Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes

por Duong, Minh Ngoc, Erdes, Efe, Hebeisen, Michael, Rufer, Nathalie
Publicado 2019

Constant regulation for stable CD8 T‐cell functional avidity and its possible implications for cancer immunotherapy

por Gilfillan, Connie B., Hebeisen, Michael, Rufer, Nathalie, Speiser, Daniel E.
Publicado 2021

Identification and isolation of high avidity tumor-specific CD8 T cells by experimentally assessing pMHC-TCR binding parameters with soluble pMHC complexes

por Schmidt, Julien, Hebeisen, Michael, Guillaume, Philippe, Magnin, Morgane, Rufer, Nathalie, Luescher, Immanuel
Publicado 2015

Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer

por Hebeisen, Michael, Oberle, Susanne G., Presotto, Danilo, Speiser, Daniel E., Zehn, Dietmar, Rufer, Nathalie
Publicado 2013

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens

por Hebeisen, Michael, Allard, Mathilde, Gannon, Philippe O., Schmidt, Julien, Speiser, Daniel E., Rufer, Nathalie
Publicado 2015

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

por Couturaud, Barbara, Doix, Bastien, Carretero-Iglesia, Laura, Allard, Mathilde, Pradervand, Sylvain, Hebeisen, Michael, Rufer, Nathalie
Publicado 2023

Heterogeneity assessment of functional T cell avidity

por Ioannidou, Kalliopi, Baumgaertner, Petra, Gannon, Philippe O., Speiser, Michel F., Allard, Mathilde, Hebeisen, Michael, Rufer, Nathalie, Speiser, Daniel E.
Publicado 2017

High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

por Carretero-Iglesia, Laura, Couturaud, Barbara, Baumgaertner, Petra, Schmidt, Julien, Maby-El Hajjami, Hélène, Speiser, Daniel E., Hebeisen, Michael, Rufer, Nathalie
Publicado 2020

Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms

por Presotto, Danilo, Erdes, Efe, Duong, Minh Ngoc, Allard, Mathilde, Regamey, Pierre-Olivier, Quadroni, Manfredo, Doucey, Marie-Agnès, Rufer, Nathalie, Hebeisen, Michael
Publicado 2017

CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity

por Baumgaertner, Petra, Schmidt, Julien, Costa-Nunes, Carla-Marisa, Bordry, Natacha, Guillaume, Philippe, Luescher, Immanuel, Speiser, Daniel E., Rufer, Nathalie, Hebeisen, Michael
Publicado 2022

Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density

por Gilfillan, Connie B., Wang, Chensu, Mohsen, Mona O., Rufer, Nathalie, Hebeisen, Michael, Allard, Mathilde, Verdeil, Grégory, Irvine, Darrell J., Bachmann, Martin F., Speiser, Daniel E.
Publicado 2019

NK cells specifically TCR-dressed to kill cancer cells

por Mensali, Nadia, Dillard, Pierre, Hebeisen, Michael, Lorenz, Susanne, Theodossiou, Theodossis, Myhre, Marit Renée, Fåne, Anne, Gaudernack, Gustav, Kvalheim, Gunnar, Myklebust, June Helen, Inderberg, Else Marit, Wälchli, Sébastien
Publicado 2019

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4(+) T cells

por Rath, Jan A., Bajwa, Gagan, Carreres, Benoit, Hoyer, Elisabeth, Gruber, Isabelle, Martínez-Paniagua, Melisa A., Yu, Yi-Ru, Nouraee, Nazila, Sadeghi, Fatemeh, Wu, Mengfen, Wang, Tao, Hebeisen, Michael, Rufer, Nathalie, Varadarajan, Navin, Ho, Ping-Chih, Brenner, Malcolm K., Gfeller, David, Arber, Caroline
Publicado 2020

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors

por Schmidt, Julien, Chiffelle, Johanna, Perez, Marta A. S., Magnin, Morgane, Bobisse, Sara, Arnaud, Marion, Genolet, Raphael, Cesbron, Julien, Barras, David, Navarro Rodrigo, Blanca, Benedetti, Fabrizio, Michel, Alexandra, Queiroz, Lise, Baumgaertner, Petra, Guillaume, Philippe, Hebeisen, Michael, Michielin, Olivier, Nguyen-Ngoc, Tu, Huber, Florian, Irving, Melita, Tissot-Renaud, Stéphanie, Stevenson, Brian J., Rusakiewicz, Sylvie, Dangaj Laniti, Denarda, Bassani-Sternberg, Michal, Rufer, Nathalie, Gfeller, David, Kandalaft, Lana E., Speiser, Daniel E., Zoete, Vincent, Coukos, George, Harari, Alexandre
Publicado 2023