Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G(1 )checkpoint function

por Simpson, Dennis A, Livanos, Elizabeth, Heffernan, Timothy P, Kaufmann, William K
Publicado 2005

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research

por Inoue, Akira, Deem, Angela K., Kopetz, Scott, Heffernan, Timothy P., Draetta, Giulio F., Carugo, Alessandro
Publicado 2019

HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome

por Wardwell-Ozgo, Joanna, Dogruluk, Turgut, Gifford, Armel, Zhang, Yiqun, Heffernan, Timothy P., van Doorn, Remco, Creighton, Chad J., Chin, Lynda, Scott, Kenneth L.
Publicado 2013

The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors

por Redwood, Abena B., Zhang, Xiaomei, Seth, Sahil B., Ge, Zhongqi, Bindeman, Wendy E., Zhou, Xinhui, Sinha, Vidya C., Heffernan, Timothy P., Piwnica-Worms, Helen
Publicado 2021

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

por Lee, Michael S., Helms, Timothy L., Feng, Ningping, Gay, Jason, Chang, Qing Edward, Tian, Feng, Wu, Ji Y., Toniatti, Carlo, Heffernan, Timothy P., Powis, Garth, Kwong, Lawrence N., Kopetz, Scott
Publicado 2016

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

por Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda
Publicado 2008

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

por Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.
Publicado 2018

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

por Echeverria, Gloria V., Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L., Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L., Symmans, William F., Chang, Jeffrey T., Heffernan, Timothy P., Piwnica-Worms, Helen
Publicado 2018

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

por Zhan, Yanai, Kost-Alimova, Maria, Shi, Xi, Leo, Elisabetta, Bardenhagen, Jennifer P., Shepard, Hannah E., Appikonda, Srikanth, Vangamudi, Bhavatarini, Zhao, Shuping, Tieu, Trang N., Jiang, Shiming, Heffernan, Timothy P., Marszalek, Joseph R., Toniatti, Carlo, Draetta, Giulio, Tyler, Jessica, Barton, Michelle, Jones, Philip, Palmer, Wylie S., Geck Do, Mary K., Andersen, Jannik N.
Publicado 2015

A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

por Powell, Emily, Shao, Jiansu, Picon, Hector M., Bristow, Christopher, Ge, Zhongqi, Peoples, Michael, Robinson, Frederick, Jeter-Jones, Sabrina L., Schlosberg, Christopher, Grzeskowiak, Caitlin L., Yang, Fei, Wu, Yun, Wistuba, Ignacio, Moulder, Stacy L., Symmans, William F., Scott, Kenneth L., Edwards, John R., Liang, Han, Heffernan, Timothy P., Piwnica-Worms, Helen
Publicado 2018

Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy

por Shapiro, Daniel D., Zacharias, Niki Millward, Tripathi, Durga N., Karki, Menuka, Bertocchio, Jean‐Philippe, Soeung, Melinda, He, Rong, Westerman, Mary E., Gao, Jianjun, Rao, Priya, Lam, Truong N. A., Jonasch, Eric, Perelli, Luigi, Cheng, Emily H., Carugo, Alessandro, Heffernan, Timothy P., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M., Karam, Jose A., Msaouel, Pavlos
Publicado 2023

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

por Powell, Reid T., Redwood, Abena, Liu, Xuan, Guo, Lei, Cai, Shirong, Zhou, Xinhui, Tu, Yizheng, Zhang, Xiaomei, Qi, Yuan, Jiang, Yan, Echeverria, Gloria, Feng, Ningping, Ma, XiaoYan, Giuliani, Virginia, Marszalek, Joseph R., Heffernan, Timothy P., Vellano, Christopher P., White, Jason B., Stephan, Clifford, Davies, Peter J., Moulder, Stacy, Symmans, W. Fraser, Chang, Jeffrey T., Piwnica-Worms, Helen
Publicado 2020

Combined KRAS(G12C) and SOS1 inhibition enhances and extends the anti-tumor response in KRAS(G12C)-driven cancers by addressing intrinsic and acquired resistance

por Thatikonda, Venu, Lu, Hengyu, Jurado, Sabine, Kostyrko, Kaja, Bristow, Christopher A., Bosch, Karin, Feng, Ningping, Gao, Sisi, Gerlach, Daniel, Gmachl, Michael, Lieb, Simone, Jeschko, Astrid, Machado, Annette A., Marszalek, Ethan D., Mahendra, Mikhila, Jaeger, Philipp A., Sorokin, Alexey, Strauss, Sandra, Trapani, Francesca, Kopetz, Scott, Vellano, Christopher P., Petronczki, Mark, Kraut, Norbert, Heffernan, Timothy P., Marszalek, Joseph R., Pearson, Mark, Waizenegger, Irene, Hofmann, Marco H.
Publicado 2023

SMARCB1 regulates the hypoxic stress response in sickle cell trait

por Soeung, Melinda, Perelli, Luigi, Chen, Ziheng, Dondossola, Eleonora, Ho, I-Lin, Carbone, Federica, Zhang, Li, Khan, Hania, Le, Courtney N., Zhu, Cihui, Peoples, Michael D., Feng, Ningping, Jiang, Shan, Zacharias, Niki Millward, Minelli, Rosalba, Shapiro, Daniel D., Deem, Angela K., Gao, Sisi, Cheng, Emily H., Lucchetti, Donatella, Walker, Cheryl L., Carugo, Alessandro, Giuliani, Virginia, Heffernan, Timothy P., Viale, Andrea, Tannir, Nizar M., Draetta, Giulio F., Msaouel, Pavlos, Genovese, Giannicola
Publicado 2023

