The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity

por Zhang, Yiguo, Hayes, John D.
Publicado 2013

A partnership with the proteasome; the destructive nature of GSK3

por Robertson, Holly, Hayes, John D., Sutherland, Calum
Publicado 2018

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

por Robertson, Holly, Dinkova-Kostova, Albena T., Hayes, John D.
Publicado 2020

Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains

por Zhang, Yiguo, Ren, Yonggang, Li, Shaojun, Hayes, John D.
Publicado 2014

Necrotic Granulomatous Inflammation after Use of Small Intestine Submucosa Matrix for Recurrent Compression Neuropathy

por Koenig, Zachary A., Burns, Jack C., Hayes, John D.
Publicado 2022

Farming Related Trauma Injuries in Southern West Virginia With a Focus on Risks, Injury Trends, and Associated Co-morbidities

por Viradia, Ravi, Annie, Frank H, Kali, Maher, Hayes, John D, Pollock, Frederic
Publicado 2019

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

por Zhang, Yiguo, Li, Shaojun, Xiang, Yuancai, Qiu, Lu, Zhao, Huakan, Hayes, John D.
Publicado 2015

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

por Chowdhry, Sudhir, Zhang, Yiguo, McMahon, Michael, Sutherland, Calum, Cuadrado, Antonio, Hayes, John D.
Publicado 2012

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

por Fernández-Ginés, Raquel, Encinar, José Antonio, Hayes, John D., Oliva, Baldo, Rodríguez-Franco, Maria Isabel, Rojo, Ana I., Cuadrado, Antonio
Publicado 2022

Corrigendum to “An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver” [R...

por Fernández-Ginés, Raquel, Encinar, José Antonio, Hayes, John D., Oliva, Baldo, Rodríguez-Franco, Maria Isabel, Rojo, Ana I., Cuadrado, Antonio
Publicado 2022

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

por MacLeod, A Kenneth, Acosta-Jimenez, Lourdes, Coates, Philip J, McMahon, Michael, Carey, Frank A, Honda, Tadashi, Hayes, John D, Henderson, Colin J, Wolf, C Roland
Publicado 2017

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Resp...

por Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.
Publicado 2014

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

por Al-Mubarak, Bashayer R., Bell, Karen F.S., Chowdhry, Sudhir, Meakin, Paul J., Baxter, Paul S., McKay, Sean, Dando, Owen, Ashford, Michael L.J., Gazaryan, Irina, Hayes, John D., Hardingham, Giles E.
Publicado 2021

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

por Sharma, Ritu S., Harrison, David J., Kisielewski, Dorothy, Cassidy, Diane M., McNeilly, Alison D., Gallagher, Jennifer R., Walsh, Shaun V., Honda, Tadashi, McCrimmon, Rory J., Dinkova-Kostova, Albena T., Ashford, Michael L.J., Dillon, John F., Hayes, John D.
Publicado 2017

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

por Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.
Publicado 2015