Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases

por Gable, Jonathan E., Lee, Gregory M., Jaishankar, Priyadarshini, Hearn, Brian R., Waddling, Christopher A., Renslo, Adam R., Craik, Charles S.
Publicado 2014

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

por Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Publicado 2016

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

por Sidrauski, Carmela, Tsai, Jordan C, Kampmann, Martin, Hearn, Brian R, Vedantham, Punitha, Jaishankar, Priyadarshini, Sokabe, Masaaki, Mendez, Aaron S, Newton, Billy W, Tang, Edward L, Verschueren, Erik, Johnson, Jeffrey R, Krogan, Nevan J, Fraser, Christopher S, Weissman, Jonathan S, Renslo, Adam R, Walter, Peter
Publicado 2015

Pharmacological brake-release of mRNA translation enhances cognitive memory

por Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter
Publicado 2013

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

por Heise, Christopher E., Murray, Jeremy, Augustyn, Katherine E., Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M., Gibbons, Paul, Hannoush, Rami N., Hearn, Brian R., Jaishankar, Priyadarshini, Ly, Cuong Q., Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W., Renslo, Adam R., Flygare, John, Arkin, Michelle R.
Publicado 2012