Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study

por Mühlemann, Barbara, Thibeault, Charlotte, Hillus, David, Helbig, Elisa T., Lippert, Lena J., Tober-Lau, Pinkus, Schwarz, Tatjana, Müller, Marcel A., Witzenrath, Martin, Suttorp, Norbert, Sander, Leif E., Drosten, Christian, Jones, Terry C., Corman, Victor M., Kurth, Florian
Publicado 2021

Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study

por Lingscheid, Tilman, Lippert, Lena J., Hillus, David, Kruis, Tassilo, Thibeault, Charlotte, Helbig, Elisa T., Tober-Lau, Pinkus, Pfäfflin, Frieder, Müller-Redetzky, Holger, Witzenrath, Martin, Zoller, Thomas, Uhrig, Alexander, Opitz, Bastian, Suttorp, Norbert, Kramer, Tobias S., Sander, Leif E., Stegemann, Miriam S., Kurth, Florian
Publicado 2022

Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial

por Kurth, Florian, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Barbone, Gianluca, Eckart, Marius A., Kluge, Martin, Puengel, Tobias, Demir, Münevver, Röhle, Robert, Keller, Theresa, Ruwwe-Glösenkamp, Christoph, Witzenrath, Martin, Suttorp, Norbert, von Kalle, Christof, Sander, Leif E., Jochum, Christoph, Tacke, Frank
Publicado 2023

Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-19

por Thibeault, Charlotte, Bardtke, Lara, Vanshylla, Kanika, di Cristanziano, Veronica, Eberhardt, Kirsten A., Stubbemann, Paula, Hillus, David, Tober-Lau, Pinkus, Mukherjee, Parnika, Münn, Friederike, Lippert, Lena J., Helbig, Elisa T., Lingscheid, Tilman, Steinbeis, Fridolin, Mittermaier, Mirja, Witzenrath, Martin, Zoller, Thomas, Klein, Florian, Sander, Leif E., Kurth, Florian
Publicado 2023

Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An obse...

por Steinbeis, Fridolin, Thibeault, Charlotte, Doellinger, Felix, Ring, Raphaela Maria, Mittermaier, Mirja, Ruwwe-Glösenkamp, Christoph, Alius, Florian, Knape, Philipp, Meyer, Hans-Jakob, Lippert, Lena Johanna, Helbig, Elisa Theresa, Grund, Daniel, Temmesfeld-Wollbrück, Bettina, Suttorp, Norbert, Sander, Leif Erik, Kurth, Florian, Penzkofer, Tobias, Witzenrath, Martin, Zoller, Thomas
Publicado 2022

A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study

por Wang, Ziyue, Cryar, Adam, Lemke, Oliver, Tober-Lau, Pinkus, Ludwig, Daniela, Helbig, Elisa Theresa, Hippenstiel, Stefan, Sander, Leif-Erik, Blake, Daniel, Lane, Catherine S., Sayers, Rebekah L., Mueller, Christoph, Zeiser, Johannes, Townsend, StJohn, Demichev, Vadim, Mülleder, Michael, Kurth, Florian, Sirka, Ernestas, Hartl, Johannes, Ralser, Markus
Publicado 2022

Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February–March 2021

por Tober-Lau, Pinkus, Schwarz, Tatjana, Hillus, David, Spieckermann, Jana, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Koch, Willi, Bergfeld, Leon, Niemeyer, Daniela, Mühlemann, Barbara, Conrad, Claudia, Kasper, Stefanie, Münn, Friederike, Kunitz, Frank, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Sander, Leif Erik, Kurth, Florian, Corman, Victor M.
Publicado 2021

Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

por Aramburu, Iker Valle, Hoving, Dennis, Vernardis, Spyros I., Tin, Martha C.F., Ioannou, Marianna, Temkin, Mia I., De Vasconcelos, Nathalia M., Demichev, Vadim, Helbig, Elisa Theresa, Lippert, Lena, Stahl, Klaus, White, Matthew, Radbruch, Helena, Ihlow, Jana, Horst, David, Chiesa, Scott T., Deanfield, John E., David, Sascha, Bode, Christian, Kurth, Florian, Ralser, Markus, Papayannopoulos, Venizelos
Publicado 2022

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

por Hillus, David, Schwarz, Tatjana, Tober-Lau, Pinkus, Vanshylla, Kanika, Hastor, Hana, Thibeault, Charlotte, Jentzsch, Stefanie, Helbig, Elisa T, Lippert, Lena J, Tscheak, Patricia, Schmidt, Marie Luisa, Riege, Johanna, Solarek, André, von Kalle, Christof, Dang-Heine, Chantip, Gruell, Henning, Kopankiewicz, Piotr, Suttorp, Norbert, Drosten, Christian, Bias, Harald, Seybold, Joachim, Klein, Florian, Kurth, Florian, Corman, Victor Max, Sander, Leif Erik
Publicado 2021

Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19...