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer

por Evans, Kurt W., Yuca, Erkan, Scott, Stephen S., Zhao, Ming, Paez Arango, Natalia, Cruz Pico, Christian X., Saridogan, Turcin, Shariati, Maryam, Class, Caleb A., Bristow, Christopher A., Vellano, Christopher P., Zheng, Xiaofeng, Gonzalez-Angulo, Ana Maria, Su, Xiaoping, Tapia, Coya, Chen, Ken, Akcakanat, Argun, Lim, Bora, Tripathy, Debu, Yap, Timothy A., Francesco, Maria Emilia Di, Draetta, Giulio F., Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R., Meric-Bernstam, Funda
Publicado 2021

Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

por Shapiro, Daniel D., Soeung, Melinda, Perelli, Luigi, Dondossola, Eleonora, Surasi, Devaki Shilpa, Tripathi, Durga N., Bertocchio, Jean-Philippe, Carbone, Federica, Starbuck, Michael W., Van Alstine, Michael L., Rao, Priya, Katz, Matthew H. G., Parker, Nathan H., Shah, Amishi Y., Carugo, Alessandro, Heffernan, Timothy P., Schadler, Keri L., Logothetis, Christopher, Walker, Cheryl L., Wood, Christopher G., Karam, Jose A., Draetta, Giulio F., Tannir, Nizar M., Genovese, Giannicola, Msaouel, Pavlos
Publicado 2021

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

por Punt, Simone, Malu, Shruti, McKenzie, Jodi A., Manrique, Soraya Zorro, Doorduijn, Elien M., Mbofung, Rina M., Williams, Leila, Silverman, Deborah A., Ashkin, Emily L., Dominguez, Ana Lucía, Wang, Zhe, Chen, Jie Qing, Maiti, Sourindra N., Tieu, Trang N., Liu, Chengwen, Xu, Chunyu, Forget, Marie-Andrée, Haymaker, Cara, Khalili, Jahan S., Satani, Nikunj, Muller, Florian, Cooper, Laurence J. N., Overwijk, Willem W., Amaria, Rodabe N., Bernatchez, Chantale, Heffernan, Timothy P., Peng, Weiyi, Roszik, Jason, Hwu, Patrick
Publicado 2020

Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma

por White, Michael G., Szczepaniak Sloane, Robert, Witt, Russell G., Reuben, Alexandre, Gaudreau, Pierre Olivier, Andrews, Miles C., Feng, Ningping, Johnson, Sarah, Class, Caleb A., Bristow, Christopher, Wani, Khalida, Hudgens, Courtney, Nezi, Luigi, Manzo, Teresa, De Macedo, Mariana Pettaccia, Hu, Jianhua, Davis, Richard, Jiang, Hong, Prieto, Peter, Burton, Elizabeth, Hwu, Patrick, Tawbi, Hussein, Gershenwald, Jeffrey, Lazar, Alexander J., Tetzlaff, Michael T., Overwijk, Willem, Woodman, Scott E, Cooper, Zachary A., Marszalek, Joseph R., Davies, Michael A., Heffernan, Timothy P., Wargo, Jennifer A.
Publicado 2021

Syndecan1 is a critical mediator of macropinocytosis in pancreatic cancer

por Yao, Wantong, Rose, Johnathon L., Wang, Wei, Seth, Sahil, Jiang, Hong, Taguchi, Ayumu, Liu, Jintan, Yan, Liang, Kapoor, Avnish, Hou, Pingping, Chen, Ziheng, Wang, Qiuyun, Nezi, Luigi, Xu, Zhaohui, Yao, Jun, Hu, Baoli, Pettazzoni, Piergiorgio F., Ho, I Lin, Feng, Ningping, Ramamoorthy, Vandhana, Jiang, Shan, Deng, Pingna, Ma, Grace J., Den, Peter, Tan, Zhi, Zhang, Shu Xing, Wang, Huamin, Wang, Alan Y., Deem, Angela K., Fleming, Jason B., Carugo, Alessandro, Heffernan, Timothy P., Maitra, Anirban, Viale, Andrea, Ying, Haoqiang, Hanash, Samir, DePinho, Ronald A., Draetta, Giulio F.
Publicado 2019

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

por Giuliani, Virginia, Miller, Meredith A., Liu, Chiu-Yi, Hartono, Stella R., Class, Caleb A., Bristow, Christopher A., Suzuki, Erika, Sanz, Lionel A., Gao, Guang, Gay, Jason P., Feng, Ningping, Rose, Johnathon L., Tomihara, Hideo, Daniele, Joseph R., Peoples, Michael D., Bardenhagen, Jennifer P., Geck Do, Mary K., Chang, Qing E., Vangamudi, Bhavatarini, Vellano, Christopher, Ying, Haoqiang, Deem, Angela K., Do, Kim-Anh, Genovese, Giannicola, Marszalek, Joseph R., Kovacs, Jeffrey J., Kim, Michael, Fleming, Jason B., Guccione, Ernesto, Viale, Andrea, Maitra, Anirban, Emilia Di Francesco, M., Yap, Timothy A., Jones, Philip, Draetta, Giulio, Carugo, Alessandro, Chedin, Frederic, Heffernan, Timothy P.
Publicado 2021