C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a (+/−) mouse model of Dravet syndrome

por Kang, Seok K., Hawkins, Nicole A., Kearney, Jennifer A.
Publicado 2018

Strain-dependent effects on neurobehavioral and seizure phenotypes in Scn2a(K1422E) mice

por Echevarria-Cooper, Dennis M., Hawkins, Nicole A., Kearney, Jennifer A.
Publicado 2023

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

por Hawkins, Nicole A., Lewis, Michael, Hammond, Rebecca S., Doherty, James J., Kearney, Jennifer A.
Publicado 2017

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

por Hawkins, Nicole A., Zachwieja, Nicole J., Miller, Alison R., Anderson, Lyndsey L., Kearney, Jennifer A.
Publicado 2016

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

por Anderson, Lyndsey L., Hawkins, Nicole A., Thompson, Christopher H., Kearney, Jennifer A., George, Alfred L.
Publicado 2017

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

por Hawkins, Nicole A., Anderson, Lyndsey L., Gertler, Tracy S., Laux, Linda, George, Alfred L., Kearney, Jennifer A.
Publicado 2017

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome

por Satpute Janve, Vaishali, Anderson, Lyndsey L., Bahceci, Dilara, Hawkins, Nicole A., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2021

Fine mapping and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11

por Kearney, Jennifer A., Copeland-Hardin, Letonia D., Duarte, Samantha, Zachwieja, Nicole A., Eckart-Frank, Isaiah K., Hawkins, Nicole A.
Publicado 2022

Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant

por Kang, Seok Kyu, Hawkins, Nicole A., Echevarria-Cooper, Dennis M., Baker, Erin M., Dixon, Conor J., Speakes, Nathan, Kearney, Jennifer A.
Publicado 2023

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a(+/)(-) mouse model of Dravet syndrome

por Anderson, Lyndsey L., Bahceci, Dilara A., Hawkins, Nicole A., Everett-Morgan, Declan, Banister, Samuel D., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2023

Gabra2 is a genetic modifier of Dravet syndrome in mice

por Hawkins, Nicole A., Nomura, Toshihiro, Duarte, Samantha, Barse, Levi, Williams, Robert W., Homanics, Gregg E., Mulligan, Megan K., Contractor, Anis, Kearney, Jennifer A.
Publicado 2021

Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant

por Hawkins, Nicole A., Misra, Sunita N, Jurado, Manuel, Kang, Seok Kyu, Vierra, Nicholas C., Nguyen, Kimberly, Wren, Lisa, George, Alfred L., Trimmer, James S., Kearney, Jennifer A.
Publicado 2020

Soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice

por Hawkins, Nicole A., Jurado, Manuel, Thaxton, Tyler T., Duarte, Samantha E., Barse, Levi, Tatsukawa, Tetsuya, Yamakawa, Kazuhiro, Nishi, Toshiya, Kondo, Shinichi, Miyamoto, Maki, Abrahams, Brett S., During, Matthew J., Kearney, Jennifer A.
Publicado 2021

Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy

por Anderson, Lyndsey L., Heblinski, Marika, Absalom, Nathan L., Hawkins, Nicole A., Bowen, Michael T., Benson, Melissa J., Zhang, Fan, Bahceci, Dilara, Doohan, Peter T., Chebib, Mary, McGregor, Iain S., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2021

Cellular and behavioral effects of altered Na(V)1.2 sodium channel ion permeability in Scn2a(K1422E) mice

por Echevarria-Cooper, Dennis M, Hawkins, Nicole A, Misra, Sunita N, Huffman, Alexandra M, Thaxton, Tyler, Thompson, Christopher H, Ben-Shalom, Roy, Nelson, Andrew D, Lipkin, Anna M, George Jr, Alfred L, Bender, Kevin J, Kearney, Jennifer A
Publicado 2022

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

por Forrest, Marc P., Dos Santos, Marc, Piguel, Nicolas H., Wang, Yi-Zhi, Hawkins, Nicole A., Bagchi, Vikram A., Dionisio, Leonardo E., Yoon, Sehyoun, Simkin, Dina, Martin-de-Saavedra, Maria Dolores, Gao, Ruoqi, Horan, Katherine E., George, Alfred L., LeDoux, Mark S., Kearney, Jennifer A., Savas, Jeffrey N., Penzes, Peter
Publicado 2023