Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction

por Heeran, Aisling B., McCready, Jessica, Dunne, Margaret R., Donlon, Noel E., Nugent, Timothy S., Bhardwaj, Anshul, Mitchelson, Kathleen A. J., Buckley, Amy M., Ravi, Narayanasamy, Roche, Helen M., Reynolds, John V., Lynam-Lennon, Niamh, O’Sullivan, Jacintha
Publicado 2021

Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer

por Donlon, Noel E, Davern, Maria, Sheppard, Andrew, O'Connell, Fiona, Moran, Brendan, Nugent, Timothy S, Heeran, Aisling, Phelan, James J, Bhardwaj, Anshul, Butler, Christine, Ravi, Narayanasamy, Donohoe, Claire L, Lynam-Lennon, Niamh, Maher, Stephen, Reynolds, John V, Lysaght, Joanne
Publicado 2023

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses

por Heeran, Aisling B., Dunne, Margaret R., Morrissey, Maria E., Buckley, Croí E., Clarke, Niamh, Cannon, Aoife, Donlon, Noel E., Nugent, Timothy S., Durand, Michael, Dunne, Cara, Larkin, John O., Mehigan, Brian, McCormick, Paul, Lynam-Lennon, Niamh, O’Sullivan, Jacintha
Publicado 2021

Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma

por Donlon, Noel E, Davern, Maria, O’Connell, Fiona, Sheppard, Andrew, Heeran, Aisling, Bhardwaj, Anshul, Butler, Christine, Narayanasamy, Ravi, Donohoe, Claire, Phelan, James J, Lynam-Lennon, Niamh, Dunne, Margaret R, Maher, Stephen, O’Sullivan, Jacintha, Reynolds, John V, Lysaght, Joanne
Publicado 2022

The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling

por Donlon, Noel E., Davern, Maria, Sheppard, Andrew, Power, Robert, O’Connell, Fiona, Heeran, Aisling B., King, Ross, Hayes, Conall, Bhardwaj, Anshul, Phelan, James J., Dunne, Margaret R., Ravi, Narayanasamy, Donohoe, Claire L., O’Sullivan, Jacintha, Reynolds, John V., Lysaght, Joanne
Publicado 2021

Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model

por Heeran, Aisling B., Berrigan, Helen P., Buckley, Croí E., Bottu, Heleena Moni, Prendiville, Orla, Buckley, Amy M., Clarke, Niamh, Donlon, Noel E., Nugent, Timothy S., Durand, Michael, Dunne, Cara, Larkin, John O., Mehigan, Brian, McCormick, Paul, Brennan, Lorraine, Lynam-Lennon, Niamh, O'Sullivan, Jacintha
Publicado 2020

PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistan...

por Davern, Maria, Fitzgerald, Marie-Claire, Buckley, Croí E., Heeran, Aisling B., Donlon, Noel E., McGrath, Jason, O’ Connell, Fiona, Deshpande, Malvika R., Hayes, Conall, MacDonald, Jamie, Sheppard, Andrew D., Reynolds, John V., Maher, Stephen G., Lynam-Lennon, Niamh, Murphy, Brona, Lysaght, Joanne
Publicado 2022

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Me...

por Slater, Kayleigh, Heeran, Aisling B., Garcia-Mulero, Sandra, Kalirai, Helen, Sanz-Pamplona, Rebeca, Rahman, Arman, Al-Attar, Nebras, Helmi, Mays, O’Connell, Fiona, Bosch, Rosa, Portela, Anna, Villanueva, Alberto, Gallagher, William M., Jensen, Lasse D., Piulats, Josep M., Coupland, Sarah E., O’Sullivan, Jacintha, Kennedy, Breandán N.
Publicado 2020

Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients...

por O’Connell, Fiona, Mylod, Eimear, Donlon, Noel E., Heeran, Aisling B., Butler, Christine, Bhardwaj, Anshul, Ramjit, Sinead, Durand, Michael, Lambe, Gerard, Tansey, Paul, Welartne, Ivan, Sheahan, Kevin P., Yin, Xiaofei, Donohoe, Claire L., Ravi, Narayanasamy, Dunne, Margaret R., Brennan, Lorraine, Reynolds, John V., Roche, Helen M., O’Sullivan, Jacintha
Publicado 2023

FLOT and CROSS chemotherapy regimens alter the frequency of CD27(+) and CD69(+) T cells in oesophagogastric adenocarcinomas: implications for combination with immunotherapy

por Davern, Maria, Donlon, Noel E., Sheppard, Andrew S., Majcher, Klaudia D., Connell, Fiona O’, Heeran, Aisling B., Grant, Malika, Farrell, Robert A., Hayes, Conall, Bracken-Clarke, Dara, Conroy, Melissa J., Foley, Emma, Toole, Dermot O’, Bhardwaj, Anshul, Ravi, Narayanasamy, Reynolds, John V., Maher, Stephen G., Sullivan, Jacintha O’, Lysaght, Joanne
Publicado 2022

Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells

por Davern, Maria, Bracken-Clarke, Dara, Donlon, Noel E., Sheppard, Andrew D., Connell, Fiona O’, Heeran, Aisling B., Majcher, Klaudia, Conroy, Melissa J., Mylod, Eimear, Butler, Christine, Donohoe, Claire, Donnell, Dearbhaile O’, Lowery, Maeve, Bhardwaj, Anshul, Ravi, Narayanasamy, Melo, Ashanty A., Sullivan, Jacintha O’, Reynolds, John V., Lysaght, Joanne
Publicado 2023