Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants

por Karinen, Sirkku, Heikkinen, Tuomas, Nevanlinna, Heli, Hautaniemi, Sampsa
Publicado 2011

MED12 mutations and fumarate hydratase inactivation in uterine adenomyomas

por Heikkinen, Tuomas, Äyräväinen, Anna, Hänninen, Janne, Ahvenainen, Terhi, Bützow, Ralf, Pasanen, Annukka, Vahteristo, Pia
Publicado 2018

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12

por Mäkinen, Netta, Aavikko, Mervi, Heikkinen, Tuomas, Taipale, Minna, Taipale, Jussi, Koivisto-Korander, Riitta, Bützow, Ralf, Vahteristo, Pia
Publicado 2016

Variants on the promoter region of PTEN affect breast cancer progression and patient survival

por Heikkinen, Tuomas, Greco, Dario, Pelttari, Liisa M, Tommiska, Johanna, Vahteristo, Pia, Heikkilä, Päivi, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli
Publicado 2011

3′RNA Sequencing Accurately Classifies Formalin-Fixed Paraffin-Embedded Uterine Leiomyomas

por Mehine, Miika, Khamaiseh, Sara, Ahvenainen, Terhi, Heikkinen, Tuomas, Äyräväinen, Anna, Pakarinen, Päivi, Härkki, Päivi, Pasanen, Annukka, Bützow, Ralf, Vahteristo, Pia
Publicado 2020

Identification of genetic markers with synergistic survival effect in cancer

por Louhimo, Riku, Laakso, Marko, Heikkinen, Tuomas, Laitinen, Susanna, Manninen, Pekka, Rogojin, Vladimir, Miettinen, Minna, Blomqvist, Carl, Liu, Jianjun, Nevanlinna, Heli, Hautaniemi, Sampsa
Publicado 2013

MiR-34a Expression Has an Effect for Lower Risk of Metastasis and Associates with Expression Patterns Predicting Clinical Outcome in Breast Cancer

por Peurala, Hanna, Greco, Dario, Heikkinen, Tuomas, Kaur, Sippy, Bartkova, Jirina, Jamshidi, Maral, Aittomäki, Kristiina, Heikkilä, Päivi, Bartek, Jiri, Blomqvist, Carl, Bützow, Ralf, Nevanlinna, Heli
Publicado 2011

Recurrent moderate‐risk mutations in Finnish breast and ovarian cancer patients

por Nurmi, Anna, Muranen, Taru A., Pelttari, Liisa M., Kiiski, Johanna I., Heikkinen, Tuomas, Lehto, Sini, Kallioniemi, Anne, Schleutker, Johanna, Bützow, Ralf, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli
Publicado 2019

A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase

por Mehine, Miika, Ahvenainen, Terhi, Khamaiseh, Sara, Härkönen, Jouni, Reinikka, Siiri, Heikkinen, Tuomas, Äyräväinen, Anna, Pakarinen, Päivi, Härkki, Päivi, Pasanen, Annukka, Levonen, Anna-Liisa, Bützow, Ralf, Vahteristo, Pia
Publicado 2022

MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas

por Kämpjärvi, Kati, Mäkinen, Netta, Mehine, Miika, Välipakka, Salla, Uimari, Outi, Pitkänen, Esa, Heinonen, Hanna-Riikka, Heikkinen, Tuomas, Tolvanen, Jaana, Ahtikoski, Anne, Frizzell, Norma, Sarvilinna, Nanna, Sjöberg, Jari, Bützow, Ralf, Aaltonen, Lauri A, Vahteristo, Pia
Publicado 2016

Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility

por Low, Yen Ling, Li, Yuqing, Humphreys, Keith, Thalamuthu, Anbupalam, Li, Yi, Darabi, Hatef, Wedrén, Sara, Bonnard, Carine, Czene, Kamila, Iles, Mark M., Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Hall, Per, Liu, Edison T., Liu, Jianjun
Publicado 2010

