Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases

por Chiki, Anass, Ricci, Jonathan, Hegde, Ramanath, Abriata, Luciano A., Reif, Andreas, Boudeffa, Driss, Lashuel, Hilal A.
Publicado 2020

Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation

por Palmieri, Gianna, Bergamo, Paolo, Luini, Alberto, Ruvo, Menotti, Gogliettino, Marta, Langella, Emma, Saviano, Michele, Hegde, Ramanath N., Sandomenico, Annamaria, Rossi, Mose
Publicado 2011

A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

por Kumar, Senthil T., Mahul-Mellier, Anne-Laure, Hegde, Ramanath Narayana, Rivière, Gwladys, Moons, Rani, Ibáñez de Opakua, Alain, Magalhães, Pedro, Rostami, Iman, Donzelli, Sonia, Sobott, Frank, Zweckstetter, Markus, Lashuel, Hilal A.
Publicado 2022

Unravelling druggable signalling networks that control F508del-CFTR proteostasis

por Hegde, Ramanath Narayana, Parashuraman, Seetharaman, Iorio, Francesco, Ciciriello, Fabiana, Capuani, Fabrizio, Carissimo, Annamaria, Carrella, Diego, Belcastro, Vincenzo, Subramanian, Advait, Bounti, Laura, Persico, Maria, Carlile, Graeme, Galietta, Luis, Thomas, David Y, Di Bernardo, Diego, Luini, Alberto
Publicado 2015

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

por Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh‐Bains, Malvindar K, Dragunow, Mike, Curtis, Maurice A, Faull, Richard LM, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A
Publicado 2020

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

por Lashuel, Hilal A., Mahul-Mellier, Anne-Laure, Novello, Salvatore, Hegde, Ramanath Narayana, Jasiqi, Yllza, Altay, Melek Firat, Donzelli, Sonia, DeGuire, Sean M., Burai, Ritwik, Magalhães, Pedro, Chiki, Anass, Ricci, Jonathan, Boussouf, Manel, Sadek, Ahmed, Stoops, Erik, Iseli, Christian, Guex, Nicolas
Publicado 2022

Identification of p38 MAPK and JNK as new targets for correction of Wilson disease‐causing ATP7B mutants

por Chesi, Giancarlo, Hegde, Ramanath N., Iacobacci, Simona, Concilli, Mafalda, Parashuraman, Seetharaman, Festa, Beatrice Paola, Polishchuk, Elena V., Di Tullio, Giuseppe, Carissimo, Annamaria, Montefusco, Sandro, Canetti, Diana, Monti, Maria, Amoresano, Angela, Pucci, Piero, van de Sluis, Bart, Lutsenko, Svetlana, Luini, Alberto, Polishchuk, Roman S.
Publicado 2016