H., Ducho, Christian
Publicado 2021

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

por Schönauer, Esther, Kany, Andreas M., Haupenthal, Jörg, Hüsecken, Kristina, Hoppe, Isabel J., Voos, Katrin, Yahiaoui, Samir, Elsässer, Brigitta, Ducho, Christian, Brandstetter, Hans, Hartmann, Rolf W.
Publicado 2017

Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

por Kaya, Cansu, Walter, Isabell, Yahiaoui, Samir, Sikandar, Asfandyar, Alhayek, Alaa, Konstantinović, Jelena, Kany, Andreas M., Haupenthal, Jörg, Köhnke, Jesko, Hartmann, Rolf W., Hirsch, Anna K. H.
Publicado 2021

Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers

por Köberle, Verena, Pleli, Thomas, Schmithals, Christian, Augusto Alonso, Eduardo, Haupenthal, Jörg, Bönig, Halvard, Peveling-Oberhag, Jan, Biondi, Ricardo M., Zeuzem, Stefan, Kronenberger, Bernd, Waidmann, Oliver, Piiper, Albrecht
Publicado 2013

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach

por Konstantinidou, Markella, Magari, Francesca, Sutanto, Fandi, Haupenthal, Jörg, Jumde, Varsha R., Ünver, M. Yagiz, Heine, Andreas, Camacho, Carlos Jamie, Hirsch, Anna K. H., Klebe, Gerhard, Dömling, Alexander
Publicado 2020

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

por Yahiaoui, Samir, Voos, Katrin, Haupenthal, Jörg, Wichelhaus, Thomas A., Frank, Denia, Weizel, Lilia, Rotter, Marco, Brunst, Steffen, Kramer, Jan S., Proschak, Ewgenij, Ducho, Christian, Hirsch, Anna K. H.
Publicado 2021

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

por Alhayek, Alaa, Abdelsamie, Ahmed S., Schönauer, Esther, Camberlein, Virgyl, Hutterer, Evelyn, Posselt, Gernot, Serwanja, Jamil, Blöchl, Constantin, Huber, Christian G., Haupenthal, Jörg, Brandstetter, Hans, Wessler, Silja, Hirsch, Anna K. H.
Publicado 2022

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

por Kaya, Cansu, Walter, Isabell, Alhayek, Alaa, Shafiei, Roya, Jézéquel, Gwenaëlle, Andreas, Anastasia, Konstantinović, Jelena, Schönauer, Esther, Sikandar, Asfandyar, Haupenthal, Jörg, Müller, Rolf, Brandstetter, Hans, Hartmann, Rolf W., Hirsch, Anna K.H.
Publicado 2022

N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

por Konstantinović, Jelena, Yahiaoui, Samir, Alhayek, Alaa, Haupenthal, Jörg, Schönauer, Esther, Andreas, Anastasia, Kany, Andreas M., Müller, Rolf, Koehnke, Jesko, Berger, Fabian K., Bischoff, Markus, Hartmann, Rolf W., Brandstetter, Hans, Hirsch, Anna K. H.
Publicado 2020

Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections

por Alhayek, Alaa, Khan, Essak S., Schönauer, Esther, Däinghaus, Tobias, Shafiei, Roya, Voos, Katrin, Han, Mitchell K.L., Ducho, Christian, Posselt, Gernot, Wessler, Silja, Brandstetter, Hans, Haupenthal, Jörg, del Campo, Aránzazu, Hirsch, Anna K.H.
Publicado 2022

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase

por Jumde, Ravindra P., Guardigni, Melissa, Gierse, Robin M., Alhayek, Alaa, Zhu, Di, Hamid, Zhoor, Johannsen, Sandra, Elgaher, Walid A. M., Neusens, Philipp J., Nehls, Christian, Haupenthal, Jörg, Reiling, Norbert, Hirsch, Anna K. H.
Publicado 2021

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

por Bihrer, Verena, Waidmann, Oliver, Friedrich-Rust, Mireen, Forestier, Nicole, Susser, Simone, Haupenthal, Jörg, Welker, Martin, Shi, Ying, Peveling-Oberhag, Jan, Polta, Andreas, von Wagner, Michael, Radeke, Heinfried H., Sarrazin, Christoph, Trojan, Jörg, Zeuzem, Stefan, Kronenberger, Bernd, Piiper, Albrecht
Publicado 2011

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

por Zhu, Di, Johannsen, Sandra, Masini, Tiziana, Simonin, Céline, Haupenthal, Jörg, Illarionov, Boris, Andreas, Anastasia, Awale, Mahendra, Gierse, Robin M., van der Laan, Tridia, van der Vlag, Ramon, Nasti, Rita, Poizat, Mael, Buhler, Eric, Reiling, Norbert, Müller, Rolf, Fischer, Markus, Reymond, Jean-Louis, Hirsch, Anna K. H.
Publicado 2022

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

por Camberlein, Virgyl, Fléau, Charlotte, Sierocki, Pierre, Li, Lenong, Gealageas, Ronan, Bosc, Damien, Guillaume, Valentin, Warenghem, Sandrine, Leroux, Florence, Rosell, Melissa, Cheng, Keguang, Medve, Laura, Prigent, Mathilde, Decanter, Myriam, Piveteau, Catherine, Biela, Alexandre, Eveque, Maxime, Dumont, Julie, Mpakali, Anastasia, Giastas, Petros, Herledan, Adrien, Couturier, Cyril, Haupenthal, Jörg, Lesire, Laetitia, Hirsch, Anna K. H., Deprez, Benoit, Stratikos, Efstratios, Bouvier, Marlene, Deprez‐Poulain, Rebecca
Publicado 2022