Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor

por Bauer, Sebastian, George, Suzanne, von Mehren, Margaret, Heinrich, Michael C.
Publicado 2021

Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways

por Pantaleo, Maria A, Nannini, Margherita, Corless, Christopher L, Heinrich, Michael C
Publicado 2015

Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Registry

por Call, Jerry W., Wang, Yu, Montoya, Denisse, Scherzer, Norman J., Heinrich, Michael C.
Publicado 2019

Correction to: Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Regis...

por Call, Jerry W., Wang, Yu, Montoya, Denisse, Scherzer, Norman J., Heinrich, Michael C.
Publicado 2019

Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinica...

por von Mehren, Margaret, Heinrich, Michael C., Shi, Hongliang, Iannazzo, Sergio, Mankoski, Raymond, Dimitrijević, Saša, Hoehn, Gerard, Chiroli, Silvia, George, Suzanne
Publicado 2021

SDHC methylation in gastrointestinal stromal tumors (GIST): a case report

por Urbini, Milena, Astolfi, Annalisa, Indio, Valentina, Heinrich, Michael C., Corless, Christopher L., Nannini, Margherita, Ravegnini, Gloria, Biasco, Guido, Pantaleo, Maria A.
Publicado 2015

Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA

por Beadling, Carol, Patterson, Janice, Justusson, Emily, Nelson, Dylan, Pantaleo, Maria A., Hornick, Jason L., Chacón, Matias, Corless, Christopher L., Heinrich, Michael C.
Publicado 2013

Whole exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors

por Chmielecki, Juliann, Crago, Aimee M., Rosenberg, Mara, O'Connor, Rachael, Walker, Sarah R., Ambrogio, Lauren, Auclair, Daniel, McKenna, Aaron, Heinrich, Michael C., Frank, David A., Meyerson, Matthew
Publicado 2013

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

por Klug, Lillian R., Bannon, Amber E., Javidi-Sharifi, Nathalie, Town, Ajia, Fleming, William H., VanSlyke, Judy, Musil, Linda, Fletcher, Jonathan A., Tyner, Jeffrey W., Heinrich, Michael C.
Publicado 2018

Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers

por George, Suzanne, von Mehren, Margaret, Fletcher, Jonathan A., Sun, Jichao, Zhang, Sen, Pritchard, Justin R., Hodgson, John Graeme, Kerstein, David, Rivera, Victor M., Haluska, Frank G., Heinrich, Michael C.
Publicado 2022

A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor

por Pantaleo, Maria A., Heinrich, Michael C., Italiano, Antoine, Valverde, Claudia, Schöffski, Patrick, Grignani, Giovanni, Reyners, Anna K. L., Bauer, Sebastian, Reichardt, Peter, Stark, Daniel, Berhanu, Ghimja, Brandt, Ulrike, Stefanelli, Tommaso, Gelderblom, Hans
Publicado 2022

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)

por Nannini, Margherita, Astolfi, Annalisa, Urbini, Milena, Indio, Valentina, Santini, Donatella, Heinrich, Michael C, Corless, Christopher L, Ceccarelli, Claudio, Saponara, Maristella, Mandrioli, Anna, Lolli, Cristian, Ercolani, Giorgio, Brandi, Giovanni, Biasco, Guido, Pantaleo, Maria A
Publicado 2014

A Phase I, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Patients with Advanced Gastrointestinal Stromal Tumor

por George, Suzanne, Heinrich, Michael C., Somaiah, Neeta, Oppelt, Peter, McLeod, Robert, Nishioka, Satoshi, Kundu, Madan G., Qian, Xiaozhong, Kumar, Prasanna, Laadem, Abderrahmane, Lau, Yvonne, Tran, Brittany P., Fallon, Maura, Dosunmu, Ololade, Shi, Julia, Naito, Yoichi
Publicado 2023

Survey of Activated FLT3 Signaling in Leukemia

por Gu, Ting-lei, Nardone, Julie, Wang, Yi, Loriaux, Marc, Villén, Judit, Beausoleil, Sean, Tucker, Meghan, Kornhauser, Jon, Ren, Jianmin, MacNeill, Joan, Gygi, Steven P., Druker, Brian J., Heinrich, Michael C., Rush, John, Polakiewicz, Roberto D.
Publicado 2011

Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib

por Janku, Filip, Abdul Razak, Albiruni R., Chi, Ping, Heinrich, Michael C., von Mehren, Margaret, Jones, Robin L., Ganjoo, Kristen, Trent, Jonathan, Gelderblom, Hans, Somaiah, Neeta, Hu, Simin, Rosen, Oliver, Su, Ying, Ruiz-Soto, Rodrigo, Gordon, Michael, George, Suzanne
Publicado 2020

Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)

por Heinrich, Michael C., Patterson, Janice, Beadling, Carol, Wang, Yuexiang, Debiec-Rychter, Maria, Dewaele, Barbara, Corless, Christopher L., Duensing, Anette, Raut, Chandrajit P., Rubin, Brian, Ordog, Tamas, van de Rijn, Matt, Call, Jerry, Mühlenberg, Thomas, Fletcher, Jonathan A., Bauer, Sebastian
Publicado 2019

Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

por Ye, Shuai, Sharipova, Dinara, Kozinova, Marya, Klug, Lilli, D’Souza, Jimson, Belinsky, Martin G., Johnson, Katherine J., Einarson, Margret B., Devarajan, Karthik, Zhou, Yan, Litwin, Samuel, Heinrich, Michael C., DeMatteo, Ronald, von Mehren, Margaret, Duncan, James S., Rink, Lori
Publicado 2021

Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene

por Indio, Valentina, Astolfi, Annalisa, Tarantino, Giuseppe, Urbini, Milena, Patterson, Janice, Nannini, Margherita, Saponara, Maristella, Gatto, Lidia, Santini, Donatella, do Valle, Italo F., Castellani, Gastone, Remondini, Daniel, Fiorentino, Michelangelo, von Mehren, Margaret, Brandi, Giovanni, Biasco, Guido, Heinrich, Michael C., Pantaleo, Maria Abbondanza
Publicado 2018

Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study

por Bauer, Sebastian, Heinrich, Michael C., George, Suzanne, Zalcberg, John R., Serrano, César, Gelderblom, Hans, Jones, Robin L., Attia, Steven, D'Amato, Gina, Chi, Ping, Reichardt, Peter, Meade, Julie, Su, Ying, Ruiz-Soto, Rodrigo, Blay, Jean-Yves, von Mehren, Margaret, Schöffski, Patrick
Publicado 2021

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

por Reichardt, Peter, Demetri, George D., Gelderblom, Hans, Rutkowski, Piotr, Im, Seock-Ah, Gupta, Sudeep, Kang, Yoon-Koo, Schöffski, Patrick, Schuette, Jochen, Soulières, Denis, Blay, Jean-Yves, Goldstein, David, Fly, Kolette, Huang, Xin, Corsaro, Massimo, Lechuga, Maria Jose, Martini, Jean-Francois, Heinrich, Michael C.
Publicado 2016