por Steinbeis, Fridolin, Knape, Philipp, Mittermaier, Mirja, Helbig, Elisa Theresa, Tober-Lau, Pinkus, Thibeault, Charlotte, Lippert, Lena Johanna, Xiang, Weiwei, Müller-Plathe, Moritz, Steinbrecher, Sarah, Meyer, Hans-Jakob, Ring, Raphaela Maria, Ruwwe-Glösenkamp, Christoph, Alius, Florian, Li, Yaosi, Müller-Redetzky, Holger, Uhrig, Alexander, Lingscheid, Tilman, Grund, Daniel, Temmesfeld-Wollbrück, Bettina, Suttorp, Norbert, Sander, Leif Erik, Kurth, Florian, Witzenrath, Martin, Zoller, Thomas
Publicado 2022

Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

por Schwarz, Tatjana, Tober-Lau, Pinkus, Hillus, David, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Koch, Willi, Landgraf, Irmgard, Michel, Janine, Bergfeld, Leon, Niemeyer, Daniela, Mühlemann, Barbara, Conrad, Claudia, Dang-Heine, Chantip, Kasper, Stefanie, Münn, Friederike, Kappert, Kai, Nitsche, Andreas, Tauber, Rudolf, Schmidt, Sein, Kopankiewicz, Piotr, Bias, Harald, Seybold, Joachim, von Kalle, Christof, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Sander, Leif Erik, Corman, Victor M., Kurth, Florian
Publicado 2021

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observat...

por Thibeault, Charlotte, Mühlemann, Barbara, Helbig, Elisa T., Mittermaier, Mirja, Lingscheid, Tilman, Tober-Lau, Pinkus, Meyer-Arndt, Lil A., Meiners, Leonie, Stubbemann, Paula, Haenel, Sascha S., Bosquillon de Jarcy, Laure, Lippert, Lena, Pfeiffer, Moritz, Stegemann, Miriam S., Roehle, Robert, Wiebach, Janine, Hippenstiel, Stefan, Zoller, Thomas, Müller-Redetzky, Holger, Uhrig, Alexander, Balzer, Felix, von Kalle, Christof, Suttorp, Norbert, Jones, Terry C., Drosten, Christian, Witzenrath, Martin, Sander, Leif E., Corman, Victor M., Kurth, Florian
Publicado 2021

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

por Georg, Philipp, Astaburuaga-García, Rosario, Bonaguro, Lorenzo, Brumhard, Sophia, Michalick, Laura, Lippert, Lena J., Kostevc, Tomislav, Gäbel, Christiane, Schneider, Maria, Streitz, Mathias, Demichev, Vadim, Gemünd, Ioanna, Barone, Matthias, Tober-Lau, Pinkus, Helbig, Elisa T., Hillus, David, Petrov, Lev, Stein, Julia, Dey, Hannah-Philine, Paclik, Daniela, Iwert, Christina, Mülleder, Michael, Aulakh, Simran Kaur, Djudjaj, Sonja, Bülow, Roman D., Mei, Henrik E., Schulz, Axel R., Thiel, Andreas, Hippenstiel, Stefan, Saliba, Antoine-Emmanuel, Eils, Roland, Lehmann, Irina, Mall, Marcus A., Stricker, Sebastian, Röhmel, Jobst, Corman, Victor M., Beule, Dieter, Wyler, Emanuel, Landthaler, Markus, Obermayer, Benedikt, von Stillfried, Saskia, Boor, Peter, Demir, Münevver, Wesselmann, Hans, Suttorp, Norbert, Uhrig, Alexander, Müller-Redetzky, Holger, Nattermann, Jacob, Kuebler, Wolfgang M., Meisel, Christian, Ralser, Markus, Schultze, Joachim L., Aschenbrenner, Anna C., Thibeault, Charlotte, Kurth, Florian, Sander, Leif E., Blüthgen, Nils, Sawitzki, Birgit
Publicado 2022

A time-resolved proteomic and prognostic map of COVID-19

por Demichev, Vadim, Tober-Lau, Pinkus, Lemke, Oliver, Nazarenko, Tatiana, Thibeault, Charlotte, Whitwell, Harry, Röhl, Annika, Freiwald, Anja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Aulakh, Simran Kaur, Helbig, Elisa T., Stubbemann, Paula, Lippert, Lena J., Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Mittermaier, Mirja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Enghard, Philipp, Zelezniak, Aleksej, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Müller-Redetzky, Holger, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A., Tancevski, Ivan, Timms, John F., Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Ralser, Markus, Kurth, Florian
Publicado 2021

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

por Weiner, January, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H., Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arjun Arkal, Rao, Fragiadakis, Gabriela K., Mick, Eran, COMET, Consortium, Calfee, Carolyn S., Erle, David J., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Langelier, Charles R., Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, Heidecker, Bettina
Publicado 2021

