Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress

por Hekimi, Siegfried
Publicado 2013

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

por Yang, Wen, Hekimi, Siegfried
Publicado 2010

Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival

por Hekimi, Siegfried, Hughes, Bryan
Publicado 2011

Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations

por Wang, Ying, Hekimi, Siegfried
Publicado 2020

Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells

por Wang, Ying, Hekimi, Siegfried
Publicado 2021

The efficacy of coenzyme Q(10) treatment in alleviating the symptoms of primary coenzyme Q(10) deficiency: A systematic review

por Wang, Ying, Hekimi, Siegfried
Publicado 2022

The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains functional by metalation with cobalt

por Wang, Ying, Hekimi, Siegfried
Publicado 2022

Mclk1(+/- )mice are not resistant to the development of atherosclerosis

por Hughes, Bryan G, Hekimi, Siegfried
Publicado 2009

A Mild Impairment of Mitochondrial Electron Transport Has Sex-Specific Effects on Lifespan and Aging in Mice

por Hughes, Bryan G., Hekimi, Siegfried
Publicado 2011

The impact of mitochondrial oxidative stress on bile acid-like molecules in C. elegans provides a new perspective on human metabolic diseases

por Liu, Ju-Ling, Hekimi, Siegfried
Publicado 2013

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

por Van Raamsdonk, Jeremy M., Hekimi, Siegfried
Publicado 2009

Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!

por Hekimi, Siegfried, Wang, Ying, Noë, Alycia
Publicado 2016

A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options

por Wang, Ying, Gumus, Evren, Hekimi, Siegfried
Publicado 2022

The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1(+/−) mice

por Lapointe, Jérôme, Wang, Ying, Bigras, Eve, Hekimi, Siegfried
Publicado 2012

Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data

por Hughes, Bryan G., Harrison, Paul M., Hekimi, Siegfried
Publicado 2017

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

por Wang, Ying, Branicky, Robyn, Noë, Alycia, Hekimi, Siegfried
Publicado 2018

Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism

por Lapointe, Jérôme, G. Hughes, Bryan, Bigras, Eve, Hekimi, Siegfried
Publicado 2014

A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1

por Liu, Ju-Ling, Yee, Callista, Wang, Ying, Hekimi, Siegfried
Publicado 2017

Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates

por Liu, Ju-Ling, Desjardins, David, Branicky, Robyn, Agellon, Luis B., Hekimi, Siegfried
Publicado 2012

An Enhanced Immune Response of Mclk1 (+/−) Mutant Mice Is Associated with Partial Protection from Fibrosis, Cancer and the Development of Biomarkers of Aging

por Wang, Dantong, Wang, Ying, Argyriou, Catherine, Carrière, Audrey, Malo, Danielle, Hekimi, Siegfried
Publicado 2012