PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models

por Lesch, Stefanie, Nottebrock, Alessia, Rataj, Felicitas, Heise, Constanze, Endres, Stefan, Kobold, Sebastian
Publicado 2022

Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to seco-Duocarmycins Targeting the Thioredoxin System

por Felber, Jan G., Kitowski, Annabel, Zeisel, Lukas, Maier, Martin S., Heise, Constanze, Thorn-Seshold, Julia, Thorn-Seshold, Oliver
Publicado 2023

Pyrrole Hemithioindigo Antimitotics with Near‐Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single‐Cell Precision

por Sailer, Alexander, Meiring, Joyce C. M., Heise, Constanze, Pettersson, Linda N., Akhmanova, Anna, Thorn‐Seshold, Julia, Thorn‐Seshold, Oliver
Publicado 2021

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

por Rataj, Felicitas, Kraus, Fabian B. T., Chaloupka, Michael, Grassmann, Simon, Heise, Constanze, Cadilha, Bruno L., Duewell, Peter, Endres, Stefan, Kobold, Sebastian
Publicado 2018

Photoswitchable Epothilone‐Based Microtubule Stabilisers Allow GFP‐Imaging‐Compatible, Optical Control over the Microtubule Cytoskeleton

por Gao, Li, Meiring, Joyce C. M., Heise, Constanze, Rai, Ankit, Müller‐Deku, Adrian, Akhmanova, Anna, Thorn‐Seshold, Julia, Thorn‐Seshold, Oliver
Publicado 2022

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

por Wiedemann, Gabriela M, Aithal, Celina, Kraechan, Angelina, Heise, Constanze, Cadilha, Bruno L, Zhang, Jin, Duewell, Peter, Ballotti, Robert, Endres, Stefan, Bertolotto, Corine, Kobold, Sebastian
Publicado 2018

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy

por Rataj, Felicitas, Jacobi, Severin J., Stoiber, Stefan, Asang, Florian, Ogonek, Justyna, Tokarew, Nicholas, Cadilha, Bruno L., van Puijenbroek, Erwin, Heise, Constanze, Duewell, Peter, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Publicado 2018

[5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity

por Rushworth, James L., Thawani, Aditya R., Fajardo-Ruiz, Elena, Meiring, Joyce C. M., Heise, Constanze, White, Andrew J. P., Akhmanova, Anna, Brandt, Jochen R., Thorn-Seshold, Oliver, Fuchter, Matthew J.
Publicado 2022

Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

por Müller-Deku, Adrian, Meiring, Joyce C. M., Loy, Kristina, Kraus, Yvonne, Heise, Constanze, Bingham, Rebekkah, Jansen, Klara I., Qu, Xiaoyi, Bartolini, Francesca, Kapitein, Lukas C., Akhmanova, Anna, Ahlfeld, Julia, Trauner, Dirk, Thorn-Seshold, Oliver
Publicado 2020

In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M

por Gao, Li, Meiring, Joyce C. M., Varady, Adam, Ruider, Iris E., Heise, Constanze, Wranik, Maximilian, Velasco, Cecilia D., Taylor, Jennifer A., Terni, Beatrice, Weinert, Tobias, Standfuss, Jörg, Cabernard, Clemens C., Llobet, Artur, Steinmetz, Michel O., Bausch, Andreas R., Distel, Martin, Thorn-Seshold, Julia, Akhmanova, Anna, Thorn-Seshold, Oliver
Publicado 2022

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

por Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Dorman, Klara, Oner, Arman, Lorenzini, Theo, Obeck, Hannah, Vänttinen, Mira, Di Pilato, Mauro, Pruessmann, Jasper N., Stoiber, Stefan, Huynh, Duc, Märkl, Florian, Seifert, Matthias, Manske, Katrin, Suarez-Gosalvez, Javier, Zeng, Yi, Lesch, Stefanie, Karches, Clara H., Heise, Constanze, Gottschlich, Adrian, Thomas, Moritz, Marr, Carsten, Zhang, Jin, Pandey, Dharmendra, Feuchtinger, Tobias, Subklewe, Marion, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
Publicado 2021

T cells armed with the C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

por Lesch, Stefanie, Blumenberg, Viktoria, Stoiber, Stefan, Gottschlich, Adrian, Ogonek, Justyna, Cadilha, Bruno L., Dantes, Zahra, Rataj, Felicitas, Dorman, Klara, Lutz, Johannes, Karches, Clara H., Heise, Constanze, Kurzay, Mathias, Larimer, Benjamin M., Grassmann, Simon, Rapp, Moritz, Nottebrock, Alessia, Kruger, Stephan, Tokarew, Nicholas, Metzger, Philipp, Hoerth, Christine, Benmebarek, Mohamed-Reda, Dhoqina, Dario, Grünmeier, Ruth, Seifert, Matthias, Oener, Arman, Umut, Öykü, Joaquina, Sandy, Vimeux, Lene, Tran, Thi, Hank, Thomas, Baba, Taisuke, Huynh, Duc, Megens, Remco TA., Janssen, Klaus-Peter, Jastroch, Martin, Lamp, Daniel, Ruehland, Svenja, Di Pilato, Mauro, Pruessmann, Jasper N., Thomas, Moritz, Marr, Carsten, Ormanns, Steffen, Reischer, Anna, Hristov, Michael, Tartour, Eric, Donnadieu, Emmanuel, Rothenfusser, Simon, Duewell, Peter, König, Lars M., Schnurr, Max, Subklewe, Marion, Liss, Andrew S., Halama, Niels, Reichert, Maximilian, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
Publicado 2021