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

por Kämpjärvi, Kati, Järvinen, Tiina M., Heikkinen, Tuomas, Ruppert, Amy S., Senter, Leigha, Hoag, Kevin W., Dufva, Olli, Kontro, Mika, Rassenti, Laura, Hertlein, Erin, Kipps, Thomas J., Porkka, Kimmo, Byrd, John C., de la Chapelle, Albert, Vahteristo, Pia
Publicado 2014

Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer

por Li, Yuqing, Li, Yi, Wedrén, Sara, Li, Guoliang, Charn, Tze Howe, Desai, Kartiki Vasant, Bonnard, Carine, Czene, Kamila, Humphreys, Keith, Darabi, Hatef, Einarsdóttir, Kristjana, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Chia, Kee Seng, Nevanlinna, Heli, Hall, Per, Liu, Edison T, Liu, Jianjun
Publicado 2011

Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families

por Arason, Adalgeir, Gunnarsson, Haukur, Johannesdottir, Gudrun, Jonasson, Kristjan, Bendahl, Pär-Ola, Gillanders, Elizabeth M, Agnarsson, Bjarni A, Jönsson, Göran, Pylkäs, Katri, Mustonen, Aki, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Melin, Beatrice, Johannsson, Oskar TH, Møller, Pål, Winqvist, Robert, Nevanlinna, Heli, Borg, Åke, Barkardottir, Rosa B
Publicado 2010

A genome-wide association scan on estrogen receptor-negative breast cancer

por Li, Jingmei, Humphreys, Keith, Darabi, Hatef, Rosin, Gustaf, Hannelius, Ulf, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Pharoah, Paul DP, Dunning, Alison M, Ahmed, Shahana, Hooning, Maartje J, Hollestelle, Antoinette, Oldenburg, Rogier A, Alfredsson, Lars, Palotie, Aarno, Peltonen-Palotie, Leena, Irwanto, Astrid, Low, Hui Qi, Teoh, Garrett HK, Thalamuthu, Anbupalam, Kere, Juha, D'Amato, Mauro, Easton, Douglas F, Nevanlinna, Heli, Liu, Jianjun, Czene, Kamila, Hall, Per
Publicado 2010

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases...

por Blows, Fiona M., Driver, Kristy E., Schmidt, Marjanka K., Broeks, Annegien, van Leeuwen, Flora E., Wesseling, Jelle, Cheang, Maggie C., Gelmon, Karen, Nielsen, Torsten O., Blomqvist, Carl, Heikkilä, Päivi, Heikkinen, Tuomas, Nevanlinna, Heli, Akslen, Lars A., Bégin, Louis R., Foulkes, William D., Couch, Fergus J., Wang, Xianshu, Cafourek, Vicky, Olson, Janet E., Baglietto, Laura, Giles, Graham G., Severi, Gianluca, McLean, Catriona A., Southey, Melissa C., Rakha, Emad, Green, Andrew R., Ellis, Ian O., Sherman, Mark E., Lissowska, Jolanta, Anderson, William F., Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Provenzano, Elena, Dawson, Sarah-Jane, Dunning, Alison M., Humphreys, Manjeet, Easton, Douglas F., García-Closas, Montserrat, Caldas, Carlos, Pharoah, Paul D., Huntsman, David
Publicado 2010

The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

por Fagerholm, Rainer, Schmidt, Marjanka K., Khan, Sofia, Rafiq, Sajjad, Tapper, William, Aittomäki, Kristiina, Greco, Dario, Heikkinen, Tuomas, Muranen, Taru A., Fasching, Peter A., Janni, Wolfgang, Weinshilboum, Richard, Loehberg, Christian R., Hopper, John L., Southey, Melissa C., Keeman, Renske, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Chenevix-Trench, Georgia, Investigators, kConFab, Lambrechts, Diether, Wildiers, Hans, Chang-Claude, Jenny, Seibold, Petra, Couch, Fergus J., Olson, Janet E., Andrulis, Irene L., Knight, Julia A., García-Closas, Montserrat, Figueroa, Jonine, Hooning, Maartje J., Jager, Agnes, Shah, Mitul, Perkins, Barbara J., Luben, Robert, Hamann, Ute, Kabisch, Maria, Czene, Kamila, Hall, Per, Easton, Douglas F., Pharoah, Paul D.P., Liu, Jianjun, Eccles, Diana, Blomqvist, Carl, Nevanlinna, Heli
Publicado 2015

Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

por Walker, Logan C, Fredericksen, Zachary S, Wang, Xianshu, Tarrell, Robert, Pankratz, Vernon S, Lindor, Noralane M, Beesley, Jonathan, Healey, Sue, Chen, Xiaoqing, Stoppa-Lyonnet, Dominique, Tirapo, Carole, Giraud, Sophie, Mazoyer, Sylvie, Muller, Danièle, Fricker, Jean-Pierre, Delnatte, Capucine, Schmutzler, Rita K, Wappenschmidt, Barbara, Engel, Christoph, Schönbuchner, Ines, Deissler, Helmut, Meindl, Alfons, Hogervorst, Frans B, Verheus, Martijn, Hooning, Maartje J, van den Ouweland, Ans MW, Nelen, Marcel R, Ausems, Margreet GEM, Aalfs, Cora M, van Asperen, Christi J, Devilee, Peter, Gerrits, Monique M, Waisfisz, Quinten, Szabo, Csilla I, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Harrington, Patricia, Evans, D Gareth, Lalloo, Fiona, Eeles, Ros, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Eccles, Diana, Ong, Kai-Ren, Cook, Jackie, Rebbeck, Tim, Nathanson, Katherine L, Domchek, Susan M, Singer, Christian F, Gschwantler-Kaulich, Daphne, Dressler, Anne-Catharina, Pfeiler, Georg, Godwin, Andrew K, Heikkinen, Tuomas, Nevanlinna, Heli, Agnarsson, Bjarni A, Caligo, Maria Adelaide, Olsson, Håkan, Kristoffersson, Ulf, Liljegren, Annelie, Arver, Brita, Karlsson, Per, Melin, Beatrice, Sinilnikova, Olga M, McGuffog, Lesley, Antoniou, Antonis C, Chenevix-Trench, Georgia, Spurdle, Amanda B, Couch, Fergus J
Publicado 2010

Exploring the link between MORF4L1 and risk of breast cancer

por Martrat, Griselda, Maxwell, Christopher A, Tominaga, Emiko, Porta-de-la-Riva, Montserrat, Bonifaci, Núria, Gómez-Baldó, Laia, Bogliolo, Massimo, Lázaro, Conxi, Blanco, Ignacio, Brunet, Joan, Aguilar, Helena, Fernández-Rodríguez, Juana, Seal, Sheila, Renwick, Anthony, Rahman, Nazneen, Kühl, Julia, Neveling, Kornelia, Schindler, Detlev, Ramírez, María J, Castellà, María, Hernández, Gonzalo, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Platte, Radka, Evans, D Gareth, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Ong, Kai-Ren, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Brewer, Carole, Morrison, Patrick J, Porteous, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Pasini, Barbara, Ottini, Laura, Putignano, Anna Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Healey, Sue, Spurdle, Amanda, Chen, Xiaoqing, Beesley, Jonathan, Rookus, Matti A, Verhoef, Senno, Tilanus-Linthorst, Madeleine A, Vreeswijk, Maaike P, Asperen, Christi J, Bodmer, Danielle, Ausems, Margreet GEM, van Os, Theo A, Blok, Marinus J, Meijers-Heijboer, Hanne EJ, Hogervorst, Frans BL, Goldgar, David E, Buys, Saundra, John, Esther M, Miron, Alexander, Southey, Melissa, Daly, Mary B, Harbst, Katja, Borg, Åke, Rantala, Johanna, Barbany-Bustinza, Gisela, Ehrencrona, Hans, Stenmark-Askmalm, Marie, Kaufman, Bella, Laitman, Yael, Milgrom, Roni, Friedman, Eitan, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Timothy R, Johannsson, Oskar Thor, Couch, Fergus J, Wang, Xianshu, Fredericksen, Zachary, Cuadras, Daniel, Moreno, Víctor, Pientka, Friederike K, Depping, Reinhard, Caldés, Trinidad, Osorio, Ana, Benítez, Javier, Bueren, Juan, Heikkinen, Tuomas, Nevanlinna, Heli, Hamann, Ute, Torres, Diana, Caligo, Maria Adelaide, Godwin, Andrew K, Imyanitov, Evgeny N, Janavicius, Ramunas, Sinilnikova, Olga M, Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Verny-Pierre, Carole, Castera, Laurent, de Pauw, Antoine, Bignon, Yves-Jean, Uhrhammer, Nancy, Peyrat, Jean-Philippe, Vennin, Philippe, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Mortemousque, Isabelle, McGuffog, Lesley, Chenevix-Trench, Georgia, Pereira-Smith, Olivia M, Antoniou, Antonis C, Cerón, Julián, Tominaga, Kaoru, Surrallés, Jordi, Pujana, Miguel Angel
Publicado 2011

Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

por Kirchhoff, Tomas, Gaudet, Mia M., Antoniou, Antonis C., McGuffog, Lesley, Humphreys, Manjeet K., Dunning, Alison M., Bojesen, Stig E., Nordestgaard, Børge G., Flyger, Henrik, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Dork, Thilo, Schürmann, Peter, Karstens, Johann H., Hillemanns, Peter, Couch, Fergus J., Olson, Janet, Vachon, Celine, Wang, Xianshu, Cox, Angela, Brock, Ian, Elliott, Graeme, Reed, Malcolm W.R., Burwinkel, Barbara, Meindl, Alfons, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Broeks, Annegien, Schmidt, Marjanka K., Van ‘t Veer, Laura J., Braaf, Linde M., Johnson, Nichola, Fletcher, Olivia, Gibson, Lorna, Peto, Julian, Turnbull, Clare, Seal, Sheila, Renwick, Anthony, Rahman, Nazneen, Wu, Pei-Ei, Yu, Jyh-Cherng, Hsiung, Chia-Ni, Shen, Chen-Yang, Southey, Melissa C., Hopper, John L., Hammet, Fleur, Van Dorpe, Thijs, Dieudonne, Anne-Sophie, Hatse, Sigrid, Lambrechts, Diether, Andrulis, Irene L., Bogdanova, Natalia, Antonenkova, Natalia, Rogov, Juri I., Prokofieva, Daria, Bermisheva, Marina, Khusnutdinova, Elza, van Asperen, Christi J., Tollenaar, Robert A.E.M., Hooning, Maartje J., Devilee, Peter, Margolin, Sara, Lindblom, Annika, Milne, Roger L., Arias, José Ignacio, Zamora, M. Pilar, Benítez, Javier, Severi, Gianluca, Baglietto, Laura, Giles, Graham G., kConFab, Group, AOCS Study, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Holland, Helene, Healey, Sue, Wang-Gohrke, Shan, Chang-Claude, Jenny, Mannermaa, Arto, Kosma, Veli-Matti, Kauppinen, Jaana, Kataja, Vesa, Agnarsson, Bjarni A., Caligo, Maria A., Godwin, Andrew K., Nevanlinna, Heli, Heikkinen, Tuomas, Fredericksen, Zachary, Lindor, Noralane, Nathanson, Katherine L., Domchek, Susan M., SWE-BRCA, Loman, Niklas, Karlsson, Per, Askmalm, Marie Stenmark, Melin, Beatrice, von Wachenfeldt, Anna, HEBON, Hogervorst, Frans B. L., Verheus, Martijn, Rookus, Matti A., Seynaeve, Caroline, Oldenburg, Rogier A., Ligtenberg, Marjolijn J., Ausems, Margreet G.E.M., Aalfs, Cora M., Gille, Hans J.P., Wijnen, Juul T., Gómez García, Encarna B., EMBRACE, Peock, Susan, Cook, Margaret, Oliver, Clare T., Frost, Debra, Luccarini, Craig, Pichert, Gabriella, Davidson, Rosemarie, Chu, Carol, Eccles, Diana, Ong, Kai-Ren, Cook, Jackie, Douglas, Fiona, Hodgson, Shirley, Evans, D. Gareth, Eeles, Rosalind, Gold, Bert, Pharoah, Paul D.P., Offit, Kenneth, Chenevix-Trench, Georgia, Easton, Douglas F.
Publicado 2012