Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

por Bowden, Jack, Davey Smith, George, Haycock, Philip C., Burgess, Stephen
Publicado 2016

Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort

por Taylor, Michelle, Simpkin, Andrew J., Haycock, Philip C., Dudbridge, Frank, Zuccolo, Luisa
Publicado 2016

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

por Haycock, Philip C, Heydon, Emma E, Kaptoge, Stephen, Butterworth, Adam S, Thompson, Alex, Willeit, Peter
Publicado 2014

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies(1)

por Haycock, Philip C, Burgess, Stephen, Wade, Kaitlin H, Bowden, Jack, Relton, Caroline, Davey Smith, George
Publicado 2016

Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank

por Carreras-Torres, Robert, Johansson, Mattias, Haycock, Philip C, Relton, Caroline L, Davey Smith, George, Brennan, Paul, Martin, Richard M
Publicado 2018

Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors

por Howell, Amy Elizabeth, Zheng, Jie, Haycock, Philip C., McAleenan, Alexandra, Relton, Caroline, Martin, Richard M., Kurian, Kathreena M.
Publicado 2018

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

por Cho, Yoonsu, Haycock, Philip C., Sanderson, Eleanor, Gaunt, Tom R., Zheng, Jie, Morris, Andrew P., Davey Smith, George, Hemani, Gibran
Publicado 2020

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

por Richardson, Tom G, Haycock, Philip C, Zheng, Jie, Timpson, Nicholas J, Gaunt, Tom R, Davey Smith, George, Relton, Caroline L, Hemani, Gibran
Publicado 2018

Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes

por Walker, Venexia M, Davies, Neil M, Hemani, Gibran, Zheng, Jie, Haycock, Philip C, Gaunt, Tom R, Davey Smith, George, Martin, Richard M
Publicado 2019

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK...

por Borges, Maria Carolina, Haycock, Philip C., Zheng, Jie, Hemani, Gibran, Holmes, Michael V., Davey Smith, George, Hingorani, Aroon D., Lawlor, Deborah A.
Publicado 2022

The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study

por Carreras-Torres, Robert, Johansson, Mattias, Gaborieau, Valerie, Haycock, Philip C., Wade, Kaitlin H., Relton, Caroline L., Martin, Richard M., Davey Smith, George, Brennan, Paul
Publicado 2017

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

por Zheng, Jie, Richardson, Tom G, Millard, Louise A C, Hemani, Gibran, Elsworth, Benjamin L, Raistrick, Christopher A, Vilhjalmsson, Bjarni, Neale, Benjamin M, Haycock, Philip C, Smith, George Davey, Gaunt, Tom R
Publicado 2018

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis

por Yarmolinsky, James, Bonilla, Carolina, Haycock, Philip C, Langdon, Ryan J Q, Lotta, Luca A, Langenberg, Claudia, Relton, Caroline L, Lewis, Sarah J, Evans, David M, Davey Smith, George, Martin, Richard M
Publicado 2018

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

por Cortez Cardoso Penha, Ricardo, Smith-Byrne, Karl, Atkins, Joshua R, Haycock, Philip C, Kar, Siddhartha, Codd, Veryan, Samani, Nilesh J, Nelson, Christopher, Milojevic, Maja, Gabriel, Aurélie AG, Amos, Christopher, Brennan, Paul, Hung, Rayjean J, Kachuri, Linda, Mckay, James D
Publicado 2023

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

por Noyce, Alastair J., Kia, Demis A., Hemani, Gibran, Nicolas, Aude, Price, T. Ryan, De Pablo-Fernandez, Eduardo, Haycock, Philip C., Lewis, Patrick A., Foltynie, Thomas, Davey Smith, George, Schrag, Anette, Lees, Andrew J., Hardy, John, Singleton, Andrew, Nalls, Mike A., Pearce, Neil, Lawlor, Debbie A., Wood, Nicholas W.
Publicado 2017

The MR-Base platform supports systematic causal inference across the human phenome

por Hemani, Gibran, Zheng, Jie, Elsworth, Benjamin, Wade, Kaitlin H, Haberland, Valeriia, Baird, Denis, Laurin, Charles, Burgess, Stephen, Bowden, Jack, Langdon, Ryan, Tan, Vanessa Y, Yarmolinsky, James, Shihab, Hashem A, Timpson, Nicholas J, Evans, David M, Relton, Caroline, Martin, Richard M, Davey Smith, George, Gaunt, Tom R, Haycock, Philip C
Publicado 2018

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation...

por Zheng, Jie, Erzurumluoglu, A Mesut, Elsworth, Benjamin L, Kemp, John P, Howe, Laurence, Haycock, Philip C, Hemani, Gibran, Tansey, Katherine, Laurin, Charles, Pourcain, Beate St, Warrington, Nicole M, Finucane, Hilary K, Price, Alkes L, Bulik-Sullivan, Brendan K, Anttila, Verneri, Paternoster, Lavinia, Gaunt, Tom R, Evans, David M, Neale, Benjamin M
Publicado 2017

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

por Baird, Denis A., Liu, Jimmy Z., Zheng, Jie, Sieberts, Solveig K., Perumal, Thanneer, Elsworth, Benjamin, Richardson, Tom G., Chen, Chia-Yen, Carrasquillo, Minerva M., Allen, Mariet, Reddy, Joseph S., De Jager, Philip L., Ertekin-Taner, Nilufer, Mangravite, Lara M., Logsdon, Ben, Estrada, Karol, Haycock, Philip C., Hemani, Gibran, Runz, Heiko, Smith, George Davey, Gaunt, Tom R.
Publicado 2021

Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study

por Dimitrakopoulou, Vasiliki I, Tsilidis, Konstantinos K, Haycock, Philip C, Dimou, Niki L, Al-Dabhani, Kawthar, Martin, Richard M, Lewis, Sarah J, Gunter, Marc J, Mondul, Alison, Shui, Irene M, Theodoratou, Evropi, Nimptsch, Katharina, Lindström, Sara, Albanes, Demetrius, Kühn, Tilman, Key, Timothy J, Travis, Ruth C, Vimaleswaran, Karani Santhanakrishnan, Kraft, Peter, Pierce, Brandon L, Schildkraut, Joellen M
Publicado 2017

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

por Fasanelli, Francesca, Baglietto, Laura, Ponzi, Erica, Guida, Florence, Campanella, Gianluca, Johansson, Mattias, Grankvist, Kjell, Johansson, Mikael, Assumma, Manuela Bianca, Naccarati, Alessio, Chadeau-Hyam, Marc, Ala, Ugo, Faltus, Christian, Kaaks, Rudolf, Risch, Angela, De Stavola, Bianca, Hodge, Allison, Giles, Graham G., Southey, Melissa C., Relton, Caroline L., Haycock, Philip C., Lund, Eiliv, Polidoro, Silvia, Sandanger, Torkjel M., Severi, Gianluca, Vineis, Paolo
Publicado 2015