Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

por Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
Publicado 2014

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

por Commisso, Cosimo, Davidson, Shawn M., Soydaner-Azeloglu, Rengin G., Parker, Seth J., Kamphorst, Jurre J., Hackett, Sean, Grabocka, Elda, Nofal, Michel, Drebin, Jeffrey A., Thompson, Craig B., Rabinowitz, Joshua D., Metallo, Christian M., Heiden, Matthew G. Vander, Bar-Sagi, Dafna
Publicado 2013

SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

por Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
Publicado 2015

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

por McKenney, Anna Sophia, Lau, Allison N., Somasundara, Amritha Varshini Hanasoge, Spitzer, Barbara, Intlekofer, Andrew M., Ahn, Jihae, Shank, Kaitlyn, Rapaport, Franck T., Patel, Minal A., Papalexi, Efthymia, Shih, Alan H., Chiu, April, Freinkman, Elizaveta, Akbay, Esra A., Steadman, Mya, Nagaraja, Raj, Yen, Katharine, Teruya-Feldstein, Julie, Wong, Kwok-Kin, Rampal, Raajit, Heiden, Matthew G. Vander, Thompson, Craig B., Levine, Ross L.
Publicado 2018

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

por Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Leal, Lucía, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Ørntoft, Torben F., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Heiden, Matthew G. Vander, Albar, Juan Pablo, Esteller, Manel
Publicado 2014

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

por Abbott, Keene L., Ali, Ahmed, Casalena, Dominick, Do, Brian T., Ferreira, Raphael, Cheah, Jaime H., Soule, Christian K., Deik, Amy, Kunchok, Tenzin, Schmidt, Daniel R., Renner, Steffen, Honeder, Sophie E., Wu, Michelle, Chan, Sze Ham, Tseyang, Tenzin, Greaves, Daniel, Hsu, Peggy P., Ng, Christopher W., Zhang, Chelsea J., Farsidjani, Ali, Gramatikov, Iva Monique T., Matheson, Nicholas J., Lewis, Caroline A., Clish, Clary B., Rees, Matthew G., Roth, Jennifer A., Griner, Lesley Mathews, Muir, Alexander, Auld, Douglas S., Heiden, Matthew G. Vander
Publicado 2023

Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

por Mayers, Jared R., Wu, Chen, Clish, Clary B., Kraft, Peter, Torrence, Margaret E., Fiske, Brian P., Yuan, Chen, Bao, Ying, Townsend, Mary K., Tworoger, Shelley S., Davidson, Shawn M., Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L., Ogino, Shuji, Stampfer, Meir J., Giovannucci, Edward L., Qian, Zhi Rong, Rubinson, Douglas A., Ma, Jing, Sesso, Howard D., Gaziano, John Michael, Cochrane, Barbara B., Liu, Simin, Wactawski–Wende, Jean, Manson, JoAnn E., Pollak, Michael N., Kimmelman, Alec C., Souza, Amanda, Pierce, Kerry, Wang, Thomas J., Gerszten, Robert E., Fuchs, Charles S., Heiden, Matthew G. Vander, Wolpin, Brian M.
Publicado 2014