A proteomic survival predictor for COVID-19 patients in intensive care

por Demichev, Vadim, Tober-Lau, Pinkus, Nazarenko, Tatiana, Lemke, Oliver, Kaur Aulakh, Simran, Whitwell, Harry J., Röhl, Annika, Freiwald, Anja, Mittermaier, Mirja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Lippert, Lena J., Helbig, Elisa T., Stubbemann, Paula, Olk, Nadine, Thibeault, Charlotte, Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Spies, Claudia, Edel, Andreas, Müller, Nils B., Enghard, Philipp, Zelezniak, Aleksej, Bellmann-Weiler, Rosa, Weiss, Günter, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A., Tancevski, Ivan, Timms, John F., Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Müller-Redetzky, Holger, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Kurth, Florian, Ralser, Markus
Publicado 2022

Detailed stratified GWAS analysis for severe COVID-19 in four European populations

por Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C, Arora, Jatin, Özer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Blandino Ortiz, Aaron, de Salazar, Adolfo, Garrido Chercoles, Adolfo, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Tanck, Anja, Hinney, Anke, Carreras Nolla, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Julià, Antonio, Muscatello, Antonio, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Schmidt, Axel, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Jensen, Björn, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, de la Horra, Carmen, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Spinner, Christoph D, Gassner, Christoph, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Prati, Daniele, Haschka, David, Jiménez, David, Pestaña, David, Toapanta, David, Muñiz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Helbig, Elisa T, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Calderón, Enrique J, Navas, Enrique, Solligård, Erik, Contro, Ernesto, Arana-Arri, Eunate, Aziz, Fátima, Garcia, Federico, García Sánchez, Félix, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Kurth, Florian, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J, Mesonero, Francisco, Rodriguez-Frias, Francisco, Hanses, Frank, Müller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Albano, Giovanni, Cardamone, Giulia, Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, My, Ilaria, Kurth, Ingo, Hernández, Isabel, Pink, Isabell, de Rojas, Itziar, Galván-Femenia, Iván, Holter, Jan Cato, Afset, Jan Egil, Heyckendorf, Jan, Kässens, Jan, Damås, Jan Kristian, Rybniker, Jan, Altmüller, Janine, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Banales, Jesus M, Badia, Joan Ramon, Dopazo, Joaquin, Schneider, Jochen, Bergan, Jonas, Barretina, Jordi, Walter, Jörn, Hernández Quero, Jose, Goikoetxea, Josune, Delgado, Juan, Guerrero, Juan M, Fazaal, Julia, Kraft, Julia, Schröder, Julia, Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I, Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Izquierdo-Sanchez, Laura, Bettini, Laura Rachele, Sumoy, Lauro, Sander, Leif Erik, Lippert, Lena J, Terranova, Leonardo, Nkambule, Lindokuhle, Knopp, Lisa, Gustad, Lise Tuset, Garbarino, Lucia, Santoro, Luigi, Téllez, Luis, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manolis, Riveiro-Barciela, Mar, Berger, Marc M, Schaefer, Marco, Niemi, Mari E K, Gutiérrez-Stampa, María A, Carrabba, Maria, Figuera Basso, Maria E, Valsecchi, Maria Grazia, Hernandez-Tejero, María, Vehreschild, Maria J G T, Manunta, Maria, Acosta-Herrera, Marialbert, D'Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M, Cornberg, Markus, Nöthen, Markus M, Marquié, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D'Amato, Mauro, Augustin, Max, Tomasi, Melissa, Boada, Mercè, Dreher, Michael, Seilmaier, Michael J, Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Miozzo, Monica, Imaz Ayo, Natale, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Marx, Nikolaus, Martínez, Nilda, Cornely, Oliver A, Witzke, Oliver, Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M, España, Pedro Pablo, Hoffmann, Per, Rosenstiel, Philip, Schommers, Philipp, Suwalski, Phillip, de Pablo, Raúl, Ferrer, Ricard, Bals, Robert, Gualtierotti, Roberta, Gallego-Durán, Rocío, Nieto, Rosa, Carpani, Rossana, Morilla, Rubén, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, May, Sandra, Bombace, Sara, Marsal, Sara, Pigazzini, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Bosari, Silvano, Volland, Sonja, Brunak, Søren, Raychaudhuri, Soumya, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Wesse, Tanja, Zheng, Tenghao, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola, Tomas, Feldt, Torsten, Folseraas, Trine, Gonzalez Cejudo, Trinidad, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Friaza, Vicente, Andrade, Victor, Moreno, Victor, Albrecht, Wolfgang, Peter, Wolfgang, Poller, Wolfgang, Farre, Xavier, Yi, Xiaoli, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, Latiano, Anna, Goerg, Siegfried, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Schulte, Eva C, Heidecker, Bettina, Ludwig, Kerstin U, Fernández, Javier, Romero-Gómez, Manuel, Albillos, Agustín, Invernizzi, Pietro, Buti, Maria, Duga, Stefano, Bujanda, Luis, Hov, Johannes R, Lenz, Tobias L, Asselta, Rosanna, de Cid, Rafael, Valenti, Luca, Karlsen, Tom H, Cáceres, Mario, Franke, Andre
Publicado 2022