Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189

por Stepan, Antonia F., Tran, Tuan P., Helal, Christopher J., Brown, Maria S., Chang, Cheng, O’Connor, Rebecca E., De Vivo, Michael, Doran, Shawn D., Fisher, Ethan L., Jenkinson, Stephen, Karanian, David, Kormos, Bethany L., Sharma, Raman, Walker, Gregory S., Wright, Ann S., Yang, Edward X., Brodney, Michael A., Wager, Travis T., Verhoest, Patrick R., Obach, R. Scott
Publicado 2018

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

por Butler, Christopher R., Ogilvie, Kevin, Martinez-Alsina, Luis, Barreiro, Gabriela, Beck, Elizabeth M., Nolan, Charles E., Atchison, Kevin, Benvenuti, Eric, Buzon, Leanne, Doran, Shawn, Gonzales, Cathleen, Helal, Christopher J., Hou, Xinjun, Hsu, Mei-Hui, Johnson, Eric F., Lapham, Kimberly, Lanyon, Lorraine, Parris, Kevin, O’Neill, Brian T., Riddell, David, Robshaw, Ashley, Vajdos, Felix, Brodney, Michael A.
Publicado 2016