A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of Metastatic KRAS Mutant Colorectal Adenocar...

por Hecht, J. Randolph, Benson, Al B., Vyushkov, Dmitry, Yang, Yingsi, Bendell, Johanna, Verma, Udit
Publicado 2017

A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma...

por Benson, Al B., Wainberg, Zev A., Hecht, J. Randolph, Vyushkov, Dmitry, Dong, Hua, Bendell, Johanna, Kudrik, Fred
Publicado 2017

A Phase I, multicenter, open-label trial to evaluate the safety of talimogene laherparepvec (T-VEC) injected into liver tumors

por Hecht, J Randolph, Raman, Steven, Sze, Daniel Y, Lockhart, A Craig, Moss, Rebecca A, Liu, Kate, Chou, Jeffrey, Reid, Tony
Publicado 2015

5-Fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study

por Hecht, J Randolph, Mitchell, Edith P, Yoshino, Takayuki, Welslau, Manfred, Lin, Xun, Chow Maneval, Edna, Paolini, Jolanda, Lechuga, Maria Jose, Kretzschmar, Albrecht
Publicado 2015

Final analysis of the randomised PEAK trial: overall survival and tumour responses during first-line treatment with mFOLFOX6 plus either panitumumab or bevacizumab in patients with...

por Rivera, Fernando, Karthaus, Meinolf, Hecht, J. Randolph, Sevilla, Isabel, Forget, Frédéric, Fasola, Gianpiero, Canon, Jean-Luc, Guan, Xuesong, Demonty, Gaston, Schwartzberg, Lee S.
Publicado 2017

Meta-analysis examining overall survival in patients with pancreatic cancer treated with second-line 5-fluorouracil and oxaliplatin-based therapy after failing first-line gemcitabi...

por Wainberg, Zev A., Feeney, Kynan, Lee, Myung Ah, Muñoz, Andrés, Gracián, Antonio Cubillo, Lonardi, Sara, Ryoo, Baek-Yeol, Hung, Annie, Lin, Yong, Bendell, Johanna, Hecht, J. Randolph
Publicado 2020

Fecal and Tissue Microbiota Are Associated with Tumor T-Cell Infiltration and Mesenteric Lymph Node Involvement in Colorectal Cancer

por Luu, Kayti, Ye, Jason Y., Lagishetty, Venu, Liang, Fengting, Hauer, Megan, Sedighian, Farzaneh, Kwaan, Mary R., Kazanjian, Kevork K., Hecht, J. Randolph, Lin, Anne Y., Jacobs, Jonathan P.
Publicado 2023

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

por Diaz, Luis A., Williams, Richard, Wu, Jian, Kinde, Isaac, Hecht, J. Randolph, Berlin, Jordan, Allen, Benjamin, Bozic, Ivana, Reiter, Johannes G., Nowak, Martin A., Kinzler, Kenneth W., Oliner, Kelly S., Vogelstein, Bert
Publicado 2012

Randomized Phase III Study of FOLFOX Alone or With Pegilodecakin as Second-Line Therapy in Patients With Metastatic Pancreatic Cancer That Progressed After Gemcitabine (SEQUOIA)

por Hecht, J. Randolph, Lonardi, Sara, Bendell, Johanna, Sim, Hao-Wen, Macarulla, Teresa, Lopez, Charles D., Van Cutsem, Eric, Muñoz Martin, Andres J., Park, Joon Oh, Greil, Richard, Wang, Hong, Hozak, Rebecca R., Gueorguieva, Ivelina, Lin, Yong, Rao, Sujata, Ryoo, Baek-Yeol
Publicado 2021

Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

por Burzykowski, Tomasz, Coart, Elisabeth, Saad, Everardo D., Shi, Qian, Sommeijer, Dirkje W., Bokemeyer, Carsten, Díaz-Rubio, Eduardo, Douillard, Jean-Yves, Falcone, Alfredo, Fuchs, Charles S., Goldberg, Richard M., Hecht, J. Randolph, Hoff, Paulo M., Hurwitz, Herbert, Kabbinavar, Fairooz F., Koopman, Miriam, Maughan, Timothy S., Punt, Cornelis J. A., Saltz, Leonard, Schmoll, Hans-Joachim, Seymour, Matthew T., Tebbutt, Niall C., Tournigand, Christophe, Van Cutsem, Eric, de Gramont, Aimery, Zalcberg, John R., Buyse, Marc
Publicado 2019

Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis

por Yin, Jun, Dawood, Shaheenah, Cohen, Romain, Meyers, Jeff, Zalcberg, John, Yoshino, Takayuki, Seymour, Matthew, Maughan, Tim, Saltz, Leonard, Van Cutsem, Eric, Venook, Alan, Schmoll, Hans-Joachim, Goldberg, Richard, Hoff, Paulo, Hecht, J. Randolph, Hurwitz, Herbert, Punt, Cornelis, Diaz Rubio, Eduard, Koopman, Miriam, Cremolini, Chiara, Heinemann, Volker, Tournigard, Christophe, Bokemeyer, Carsten, Fuchs, Charles, Tebbutt, Niall, Souglakos, John, Doulliard, Jean-Yves, Kabbinavar, Fairooz, Chibaudel, Benoist, de Gramont, Aimery, Shi, Qian, Grothey, Axel, Adams, Richard
Publicado 2021

Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCAD Database

por Ou, Fang-Shu, Ahn, Daniel H., Dixon, Jesse G., Grothey, Axel, Lou, Yiyue, Kasi, Pashtoon M., Hubbard, Joleen M., Van Cutsem, Eric, Saltz, Leonard B., Schmoll, Hans-Joachim, Goldberg, Richard M., Venook, Alan P., Hoff, Paulo, Douillard, Jean-Yves, Hecht, J. Randolph, Hurwitz, Herbert, Punt, Cornelis J. A., Koopman, Miriam, Bokemeyer, Carsten, Fuchs, Charles S., Diaz-Rubio, Eduardo, Tebbutt, Niall C., Cremolini, Chiara, Kabbinavar, Fairooz F., Bekaii-Saab, Tanios, Chibaudel, Benoist, Yoshino, Takayuki, Zalcberg, John, Adams, Richard A., de Gramont, Aimery, Shi, Qian
Publicado 2023