Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates

por Heckmann, David, Zielinski, Daniel C., Palsson, Bernhard O.
Publicado 2018

Modeling photosynthetic resource allocation connects physiology with evolutionary environments

por Sundermann, Esther M., Lercher, Martin J., Heckmann, David
Publicado 2021

BLISTER Regulates Polycomb-Target Genes, Represses Stress-Regulated Genes and Promotes Stress Responses in Arabidopsis thaliana

por Kleinmanns, Julia A., Schatlowski, Nicole, Heckmann, David, Schubert, Daniel
Publicado 2017

Deep learning allows genome-scale prediction of Michaelis constants from structural features

por Kroll, Alexander, Engqvist, Martin K. M., Heckmann, David, Lercher, Martin J.
Publicado 2021

A biochemically-interpretable machine learning classifier for microbial GWAS

por Kavvas, Erol S., Yang, Laurence, Monk, Jonathan M., Heckmann, David, Palsson, Bernhard O.
Publicado 2020

Independent component analysis recovers consistent regulatory signals from disparate datasets

por Sastry, Anand V., Hu, Alyssa, Heckmann, David, Poudel, Saugat, Kavvas, Erol, Palsson, Bernhard O.
Publicado 2021

Energetic basis for bird ontogeny and egg-laying applied to the bobwhite quail

por Marn, Nina, Lika, Konstadia, Augustine, Starrlight, Goussen, Benoit, Ebeling, Markus, Heckmann, David, Gergs, Andre
Publicado 2022

The role of photorespiration during the evolution of C(4) photosynthesis in the genus Flaveria

por Mallmann, Julia, Heckmann, David, Bräutigam, Andrea, Lercher, Martin J, Weber, Andreas PM, Westhoff, Peter, Gowik, Udo
Publicado 2014

Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes

por Mih, Nathan, Monk, Jonathan M., Fang, Xin, Catoiu, Edward, Heckmann, David, Yang, Laurence, Palsson, Bernhard O.
Publicado 2020

Quantitative Comparison of Avian and Mammalian Physiologies for Parameterization of Physiologically Based Kinetic Models

por Scanes, Colin G., Witt, Johannes, Ebeling, Markus, Schaller, Stephan, Baier, Vanessa, Bone, Audrey J., Preuss, Thomas G., Heckmann, David
Publicado 2022

Quantitative Morphometric, Physiological, and Metabolic Characteristics of Chickens and Mallards for Physiologically Based Kinetic Model Development

por Scanes, Colin G., Witt, Johannes, Ebeling, Markus, Schaller, Stephan, Baier, Vanessa, Bone, Audrey J., Preuss, Thomas G., Heckmann, David
Publicado 2022

Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity

por Phaneuf, Patrick V., Yurkovich, James T., Heckmann, David, Wu, Muyao, Sandberg, Troy E., King, Zachary A., Tan, Justin, Palsson, Bernhard O., Feist, Adam M.
Publicado 2020

Machine learning applied to enzyme turnover numbers reveals protein structural correlates and improves metabolic models

por Heckmann, David, Lloyd, Colton J., Mih, Nathan, Ha, Yuanchi, Zielinski, Daniel C., Haiman, Zachary B., Desouki, Abdelmoneim Amer, Lercher, Martin J., Palsson, Bernhard O.
Publicado 2018

Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers

por Heckmann, David, Campeau, Anaamika, Lloyd, Colton J., Phaneuf, Patrick V., Hefner, Ying, Carrillo-Terrazas, Marvic, Feist, Adam M., Gonzalez, David J., Palsson, Bernhard O.
Publicado 2020

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

por Kavvas, Erol S., Catoiu, Edward, Mih, Nathan, Yurkovich, James T., Seif, Yara, Dillon, Nicholas, Heckmann, David, Anand, Amitesh, Yang, Laurence, Nizet, Victor, Monk, Jonathan M., Palsson, Bernhard O.
Publicado 2018