Multiple genetically engineered humanized microenvironments in a single mouse

por Lee, Jungwoo, Heckl, Dirk, Parekkadan, Biju
Publicado 2016

The Regulatory Roles of Long Noncoding RNAs in Acute Myeloid Leukemia

por Ng, Michelle, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2019

Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome

por Grimm, Juliane, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2021

PB1813: REGULATORY MECHANISMS AND THERAPEUTIC POTENTIAL OF THE DLK1-DIO3 LOCUS IN PEDIATRIC ACUTE MEGAKARYOBLASTIC LEUKEMIA

por Verboon, Lonneke, Issa, Hasan, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

Long noncoding RNAs as regulators of pediatric acute myeloid leukemia

por Neyazi, Sina, Ng, Michelle, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2022

P419: HARNESSING MIRNA-193B-3P MIMIC AS A POTENT THERAPEUTIC OPTION IN ACUTE MYELOID LEUKEMIA

por Issa, Hasan, Bhayadia, Raj, Winkler, Robert, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

por Grimm, Juliane, Bhayadia, Raj, Gack, Lucie, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2022

Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias

por Issa, Hasan, Bhayadia, Raj, Winkler, Robert, Swart, Laura Elise, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

RNA-Binding Proteins in Acute Leukemias

por Schuschel, Konstantin, Helwig, Matthias, Hüttelmaier, Stefan, Heckl, Dirk, Klusmann, Jan-Henning, Hoell, Jessica I
Publicado 2020

P467: LONG NON-CODING RNA SNHG29 IS A NOVEL MYELOID LEUKEMIA DEPENDENCY

por Winkler, Robert, Heckl, Dirk, Ng, Michelle, Boon, Reinier, Issa, Hasan, Bhayadia, Raj, Klusmann, Jan-Henning
Publicado 2023

Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia

por Sharma, Amit, Jyotsana, Nidhi, Gabdoulline, Razif, Heckl, Dirk, Kuchenbauer, Florian, Slany, Robert K., Ganser, Arnold, Heuser, Michael
Publicado 2020

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

por Reimer, Jana, Knöß, Sabine, Labuhn, Maurice, Charpentier, Emmanuelle M., Göhring, Gudrun, Schlegelberger, Brigitte, Klusmann, Jan-Henning, Heckl, Dirk
Publicado 2017

Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications

por Labuhn, Maurice, Adams, Felix F, Ng, Michelle, Knoess, Sabine, Schambach, Axel, Charpentier, Emmanuelle M, Schwarzer, Adrian, Mateo, Juan L, Klusmann, Jan-Henning, Heckl, Dirk
Publicado 2018

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

por Heckl, Dirk, Kowalczyk, Monika S., Yudovich, David, Belizaire, Roger, Puram, Rishi V., McConkey, Marie E., Thielke, Anne, Aster, Jon C., Regev, Aviv, Ebert, Benjamin L.
Publicado 2014

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

por Kowalczyk, Monika S., Tirosh, Itay, Heckl, Dirk, Rao, Tata Nageswara, Dixit, Atray, Haas, Brian J., Schneider, Rebekka K., Wagers, Amy J., Ebert, Benjamin L., Regev, Aviv
Publicado 2015

Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout

por Knopp, Yvonne, Geis, Franziska K., Heckl, Dirk, Horn, Stefan, Neumann, Thomas, Kuehle, Johannes, Meyer, Janine, Fehse, Boris, Baum, Christopher, Morgan, Michael, Meyer, Johann, Schambach, Axel, Galla, Melanie
Publicado 2018

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15

por Ng, Michelle, Verboon, Lonneke, Issa, Hasan, Bhayadia, Raj, Vermunt, Marit Willemijn, Winkler, Robert, Schüler, Leah, Alejo, Oriol, Schuschel, Konstantin, Regenyi, Eniko, Borchert, Dorit, Heuser, Michael, Reinhardt, Dirk, Yaspo, Marie-Laure, Heckl, Dirk, Klusmann, Jan-Henning
Publicado 2023

LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1

por Logotheti, Stella, Marquardt, Stephan, Gupta, Shailendra K., Richter, Christin, Edelhäuser, Berdien A.H., Engelmann, David, Brenmoehl, Julia, Söhnchen, Christoph, Murr, Nico, Alpers, Michael, Singh, Krishna P., Wolkenhauer, Olaf, Heckl, Dirk, Spitschak, Alf, Pützer, Brigitte M.
Publicado 2020

Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)

por Meyer, Tatjana, Jahn, Nikolaus, Lindner, Stefanie, Röhner, Linda, Dolnik, Anna, Weber, Daniela, Scheffold, Annika, Köpff, Simon, Paschka, Peter, Gaidzik, Verena I., Heckl, Dirk, Wiese, Sebastian, Ebert, Benjamin L., Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze, Krönke, Jan
Publicado 2019

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

por Kloos, Arnold, Mintzas, Konstantinos, Winckler, Lina, Gabdoulline, Razif, Alwie, Yasmine, Jyotsana, Nidhi, Kattre, Nadine, Schottmann, Renate, Scherr, Michaela, Gupta, Charu, Adams, Felix F., Schwarzer, Adrian, Heckl, Dirk, Schambach, Axel, Imren, Suzan, Humphries, R. Keith, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Publicado 2020