More Paths to PI3Kγ

por Stephens, Len, Hawkins, Phillip
Publicado 2013

9. Successful use of IL-6 pathway blockade to treat autoinflammation occurring in the context of a novel TNFRS1A gene mutation

por Dyke, Bernard, Gordon, Caroline, Hawkins, Phillip, Tosounidou, Sofia
Publicado 2019

How is the acyl chain composition of phosphoinositides created and does it matter?

por Barneda, David, Cosulich, Sabina, Stephens, Len, Hawkins, Phillip
Publicado 2019

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment

por Gyori, David, Chessa, Tamara, Hawkins, Phillip T., Stephens, Len R.
Publicado 2017

3D time series analysis of cell shape using Laplacian approaches

por Du, Cheng-Jin, Hawkins, Phillip T, Stephens, Len R, Bretschneider, Till
Publicado 2013

Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells

por Anderson, Karen E., Juvin, Veronique, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T.
Publicado 2016

Neutrophils from p40(phox−/−) mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

por Ellson, Chris D., Davidson, Keith, Ferguson, G. John, O'Connor, Rod, Stephens, Len R., Hawkins, Phillip T.
Publicado 2006

Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop

por Kiselev, Vladimir Yu., Juvin, Veronique, Malek, Mouhannad, Luscombe, Nicholas, Hawkins, Phillip, Novère, Nicolas Le, Stephens, Len
Publicado 2015

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells

por Ross, Sarah H., Rollings, Christina, Anderson, Karen E., Hawkins, Phillip T., Stephens, Len R., Cantrell, Doreen A.
Publicado 2016

Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP(2) in the Mouse

por Anderson, Karen E., Kielkowska, Anna, Durrant, Tom N., Juvin, Veronique, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T.
Publicado 2013

Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses

por Suire, Sabine, Baltanas, Fernando C., Segonds‐Pichon, Anne, Davidson, Keith, Santos, Eugenio, Hawkins, Phillip T., Stephens, Len R.
Publicado 2019

Phosphorylation of threonine 154 in p40(phox) is an important physiological signal for activation of the neutrophil NADPH oxidase

por Chessa, Tamara A. M., Anderson, Karen E., Hu, Yanhua, Xu, Qingbo, Rausch, Oliver, Stephens, Len R., Hawkins, Phillip T.
Publicado 2010

Acyl chain selection couples the consumption and synthesis of phosphoinositides

por Barneda, David, Janardan, Vishnu, Niewczas, Izabella, Collins, Daniel M, Cosulich, Sabina, Clark, Jonathan, Stephens, Len R, Hawkins, Phillip T
Publicado 2022

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

por Zhang, Xuxiao, Vadas, Oscar, Perisic, Olga, Anderson, Karen E., Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R., Williams, Roger L.
Publicado 2011

Quantification of PtdInsP(3) molecular species in cells and tissues by mass spectrometry

por Clark, Jonathan, Anderson, Karen E., Juvin, Veronique, Smith, Trevor S., Karpe, Fredrik, Wakelam, Michael J.O., Stephens, Len R., Hawkins, Phillip T.
Publicado 2011

PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4(+) T Cells

por Luff, Daisy H., Wojdyla, Katarzyna, Oxley, David, Chessa, Tamara, Hudson, Kevin, Hawkins, Phillip T., Stephens, Len R., Barry, Simon T., Okkenhaug, Klaus
Publicado 2021

The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

por Győri, Dávid, Csete, Dániel, Benkő, Szilvia, Kulkarni, Suhasini, Mandl, Péter, Dobó-Nagy, Csaba, Vanhaesebroeck, Bart, Stephens, Len, Hawkins, Phillip T, Mócsai, Attila
Publicado 2014

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

por Vinolo, Marco A. R., Ferguson, G. John, Kulkarni, Suhasini, Damoulakis, George, Anderson, Karen, Bohlooly-Y, Mohammad, Stephens, Len, Hawkins, Phillip T., Curi, Rui
Publicado 2011

Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines

por Juvin, Veronique, Malek, Mouhannad, Anderson, Karen E., Dion, Carine, Chessa, Tamara, Lecureuil, Charlotte, Ferguson, G. John, Cosulich, Sabina, Hawkins, Phillip T., Stephens, Len R.
Publicado 2013

The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin

por Hukelmann, Jens L., Anderson, Karen E., Sinclair, Linda V., Grzes, Katarzyna M., Murillo, Alejandro Brenes, Hawkins, Phillip T., Stephens, Len R., Lamond, Angus I., Cantrell, Doreen A.
Publicado 2015