The Tango between Cancer-Associated Fibroblasts (CAFs) and Immune Cells in Affecting Immunotherapy Efficacy in Pancreatic Cancer

por Stouten, Imke, van Montfoort, Nadine, Hawinkels, Lukas J. A. C.
Publicado 2023

Fibroblast Subsets in Intestinal Homeostasis, Carcinogenesis, Tumor Progression, and Metastasis

por Dang, Hao, Harryvan, Tom J., Hawinkels, Lukas J. A. C.
Publicado 2021

Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment

por Ouahoud, Sarah, Hardwick, James C.H., Hawinkels, Lukas J.A.C.
Publicado 2020

Endoglin Targeting: Lessons Learned and Questions That Remain

por Liu, Yingmiao, Paauwe, Madelon, Nixon, Andrew B., Hawinkels, Lukas J.A.C.
Publicado 2020

Endoglin: Beyond the Endothelium

por Schoonderwoerd, Mark J. A., Goumans, Marie-Jose T. H., Hawinkels, Lukas J. A. C.
Publicado 2020

The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells

por Harryvan, Tom J., de Lange, Sabine, Hawinkels, Lukas J.A.C., Verdegaal, Els M.E.
Publicado 2021

Multicellular Modelling of Difficult-to-Treat Gastrointestinal Cancers: Current Possibilities and Challenges

por Hakuno, Sarah K., Michiels, Ellis, Kuhlemaijer, Eleonore B., Rooman, Ilse, Hawinkels, Lukas J. A. C., Slingerland, Marije
Publicado 2022

Targeting of the Cancer-Associated Fibroblast—T-Cell Axis in Solid Malignancies

por Harryvan, Tom J., Verdegaal, Els M. E., Hardwick, James C. H., Hawinkels, Lukas J. A. C., van der Burg, Sjoerd H.
Publicado 2019

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

por Cunha, Sara I., Pardali, Evangelia, Thorikay, Midory, Anderberg, Charlotte, Hawinkels, Lukas, Goumans, Marie-José, Seehra, Jasbir, Heldin, Carl-Henrik, ten Dijke, Peter, Pietras, Kristian
Publicado 2010

Targeting Endoglin Expressing Cells in the Tumor Microenvironment Does Not Inhibit Tumor Growth in a Pancreatic Cancer Mouse Model

por Schoonderwoerd, Mark J A, Hakuno, Sarah K, Sassen, Martijn, Kuhlemaijer, Eleonore B, Paauwe, Madelon, Slingerland, Marije, Fransen, Marieke F, Hawinkels, Lukas J A C
Publicado 2021

Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus

por Harryvan, Tom J., Golo, Matteo, Dam, Nicole, Schoonderwoerd, Mark J. A., Farshadi, Elham Aida, Hornsveld, Marten, Hoeben, Rob C., Hawinkels, Lukas J. A. C., Kemp, Vera
Publicado 2022

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

por Kunnen, Steven J., Leonhard, Wouter N., Semeins, Cor, Hawinkels, Lukas J. A. C., Poelma, Christian, ten Dijke, Peter, Bakker, Astrid, Hierck, Beerend P., Peters, Dorien J. M.
Publicado 2017

The impact of CYP2C19 genotype on phenoconversion by concomitant medication

por de Jong, Laura M., Boussallami, Soukayna, Sánchez-López, Elena, Giera, Martin, Tushuizen, Maarten E., Hoekstra, Menno, Hawinkels, Lukas J. A. C., Rissmann, Robert, Swen, Jesse J., Manson, Martijn L.
Publicado 2023

DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression

por Jiménez-Martínez, Marta, Ostalé, Cristina M., van der Burg, Lennart R., Galán-Martínez, Javier, Hardwick, James C. H., López-Pérez, Ricardo, Hawinkels, Lukas J. A. C., Stamatakis, Konstantinos, Fresno, Manuel
Publicado 2019

Crohn’s Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities

por Zhou, Zhou, Ouboter, Laura F., Peeters, Koen C. M. J., Hawinkels, Lukas J. A. C., Holman, Fabian, Pascutti, Maria F., Barnhoorn, Marieke C., van der Meulen-de Jong, Andrea E.
Publicado 2023

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

por Roelands, Jessica, van der Ploeg, Manon, Ijsselsteijn, Marieke E, Dang, Hao, Boonstra, Jurjen J, Hardwick, James C H, Hawinkels, Lukas J A C, Morreau, Hans, de Miranda, Noel F C C
Publicado 2023

IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

por Coffelt, Seth B., Kersten, Kelly, Doornebal, Chris W., Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J.M., Ciampricotti, Metamia, Hawinkels, Lukas J.A.C., Jonkers, Jos, de Visser, Karin E.
Publicado 2015

The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model

por Melis, Monique H.M., Nevedomskaya, Ekaterina, van Burgsteden, Johan, Cioni, Bianca, van Zeeburg, Hester J.T., Song, Ji-Ying, Zevenhoven, John, Hawinkels, Lukas J.A.C, de Visser, Karin E., Bergman, Andries M.
Publicado 2017

Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

por Trietsch, Marjolijn D., Oonk, Maaike H.M., Hawinkels, Lukas J.A.C., Bor, Rosalie, van Eendenburg, Jaap D.H., Ivanova, Zina, Peters, Alexander A.W., Nijman, Hans W., Gaarenstroom, Katja N., Bosse, Tjalling
Publicado 2016

Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation

por Zhou, Zhou, Plug, Leonie G., Patente, Thiago A., de Jonge-Muller, Eveline S. M., Elmagd, Amir Abou, van der Meulen-de Jong, Andrea E., Everts, Bart, Barnhoorn, Marieke C., Hawinkels, Lukas J. A. C.
Publicado 2022