Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase inhibitors and inherent therapeutic vulnerabilities

por Kleczko, Emily K., Heasley, Lynn E.
Publicado 2018

Co-dependency of PKCδ and K-Ras: Inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer

por Ohm, Angela M., Tan, Aik-Choon, Heasley, Lynn E., Reyland, Mary E.
Publicado 2017

Evaluation of KRAS(G12C) inhibitor responses in novel murine KRAS(G12C) lung cancer cell line models

por Sisler, Daniel J., Hinz, Trista K., Le, Anh T., Kleczko, Emily K., Nemenoff, Raphael A., Heasley, Lynn E.
Publicado 2023

A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes

por Schubert, Laura, Le, Anh T., Hinz, Trista K., Navarro, Andre, Nelson-Taylor, Sarah K., Nemenoff, Raphael A., Heasley, Lynn E., Doebele, Robert C.
Publicado 2023

A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes

por Schubert, Laura, Le, Anh T., Hinz, Trista K., Navarro, Andre C., Nelson-Taylor, Sarah K., Nemenoff, Raphael A., Heasley, Lynn E., Doebele, Robert C.
Publicado 2023

Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

por Ware, Kathryn E., Marshall, Marianne E., Heasley, Lydia R., Marek, Lindsay, Hinz, Trista K., Hercule, Paula, Helfrich, Barbara A., Doebele, Robert C., Heasley, Lynn E.
Publicado 2010

Heterotrimeric G-Protein, G(α16), Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer

por Avasarala, Sreedevi, Bikkavilli, Rama Kamesh, Van Scoyk, Michelle, Zhang, Wei, Lapite, Ajibike, Hostetter, Logan, Byers, Joshua T., Heasley, Lynn E., Sohn, Jang Won, Winn, Robert A.
Publicado 2013

Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response

por Korpela, Sean P., Hinz, Trista K., Oweida, Ayman, Kim, Jihye, Calhoun, Jacob, Ferris, Robert, Nemenoff, Raphael A., Karam, Sana D., Clambey, Eric T., Heasley, Lynn E.
Publicado 2021

Jnk2 Effects on Tumor Development, Genetic Instability and Replicative Stress in an Oncogene-Driven Mouse Mammary Tumor Model

por Chen, Peila, O'Neal, Jamye F., Ebelt, Nancy D., Cantrell, Michael A., Mitra, Shreya, Nasrazadani, Azadeh, Vandenbroek, Tracy L., Heasley, Lynn E., Van Den Berg, Carla L.
Publicado 2010

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer

por Pilling, Amanda B., Kim, Jihye, Estrada-Bernal, Adriana, Zhou, Qiong, Le, Anh T., Singleton, Katherine R., Heasley, Lynn E., Tan, Aik Choon, DeGregori, James, Doebele, Robert C.
Publicado 2018

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

por Kleczko, Emily K., Kim, Jihye, Keysar, Stephen B., Heasley, Lydia R., Eagles, Justin R., Simon, Matthew, Marshall, Marianne E., Singleton, Katherine R., Jimeno, Antonio, Tan, Aik-Choon, Heasley, Lynn E.
Publicado 2015

An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

por Ryall, Karen A, Kim, Jihye, Klauck, Peter J, Shin, Jimin, Yoo, Minjae, Ionkina, Anastasia, Pitts, Todd M, Tentler, John J, Diamond, Jennifer R, Eckhardt, S Gail, Heasley, Lynn E, Kang, Jaewoo, Tan, Aik Choon
Publicado 2015

A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer

por Gurule, Natalia J., McCoach, Caroline E., Hinz, Trista K., Merrick, Daniel T., Van Bokhoven, Adriaan, Kim, Jihye, Patil, Tejas, Calhoun, Jacob, Nemenoff, Raphael A., Tan, Aik Choon, Doebele, Robert C., Heasley, Lynn E.
Publicado 2021

Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer

por Davies, Kurtis D., Mahale, Sakshi, Astling, David P., Aisner, Dara L., Le, Anh T., Hinz, Trista K., Vaishnavi, Aria, Bunn, Paul A., Heasley, Lynn E., Tan, Aik-Choon, Camidge, D. Ross, Varella-Garcia, Marileila, Doebele, Robert C.
Publicado 2013

Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer

por Zhang, Liping, Yu, Hui, Badzio, Andrzej, Boyle, Theresa A., Schildhaus, Hans-Ulrich, Lu, Xian, Dziadziuszko, Rafal, Jassem, Jacek, Varella-Garcia, Marileila, Heasley, Lynn E., Kowalewski, Ashley A., Ellison, Kim, Chen, Gang, Zhou, Caicun, Hirsch, Fred R.
Publicado 2015

Mer or Axl Receptor Tyrosine Kinase Inhibition Promotes Apoptosis, Blocks Growth, and Enhances Chemosensitivity of Human Non-Small Cell Lung Cancer

por Linger, Rachel M.A., Cohen, Rebecca A., Cummings, Christopher T., Sather, Susan, Migdall-Wilson, Justine, Middleton, Deryck H.G., Lu, Xian, Barón, Anna E., Franklin, Wilbur A., Merrick, Daniel T., Jedlicka, Paul, DeRyckere, Deborah, Heasley, Lynn E., Graham, Douglas K.
Publicado 2012

Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms

por Neuwelt, Alexander J, Kimball, Abigail K, Johnson, Amber M, Arnold, Benjamin W, Bullock, Bonnie L, Kaspar, Rachael E, Kleczko, Emily K, Kwak, Jeff W, Wu, Meng-Han, Heasley, Lynn E, Doebele, Robert C, Li, Howard Y, Nemenoff, Raphael A, Clambey, Eric T
Publicado 2020

Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity

por Kleczko, Emily K., Hinz, Trista K., Nguyen, Teresa T., Gurule, Natalia J., Navarro, Andre, Le, Anh T., Johnson, Amber M., Kwak, Jeff, Polhac, Diana I., Clambey, Eric T., Weiser-Evans, Mary, Merrick, Daniel T., Yang, Michael C., Patil, Tejas, Schenk, Erin L., Heasley, Lynn E., Nemenoff, Raphael A.
Publicado 2023

Upregulation of complement proteins in lung cancer cells mediates tumor progression

por Kleczko, Emily K., Poczobutt, Joanna M., Navarro, Andre C., Laskowski, Jennifer, Johnson, Amber M., Korpela, Sean P., Gurule, Natalia J., Heasley, Lynn E., Hopp, Katharina, Weiser-Evans, Mary C.M., Gottlin, Elizabeth B., Bushey, Ryan T., Campa, Michael J., Patz, Edward F., Thurman, Joshua M., Nemenoff, Raphael A.
Publicado 2023

EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment

por Bhatia, Shilpa, Nguyen, Diemmy, Darragh, Laurel B., Van Court, Benjamin, Sharma, Jaspreet, Knitz, Michael W., Piper, Miles, Bukkapatnam, Sanjana, Gadwa, Jacob, Bickett, Thomas E., Bhuvane, Shiv, Corbo, Sophia, Wu, Brian, Lee, Yichien, Fujita, Mayumi, Joshi, Molishree, Heasley, Lynn E., Ferris, Robert L., Rodriguez, Olga, Albanese, Christopher, Kapoor, Mohit, Pasquale, Elena B., Karam, Sana D.
Publicado 2022