Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model

por NAKADA, Kazuto, SATO, Akitsugu, HAYASHI, Jun-Ichi
Publicado 2008

Mitochondrial DNA with a Large-Scale Deletion Causes Two Distinct Mitochondrial Disease Phenotypes in Mice

por Katada, Shun, Mito, Takayuki, Ogasawara, Emi, Hayashi, Jun-Ichi, Nakada, Kazuto
Publicado 2013

Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species

por Yamanashi, Haruka, Hashizume, Osamu, Yonekawa, Hiromichi, Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2014

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer

por Koshikawa, Nobuko, Akimoto, Miho, Hayashi, Jun-Ichi, Nagase, Hiroki, Takenaga, Keizo
Publicado 2017

A Specific Nuclear DNA Background Is Required for High Frequency Lymphoma Development in Transmitochondrial Mice with G13997A mtDNA

por Hashizume, Osamu, Yamanashi, Haruka, Taketo, Makoto M., Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2015

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

por Cao, Liqin, Shitara, Hiroshi, Sugimoto, Michihiko, Hayashi, Jun-Ichi, Abe, Kuniya, Yonekawa, Hiromichi
Publicado 2009

Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism

por Mito, Takayuki, Tani, Haruna, Suzuki, Michiko, Ishikawa, Kaori, Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2018

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

por Imanishi, Hirotake, Hattori, Keisuke, Wada, Reiko, Ishikawa, Kaori, Fukuda, Sayaka, Takenaga, Keizo, Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2011

Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders

por Tani, Haruna, Mito, Takayuki, Velagapudi, Vidya, Ishikawa, Kaori, Umehara, Moe, Nakada, Kazuto, Suomalainen, Anu, Hayashi, Jun-Ichi
Publicado 2019

Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation

por Saitoh, Masayuki, Tsuchida, Masanori, Koike, Terumoto, Satoh, Koichi, Haga, Manabu, Aoki, Tadashi, Toyabe, Shin-ichi, Hayashi, Jun-ichi
Publicado 2006

Normal mitochondrial respiratory function is essential for spatial remote memory in mice

por Tanaka, Daisuke, Nakada, Kazuto, Takao, Keizo, Ogasawara, Emi, Kasahara, Atsuko, Sato, Akitsugu, Yonekawa, Hiromichi, Miyakawa, Tsuyoshi, Hayashi, Jun-Ichi
Publicado 2008

A 5-bp Insertion in Mip Causes Recessive Congenital Cataract in KFRS4/Kyo Rats

por Watanabe, Kei, Wada, Kenta, Ohashi, Tomoko, Okubo, Saki, Takekuma, Kensuke, Hashizume, Ryoichi, Hayashi, Jun-Ichi, Serikawa, Tadao, Kuramoto, Takashi, Kikkawa, Yoshiaki
Publicado 2012

Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development

por Mito, Takayuki, Kikkawa, Yoshiaki, Shimizu, Akinori, Hashizume, Osamu, Katada, Shun, Imanishi, Hirotake, Ota, Azusa, Kato, Yukina, Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2013

Selection of Rodent Species Appropriate for mtDNA Transfer to Generate Transmitochondrial Mito-Mice Expressing Mitochondrial Respiration Defects

por Enoki, Shunkei, Shimizu, Akinori, Hayashi, Chisato, Imanishi, Hirotake, Hashizume, Osamu, Mekada, Kazuyuki, Suzuki, Hitoshi, Hashimoto, Tetsuo, Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2014

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

por Tani, Haruna, Ohnishi, Sakiko, Shitara, Hiroshi, Mito, Takayuki, Yamaguchi, Midori, Yonekawa, Hiromichi, Hashizume, Osamu, Ishikawa, Kaori, Nakada, Kazuto, Hayashi, Jun-Ichi
Publicado 2018

A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome

por Kishita, Yoshihito, Ishikawa, Kaori, Nakada, Kazuto, Hayashi, Jun-Ichi, Fushimi, Takuya, Shimura, Masaru, Kohda, Masakazu, Ohtake, Akira, Murayama, Kei, Okazaki, Yasushi
Publicado 2021

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

por Imanishi, Hirotake, Takibuchi, Gaku, Kobayashi, Toshihiko, Ishikawa, Kaori, Nakada, Kazuto, Mori, Masayuki, Kikkawa, Yoshiaki, Takenaga, Keizo, Toyama-Sorimachi, Noriko, Hayashi, Jun-Ichi
Publicado 2013

Mitochondrial DNA deletion-dependent podocyte injuries in Mito-miceΔ, a murine model of mitochondrial disease

por Kaneko, Shuzo, Usui, Joichi, Hagiwara, Masahiro, Shimizu, Tatsuya, Ishii, Ryota, Takahashi-Kobayashi, Mayumi, Kageyama, Mikiko, Nakada, Kazuto, Hayashi, Jun-Ichi, Yamagata, Kunihiro
Publicado 2021

The innate immune system in host mice targets cells with allogenic mitochondrial DNA

por Ishikawa, Kaori, Toyama-Sorimachi, Noriko, Nakada, Kazuto, Morimoto, Mami, Imanishi, Hirotake, Yoshizaki, Mariko, Sasawatari, Shigemi, Niikura, Mamoru, Takenaga, Keizo, Yonekawa, Hiromichi, Hayashi, Jun-Ichi
Publicado 2010

Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNA(Leu(UUR)) with a pathogenic A2748G...

por Tani, Haruna, Ishikawa, Kaori, Tamashiro, Hiroaki, Ogasawara, Emi, Yasukawa, Takehiro, Matsuda, Shigeru, Shimizu, Akinori, Kang, Dongchon, Hayashi, Jun-Ichi, Wei, Fan-Yan, Nakada, Kazuto
Publicado 2022