Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion

por Guo, Ne, Li, Meng-Zhu, Wang, Li-Min, Chen, Hua-Dong, Song, Shan-Shan, Miao, Ze-Hong, He, Jin-Xue
Publicado 2022

Acquired resistance of phosphatase and tensin homolog‐deficient cells to poly(ADP‐ribose) polymerase inhibitor and Ara‐C mediated by 53BP1 loss and SAMHD1 overexpression

por Wang, Yu‐Ting, Yuan, Bo, Chen, Hua‐Dong, Xu, Lin, Tian, Yu‐Nan, Zhang, Ao, He, Jin‐Xue, Miao, Ze‐Hong
Publicado 2018

SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy

por Zhou, Li-Na, Xiong, Chaodong, Cheng, Yong-Jun, Song, Shan-Shan, Bao, Xu-Bin, Huan, Xia-Juan, Wang, Tong-Yan, Zhang, Ao, Miao, Ze-Hong, He, Jin-Xue
Publicado 2022

Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer

por Zhang, Ning, Tian, Yu-Nan, Zhou, Li-Na, Li, Meng-Zhu, Chen, Hua-Dong, Song, Shan-Shan, Huan, Xia-Juan, Bao, Xu-Bin, Zhang, Ao, Miao, Ze-Hong, He, Jin-Xue
Publicado 2021

Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance

por Wang, Li‐Min, Wang, Pingyuan, Chen, Xiao‐Min, Yang, Hui, Song, Shan‐Shan, Song, Zilan, Jia, Li, Chen, Hua‐Dong, Bao, Xu‐Bin, Guo, Ne, Huan, Xia‐Juan, Xi, Yong, Shen, Yan‐Yan, Yang, Xin‐Ying, Su, Yi, Sun, Yi‐Ming, Gao, Ying‐Lei, Chen, Yi, Ding, Jian, Lang, Jing‐Yu, Miao, Ze‐Hong, Zhang, Ao, He, Jin‐Xue
Publicado 2023

Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution

por He, Jin-Xue, Wang, Meng, Huan, Xia-Juan, Chen, Chuan-Huizi, Song, Shan-Shan, Wang, Ying-Qing, Liao, Xue-Mei, Tan, Cun, He, Qian, Tong, Lin-Jiang, Wang, Yu-Ting, Li, Xiao-Hua, Su, Yi, Shen, Yan-Yan, Sun, Yi-Ming, Yang, Xin-Ying, Chen, Yi, Gao, Zhi-Wei, Chen, Xiao-Yan, Xiong, Bing, Lu, Xiu-Lian, Ding, Jian, Yang, Chun-Hao, Miao, Ze-Hong
Publicado 2016