mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic

por Van Lint, Sandra, Heirman, Carlo, Thielemans, Kris, Breckpot, Karine
Publicado 2013

Phase II study of autologous mRNA electroporated dendritic cells (TriMixDC-MEL) in combination with Ipilimumab in patients with pretreated advanced melanoma

por Thielemans, Kris, Neyns, Bart, Wilgenhof, Sofie, Corthals, Jurgen, Heirman, Carlo
Publicado 2014

Clinical trials with MRNA electroporated dendritic cells for stage III/IV melanoma patients

por Wilgenhof, Sofie, Corthals, Jurgen, Heirman, Carlo, Neyns, Bart, Thielemans, Kris
Publicado 2015

Characterization of CD8(+) T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMi...

por Benteyn, Daphné, Van Nuffel, An M. T., Wilgenhof, Sofie, Corthals, Jurgen, Heirman, Carlo, Neyns, Bart, Thielemans, Kris, Bonehill, Aude
Publicado 2013

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

por Van der Jeught, Kevin, Joe, Patrick Tjok, Bialkowski, Lukasz, Heirman, Carlo, Daszkiewicz, Lidia, Liechtenstein, Therese, Escors, David, Thielemans, Kris, Breckpot, Karine
Publicado 2014

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

por Joe, Patrick Tjok, Christopoulou, Ioanna, van Hoecke, Lien, Schepens, Bert, Ysenbaert, Tine, Heirman, Carlo, Thielemans, Kris, Saelens, Xavier, Aerts, Joeri L.
Publicado 2019

CD8α(+) and CD8α(−) Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

por Maldonado-López, Roberto, De Smedt, Thibaut, Michel, Patrick, Godfroid, Jacques, Pajak, Bernard, Heirman, Carlo, Thielemans, Kris, Leo, Oberdan, Urbain, Jacques, Moser, Muriel
Publicado 1999

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

por Broos, Katrijn, Van der Jeught, Kevin, Puttemans, Janik, Goyvaerts, Cleo, Heirman, Carlo, Dewitte, Heleen, Verbeke, Rein, Lentacker, Ine, Thielemans, Kris, Breckpot, Karine
Publicado 2016

Immunogenicity of targeted lentivectors

por Goyvaerts, Cleo, Kurt, De Groeve, Lint, Sandra Van, Heirman, Carlo, Van Ginderachter, Jo A., De Baetselier, Patrick, Raes, Geert, Thielemans, Kris, Breckpot, Karine
Publicado 2014

Targeting the tumor microenvironment to enhance antitumor immune responses

por Van der Jeught, Kevin, Bialkowski, Lukasz, Daszkiewicz, Lidia, Broos, Katrijn, Goyvaerts, Cleo, Renmans, Dries, Van Lint, Sandra, Heirman, Carlo, Thielemans, Kris, Breckpot, Karine
Publicado 2014

Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

por Bialkowski, Lukasz, van Weijnen, Alexia, Van der Jeught, Kevin, Renmans, Dries, Daszkiewicz, Lidia, Heirman, Carlo, Stangé, Geert, Breckpot, Karine, Aerts, Joeri L., Thielemans, Kris
Publicado 2016

Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

por Benteyn, Daphné, Anguille, Sébastien, Van Lint, Sandra, Heirman, Carlo, Van Nuffel, An MT, Corthals, Jurgen, Ochsenreither, Sebastian, Waelput, Wim, Van Beneden, Katrien, Breckpot, Karine, Van Tendeloo, Viggo, Thielemans, Kris, Bonehill, Aude
Publicado 2013

Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2

por Ren, Zhuo, Aerts, Joeri L, Vandenplas, Hugo, Wang, Jiance A, Gorbenko, Olena, Chen, Jack P, Giron, Philippe, Heirman, Carlo, Goyvaerts, Cleo, Zacksenhaus, Eldad, Minden, Mark D, Stambolic, Vuk, Breckpot, Karine, De Grève, Jacques
Publicado 2016

The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells

por Willemen, Yannick, Van den Bergh, Johan M.J., Bonte, Sarah M., Anguille, Sébastien, Heirman, Carlo, Stein, Barbara M.H., Goossens, Herman, Kerre, Tessa, Thielemans, Kris, Peeters, Marc, Van Tendeloo, Viggo F.I., Smits, Evelien L.J., Berneman, Zwi N.
Publicado 2016

GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma

por van Beek, Adriaan A., Zhou, Guoying, Doukas, Michail, Boor, Patrick P.C., Noordam, Lisanne, Mancham, Shanta, Campos Carrascosa, Lucia, van der Heide‐Mulder, Marieke, Polak, Wojciech G., Ijzermans, Jan N.M., Pan, Qiuwei, Heirman, Carlo, Mahne, Ashley, Bucktrout, Samantha L., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap
Publicado 2019

Phase I clinical trial of an intranodally administered mRNA-based therapeutic vaccine against HIV-1 infection

por Leal, Lorna, Guardo, Alberto C., Morón-López, Sara, Salgado, Maria, Mothe, Beatriz, Heirman, Carlo, Pannus, Pieter, Vanham, Guido, van den Ham, Henk Jan, Gruters, Rob, Andeweg, Arno, Van Meirvenne, Sonja, Pich, Judit, Arnaiz, Joan Albert, Gatell, Josep M., Brander, Christian, Thielemans, Kris, Martínez-Picado, Javier, Plana, Montserrat, García, Felipe
Publicado 2018